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Bupropion and Depressions

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NeuroPsychopharmacotherapy

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Abstract

Bupropion is a norepinephrine and dopamine reuptake inhibitor. It is indicated for the treatment of major depressive disorder, for the prevention of major depressive episodes in patients with seasonal affective disorder, and for the treatment of nicotine addiction (Food and Drug Administration, FDA). Positive effects on fatigue and hypersomnia have been described. Compared to other antidepressants, it has a positive side effect profile especially concerning the risk of weight gain, sexual dysfunction, and QT prolongation. At higher doses, there is an increased risk of seizures. Due to its unique pharmacology, it might be used for pharmacological augmentation of serotonergic antidepressants.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle-Wittenberg, Halle/Saale, Germany

    Dan Rujescu, Stephan Röttig & Tim Johannes Krause

Authors
  1. Dan Rujescu
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  2. Stephan Röttig
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  3. Tim Johannes Krause
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Corresponding author

Correspondence to Dan Rujescu .

Editor information

Editors and Affiliations

  1. Dept Psychiatry , Psychosomatics & Psychotherapy, University of Würzburg, Medical School Clinical Neurochemistry, Würzburg, Germany

    Peter Riederer

  2. Inst für Psychologische Medizin, Haag, Bayern, Germany

    Gerd Laux

  3. Department of Psychiatry, University of Toronto Department of Psychiatry, Toronto, ON, Canada

    Benoit Mulsant

  4. Center Translational Res Neurol Diseases, Dalian Med Uni Shanghai Inst Health Sc Center Translational Res Neurol Diseases, Dalian, China

    Weidong Le

  5. Fujita Health University School Medicine, Toyoake, Aichi, Japan

    Toshiharu Nagatsu

Section Editor information

  1. Inst für Psychologische Medizin, Haag, Germany

    Gerd Laux

  2. Department of Psychiatry, Ludwig-Maximilians-University Munich, Munich, Germany

    Hans-Jürgen Möller

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Rujescu, D., Röttig, S., Krause, T.J. (2020). Bupropion and Depressions. In: Riederer, P., Laux, G., Mulsant, B., Le, W., Nagatsu, T. (eds) NeuroPsychopharmacotherapy. Springer, Cham. https://doi.org/10.1007/978-3-319-56015-1_83-1

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  • DOI: https://doi.org/10.1007/978-3-319-56015-1_83-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-56015-1

  • Online ISBN: 978-3-319-56015-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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