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Somnologics

Medicines for the Treatment of Sleep Disorders

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NeuroPsychopharmacotherapy

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Abstract

Sleep can be influenced and impaired in countless ways. Sleep disorders often severely impair quality of life and lead to high morbidity, as well as increased mortality. The indication for pharmacological treatment is based on the diagnosis of a sleep disorder, which often varies in symptoms, intensity, and duration. This chapter discusses medications for the treatment of sleep disorders and related symptoms. For more detailed information about sleep medicine diagnostics, as well as for nonpharmacological therapy modalities, please refer to the relevant sleep medical literature.

We herein propose a new classification and terminology for medicines for the treatment of sleep disorders: Somnologics (lat. somnologica). With a focus on insomnia disorders, trouble falling and staying asleep, we review substances that promote sleep (anti-insomnics), either by increasing sleep pressure (somnics) or by reducing wake pressure (antivigilantics). With regards to circadian rhythm disorders, we discuss substances for the realignment of the sleep phase (chronotherapeutics). After that, medications for the treatment of hypersomnia disorders, associated with an increased need for sleep, are reviewed (antihypersomnics). Herein, we include medications for the reduction of the sleep drive (vigilantics), as well as for the treatment of cataplexy (anticataplectics).

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References

  • Abad VC, Guilleminault C. Insomnia in elderly patients: recommendations for pharmacological management. Drugs Aging. 2018;35:791–817.

    Article  CAS  PubMed  Google Scholar 

  • Abdelgadir IS, Gordon MA, Akobeng AK. Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis. Arch Dis Child. 2018;103:1155–62.

    Article  PubMed  Google Scholar 

  • Abourashed EA, Koetter U, Brattstrom A. In vitro binding experiments with a Valerian, hops and their fixed combination extract (Ze91019) to selected central nervous system receptors. Phytomedicine. 2004;11:633–8.

    Article  CAS  PubMed  Google Scholar 

  • Adib-Hajbaghery M, Mousavi SN. The effects of chamomile extract on sleep quality among elderly people: a clinical trial. Complement Ther Med. 2017;35:109–14.

    Article  PubMed  Google Scholar 

  • Alshaikh MK, Tricco AC, Tashkandi M, Mamdani M, Straus SE, Bahammam AS. Sodium oxybate for narcolepsy with cataplexy: systematic review and meta-analysis. J Clin Sleep Med. 2012;8:451–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ancoli-Israel S, Krystal AD, Mccall WV, Schaefer K, Wilson A, Claus R, Rubens R, Roth T. A 12-week, randomized, double-blind, placebo-controlled study evaluating the effect of eszopiclone 2 mg on sleep/wake function in older adults with primary and comorbid insomnia. Sleep. 2010;33:225–34.

    Article  PubMed  PubMed Central  Google Scholar 

  • Anderson SL, Vande Griend JP. Quetiapine for insomnia: a review of the literature. Am J Health Syst Pharm. 2014;71:394–402.

    Article  CAS  PubMed  Google Scholar 

  • Apaydin EA, Maher AR, Shanman R, Booth MS, Miles JN, Sorbero ME, Hempel S. A systematic review of St. John’s wort for major depressive disorder. Syst Rev. 2016;5:148.

    Article  PubMed  PubMed Central  Google Scholar 

  • Atkin T, Comai S, Gobbi G. Drugs for insomnia beyond benzodiazepines: pharmacology, clinical applications, and discovery. Pharmacol Rev. 2018;70:197–245.

    Article  CAS  PubMed  Google Scholar 

  • Auld F, Maschauer EL, Morrison I, Skene DJ, Riha RL. Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. Sleep Med Rev. 2017;34:10–22.

    Article  PubMed  Google Scholar 

  • Babson KA, Sottile J, Morabito D. Cannabis, cannabinoids, and sleep: a review of the literature. Curr Psychiatry Rep. 2017;19:23.

    Article  PubMed  Google Scholar 

  • Barnes J, Anderson LA, Phillipson JD. St John’s wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. J Pharm Pharmacol. 2001;53:583–600.

    Article  CAS  PubMed  Google Scholar 

  • Barson JR. Orexin/hypocretin and dysregulated eating: promotion of foraging behavior. Brain Res. 2020;1731:145915.

    Article  CAS  PubMed  Google Scholar 

  • Barson JR, Leibowitz SF. Orexin/hypocretin system: role in food and drug overconsumption. Int Rev Neurobiol. 2017;136:199–237.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Beaubrun G, Gray GE. A review of herbal medicines for psychiatric disorders. Psychiatr Serv. 2000;51:1130–4.

    Article  CAS  PubMed  Google Scholar 

  • Bent S, Padula A, Moore D, Patterson M, Mehling W. Valerian for sleep: a systematic review and meta-analysis. Am J Med. 2006;119:1005–12.

    Article  PubMed  PubMed Central  Google Scholar 

  • Berry-Bibee EN, Kim MJ, Tepper NK, Riley HE, Curtis KM. Co-administration of St. John’s wort and hormonal contraceptives: a systematic review. Contraception. 2016;94:668–77.

    Article  CAS  PubMed  Google Scholar 

  • Birdsall TC. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev. 1998;3:271–80.

    CAS  PubMed  Google Scholar 

  • Bjerre LM, Farrell B, Hogel M, Graham L, Lemay G, Mccarthy L, Raman-Wilms L, Rojas-Fernandez C, Sinha S, Thompson W, Welch V, Wiens A. Deprescribing antipsychotics for behavioural and psychological symptoms of dementia and insomnia: evidence-based clinical practice guideline. Can Fam Physician. 2018;64:17–27.

    PubMed  PubMed Central  Google Scholar 

  • Boss C, Gatfield J, Brotschi C, Heidmann B, Sifferlen T, VON Raumer M, Schmidt G, Williams JT, Treiber A, Roch C. The quest for the best dual orexin receptor antagonist (daridorexant) for the treatment of insomnia disorders. ChemMedChem. 2020;15:2286–305.

    Article  CAS  PubMed  Google Scholar 

  • Brooks AT, Krumlauf M, Beck KH, Fryer CS, Yang L, Ramchandani VA, Wallen GR. A mixed methods examination of sleep throughout the alcohol recovery process grounded in the social cognitive theory: the role of self-efficacy and craving. Health Educ Behav. 2019;46:126–36.

    Article  PubMed  Google Scholar 

  • Buscemi N, Vandermeer B, Hooton N, Pandya R, Tjosvold L, Hartling L, Baker G, Klassen TP, Vohra S. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med. 2005;20:1151–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Buscemi N, Vandermeer B, Hooton N, Pandya R, Tjosvold L, Hartling L, Vohra S, Klassen TP, Baker G. Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis. BMJ. 2006;332:385–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Buth S, Holzbach R, Martens MS, Neumann-Runde E, Meiners O, Verthein U. Problematic medication with benzodiazepines, “Z-drugs”, and opioid analgesics. Dtsch Arztebl Int. 2019;116:607–14.

    PubMed  PubMed Central  Google Scholar 

  • Butterweck V, Brattstroem A, Grundmann O, Koetter U. Hypothermic effects of hops are antagonized with the competitive melatonin receptor antagonist luzindole in mice. J Pharm Pharmacol. 2007;59:549–52.

    Article  CAS  PubMed  Google Scholar 

  • Carter LP, Henningfield JE, Wang YG, Lu Y, Kelsh D, Vince B, Sellers E. A randomized, double-blind, placebo-controlled, crossover study to evaluate the human abuse liability of solriamfetol, a selective dopamine and norepinephrine reuptake inhibitor. J Psychopharmacol. 2018;32:1351–61.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chakravorty S, Chaudhary NS, Brower KJ. Alcohol dependence and its relationship with insomnia and other sleep disorders. Alcohol Clin Exp Res. 2016;40:2271–82.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chang SM, Chen CH. Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women: a randomized controlled trial. J Adv Nurs. 2016;72:306–15.

    Article  PubMed  Google Scholar 

  • Clinicaltrials.Gov. 2013–2015. Patient narcoleptic treated with BF2.649 (Pitolisant) in add-on to Sodium Oxybate (HARMONY IV) (HARMONY IV) [Online]. Available: https://clinicaltrials.gov/ct2/show/NCT01789398. Accessed 05/15 2021.

  • Cohrs S. Sleep disturbances in patients with schizophrenia: impact and effect of antipsychotics. CNS Drugs. 2008;22:939–62.

    Article  CAS  PubMed  Google Scholar 

  • Cranford JA, Arnedt JT, Conroy DA, Bohnert KM, Bourque C, Blow FC, Ilgen M. Prevalence and correlates of sleep-related problems in adults receiving medical cannabis for chronic pain. Drug Alcohol Depend. 2017;180:227–33.

    Article  PubMed  PubMed Central  Google Scholar 

  • Culpepper L, Wingertzahn MA. Over-the-counter agents for the treatment of occasional disturbed sleep or transient insomnia: a systematic review of efficacy and safety. Prim Care Companion CNS Disord. 2015:17.

    Google Scholar 

  • Dauvilliers Y, Bassetti C, Lammers GJ, Arnulf I, Mayer G, Rodenbeck A, Lehert P, Ding CL, Lecomte JM, Schwartz JC, GROUP, H. I. S. Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial. Lancet Neurol. 2013;12:1068–75.

    Article  CAS  PubMed  Google Scholar 

  • Dauvilliers Y, Arnulf I, Szakacs Z, Leu-Semenescu S, Lecomte I, Scart-Gres C, Lecomte JM, Schwartz JC, GROUP, H. I. S. Long-term use of pitolisant to treat patients with narcolepsy: harmony III Study. Sleep. 2019;42

    Google Scholar 

  • Dauvilliers Y, Zammit G, Fietze I, Mayleben D, Seboek Kinter D, Pain S, Hedner J. Daridorexant, a new dual orexin receptor antagonist to treat insomnia disorder. Ann Neurol. 2020;87:347–56.

    Article  CAS  PubMed  Google Scholar 

  • De Berardis D, Fornaro M, Serroni N, Campanella D, Rapini G, Olivieri L, Srinivasan V, Iasevoli F, Tomasetti C, De Bartolomeis A, Valchera A, Perna G, Mazza M, DI Nicola M, Martinotti G, Di Giannantonio M. Agomelatine beyond borders: current evidences of its efficacy in disorders other than major depression. Int J Mol Sci. 2015;16:1111–30.

    Article  PubMed  PubMed Central  Google Scholar 

  • Demisch L, Rother E. Neurobiologische Aspekte von L-Tryptophan, Serotonin und verwandten Indolaminen. In: Demisch L, editor. Therapie mit Präkursoren: Tryptophan, Serotonin und Indolderivate. Munich/Bern: W. Zuckschwerdt; 1987.

    Google Scholar 

  • Dhawan K, Dhawan S, Sharma A. Passiflora: a review update. J Ethnopharmacol. 2004;94:1–23.

    Article  CAS  PubMed  Google Scholar 

  • Dimpfel W, Brattstrom A, Koetter U. Central action of a fixed Valerian-hops extract combination (Ze 91019) in freely moving rats. Eur J Med Res. 2006;11:496–500.

    CAS  PubMed  Google Scholar 

  • Doering BK, Wegner A, Hadamitzky M, Engler H, Rief W, Schedlowski M. Effects of Neurexan (R) in an experimental acute stress setting – an explorative double-blind study in healthy volunteers. Life Sci. 2016;146:139–47.

    Article  CAS  PubMed  Google Scholar 

  • Donelli D, Antonelli M, Bellinazzi C, Gensini GF, Firenzuoli F. Effects of lavender on anxiety: a systematic review and meta-analysis. Phytomedicine. 2019;65:153099.

    Article  CAS  PubMed  Google Scholar 

  • Doremus JM, Stith SS, Vigil JM. Using recreational cannabis to treat insomnia: evidence from over-the-counter sleep aid sales in Colorado. Complement Ther Med. 2019;47:102207.

    Article  PubMed  Google Scholar 

  • Drake CL, Durrence H, Cheng P, Roth T, Pillai V, Peterson EL, Singh M, Tran KM. Arousability and fall risk during forced awakenings from nocturnal sleep among healthy males following administration of zolpidem 10 mg and doxepin 6 mg: a randomized, placebo-controlled, four-way crossover trial. Sleep. 2017;40

    Google Scholar 

  • Elam HB, Perez SM, Donegan JJ, Lodge DJ. Orexin receptor antagonists reverse aberrant dopamine neuron activity and related behaviors in a rodent model of stress-induced psychosis. Transl Psychiatry. 2021;11:114.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • EMEA - HMPC. Assessment report on Avena sativa L., herba and Avena sativa L., fructus. 2008a.

    Google Scholar 

  • EMEA - HMPC. Community herbal monograph on Avena sativa L., herba. 2008b.

    Google Scholar 

  • EMEA - HMPC. Community herbal monograph on Hypericum perforatum L., herba. 2009.

    Google Scholar 

  • EMEA - HMPC. Herbal medicine: summary for the public: Lavender oil, Lavandula angustifolia Mill., aetheroleum. 2013a.

    Google Scholar 

  • EMEA - HMPC. Herbal medicine: Summary for the public: Melissa leaf, Melissa officinalis L., folium. 2013b.

    Google Scholar 

  • EMEA - HMPC. Community herbal monograph on Passiflora incarnata L., herba. 2014.

    Google Scholar 

  • Ernst E, Rand JI, Barnes J, Stevinson C. Adverse effects profile of the herbal antidepressant St. John’s wort (Hypericum perforatum L.). Eur J Clin Pharmacol. 1998;54:589–94.

    Article  CAS  PubMed  Google Scholar 

  • Eshetie TC, Nguyen TA, Gillam MH, Kalisch Ellett LM. Potentially inappropriate prescribing in people with dementia: an Australian population-based study. Int J Geriatr Psychiatry. 2019;34:1498–505.

    Article  PubMed  Google Scholar 

  • Eugene AR. Association of sleep among 30 antidepressants: a population-wide adverse drug reaction study, 2004–2019. PeerJ. 2020;8:e8748.

    Article  PubMed  PubMed Central  Google Scholar 

  • Everitt H, Baldwin DS, Stuart B, Lipinska G, Mayers A, Malizia AL, Manson CC, Wilson S. Antidepressants for insomnia in adults. Cochrane Database Syst Rev. 2018;5:CD010753.

    PubMed  Google Scholar 

  • Fernandez-San-Martin MI, Masa-Font R, Palacios-Soler L, Sancho-Gomez P, Calbo-Caldentey C, Flores-Mateo G. Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials. Sleep Med. 2010;11:505–11.

    Article  PubMed  Google Scholar 

  • Ferracioli-Oda E, Qawasmi A, Bloch MH. Meta-analysis: melatonin for the treatment of primary sleep disorders. Focus (Am Psychiatr Publ). 2018;16:113–8.

    Google Scholar 

  • Figueiredo PR, Tolomeo S, Steele JD, Baldacchino A. Neurocognitive consequences of chronic cannabis use: a systematic review and meta-analysis. Neurosci Biobehav Rev. 2020;108:358–69.

    Article  PubMed  Google Scholar 

  • Foong AL, Patel T, Kellar J, Grindrod KA. The scoop on serotonin syndrome. Can Pharm J (Ott). 2018;151:233–9.

    Article  Google Scholar 

  • Ganz C. Arzneipflanze des Jahres 2017: Hafer (Avena sativa). Schweizerische Zeitschrift für Ganzheitsmedizin/Swiss J Integr Med. 2017;29:225–7.

    Article  Google Scholar 

  • Gauillard J, Cheref S, Vacherontrystram MN, Martin JC. Chloral hydrate: a hypnotic best forgotten? Encéphale. 2002;28:200–4.

    CAS  PubMed  Google Scholar 

  • Gianfredi V, Nucci D, Tonzani A, Amodeo R, Benvenuti AL, Villarini M, Moretti M. Sleep disorder, Mediterranean Diet and learning performance among nursing students: inSOMNIA, a cross-sectional study. Ann Ig. 2018;30:470–81.

    CAS  PubMed  Google Scholar 

  • Gobbi G, Atkin T, Zytynski T, Wang S, Askari S, Boruff J, Ware M, Marmorstein N, Cipriani A, Dendukuri N, Mayo N. Association of cannabis use in adolescence and risk of depression, anxiety, and suicidality in young adulthood: a systematic review and meta-analysis. JAMA Psychiatry. 2019;76:426–34.

    Article  PubMed  PubMed Central  Google Scholar 

  • Goodhines PA, Gellis LA, Kim J, Fucito LM, Park A. Self-medication for sleep in college students: concurrent and prospective associations with sleep and alcohol behavior. Behav Sleep Med. 2019;17:327–41.

    Article  PubMed  Google Scholar 

  • Greenberg MJ, Slyer JT. Effectiveness of Silexan oral lavender essential oil compared to inhaled lavender essential oil aromatherapy for sleep in adults: a systematic review. JBI Database System Rev Implement Rep. 2018;16:2109–17.

    Article  PubMed  Google Scholar 

  • Grigg-Damberger MM, Ianakieva D. Poor quality control of over-the-counter melatonin: what they say is often not what you get. J Clin Sleep Med. 2017;13:163–5.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hadley S, Petry JJ. Valerian. Am Fam Physician. 2003;67:1755–8.

    PubMed  Google Scholar 

  • Hajak G, Reimer A, Rüther E. Sleep-inducing effects of L-Tryptophan. In: Hans Steinhart WK, editor. L-tryptophan: current prospects in medicine and drug safety. Berlin: de Gruyter; 1994.

    Google Scholar 

  • Hajak G, Clarenbach P, Fischer W, Rodenbeck A, Bandelow B, Broocks A, Ruther E. Rebound insomnia after hypnotic withdrawal in insomniac outpatients. Eur Arch Psychiatry Clin Neurosci. 1998;248:148–56.

    Article  CAS  PubMed  Google Scholar 

  • Hajak G, Cluydts R, Declerck A, Estivill SE, Middleton A, Sonka K, Unden M. Continuous versus non-nightly use of zolpidem in chronic insomnia: results of a large-scale, double-blind, randomized, outpatient study. Int Clin Psychopharmacol. 2002;17:9–17.

    Article  CAS  PubMed  Google Scholar 

  • Hajak G, Cluydts R, Allain H, Estivill E, Parrino L, Terzano MG, Walsh JK. The challenge of chronic insomnia: is non-nightly hypnotic treatment a feasible alternative? Eur Psychiatry. 2003a;18:201–8.

    Article  CAS  PubMed  Google Scholar 

  • Hajak G, Muller WE, Wittchen HU, Pittrow D, Kirch W. Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data. Addiction. 2003b;98:1371–8.

    Article  CAS  PubMed  Google Scholar 

  • Hajak G, Lemme K, Zisapel N. Lasting treatment effects in a postmarketing surveillance study of prolonged-release melatonin. Int Clin Psychopharmacol. 2015;30:36–42.

    Article  PubMed  Google Scholar 

  • Hartmann E, Spinweber CL. Sleep induced by L-tryptophan. Effect of dosages within the normal dietary intake. J Nerv Ment Dis. 1979;167:497–9.

    Article  CAS  PubMed  Google Scholar 

  • Hauser W, Finnerup NB, Moore RA. Systematic reviews with meta-analysis on cannabis-based medicines for chronic pain: a methodological and political minefield. Pain. 2018;159:1906–7.

    Article  PubMed  Google Scholar 

  • Hauser W, Welsch P, Klose P, Radbruch L, Fitzcharles MA. Efficacy, tolerability and safety of cannabis-based medicines for cancer pain: a systematic review with meta-analysis of randomised controlled trials. Schmerz. 2019;33:424–36.

    Article  PubMed  Google Scholar 

  • Haybar H, Javid AZ, Haghighizadeh MH, Valizadeh E, Mohaghegh SM, Mohammadzadeh A. The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina. Clin Nutr ESPEN. 2018;26:47–52.

    Article  PubMed  Google Scholar 

  • Hellmann J, Drabek M, Yin J, Gunera J, Proll T, Kraus F, Langmead CJ, Hubner H, Weikert D, Kolb P, Rosenbaum DM, Gmeiner P. Structure-based development of a subtype-selective orexin 1 receptor antagonist. Proc Natl Acad Sci U S A. 2020;117:18059–67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Herring WJ, Snyder E, Budd K, Hutzelmann J, Snavely D, Liu K, Lines C, Roth T, Michelson D. Orexin receptor antagonism for treatment of insomnia: a randomized clinical trial of suvorexant. Neurology. 2012;79:2265–74.

    Article  CAS  PubMed  Google Scholar 

  • Herring WJ, Connor KM, Ivgy-May N, Snyder E, Liu K, Snavely DB, Krystal AD, Walsh JK, Benca RM, Rosenberg R, Sangal RB, Budd K, Hutzelmann J, Leibensperger H, Froman S, Lines C, Roth T, Michelson D. Suvorexant in patients with insomnia: results from two 3-month randomized controlled clinical trials. Biol Psychiatry. 2016;79:136–48.

    Article  CAS  PubMed  Google Scholar 

  • Herring WJ, Connor KM, Snyder E, Snavely DB, Morin CM, Lines C, Michelson D. Effects of suvorexant on the Insomnia Severity Index in patients with insomnia: analysis of pooled phase 3 data. Sleep Med. 2019a;56:219–23.

    Article  PubMed  Google Scholar 

  • Herring WJ, Roth T, Krystal AD, Michelson D. Orexin receptor antagonists for the treatment of insomnia and potential treatment of other neuropsychiatric indications. J Sleep Res. 2019b;28:e12782.

    Article  PubMed  Google Scholar 

  • Herring WJ, Ceesay P, Snyder E, Bliwise D, Budd K, Hutzelmann J, Stevens J, Lines C, Michelson D. Polysomnographic assessment of suvorexant in patients with probable Alzheimer’s disease dementia and insomnia: a randomized trial. Alzheimers Dement. 2020;16:541–51.

    Article  PubMed  PubMed Central  Google Scholar 

  • Herrmann L, Vicheva P, Kasties V, Danyeli LV, Szycik GR, Denzel D, Fan Y, Meer JV, Vester JC, Eskoetter H, Schultz M, Walter M. fMRI revealed reduced amygdala activation after Nx4 in mildly to moderately stressed healthy volunteers in a randomized, placebo-controlled, cross-over trial. Sci Rep. 2020;10:3802.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hieu TH, Dibas M, Surya Dila KA, Sherif NA, Hashmi MU, Mahmoud M, Trang NTT, Abdullah L, Nghia TLBYMN, Hirayama K, Huy NT. Therapeutic efficacy and safety of chamomile for state anxiety, generalized anxiety disorder, insomnia, and sleep quality: a systematic review and meta-analysis of randomized trials and quasi-randomized trials. Phytother Res. 2019;33:1604–15.

    Article  PubMed  Google Scholar 

  • Huether G, Hajak G, Reimer A, Poeggeler B, Blomer M, Rodenbeck A, Ruther E. The metabolic fate of infused L-tryptophan in men: possible clinical implications of the accumulation of circulating tryptophan and tryptophan metabolites. Psychopharmacology. 1992;109:422–32.

    Article  Google Scholar 

  • Huether G, Zhou D, Rüther E. Long-term modulation of presynaptic 5-HT-output: Experimentally induced changes in cortical 5-HT-transporter density, tryptophan hydroxylase content and 5-HT innervation density. J Neural Transm. 1997;104:993–1004.

    Article  CAS  PubMed  Google Scholar 

  • Janhsen K, Roser P, Hoffmann K. The problems of long-term treatment with benzodiazepines and related substances. Dtsch Arztebl Int. 2015;112:1–7.

    PubMed  PubMed Central  Google Scholar 

  • Ji MJ, Zhang XY, Chen Z, Wang JJ, Zhu JN. Orexin prevents depressive-like behavior by promoting stress resilience. Mol Psychiatry. 2019;24:282–93.

    Article  CAS  PubMed  Google Scholar 

  • Jiang B, He D, Gao Z. Efficacy and placebo response of multimodal treatments for primary insomnia: a network meta-analysis. Clin Neuropharmacol. 2019;42:197–202.

    Article  CAS  PubMed  Google Scholar 

  • Joya FL, Kripke DF, Loving RT, Dawson A, Kline LE. Meta-analyses of hypnotics and infections: eszopiclone, ramelteon, zaleplon, and zolpidem. J Clin Sleep Med. 2009;5:377–83.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kales HC, Lyketsos CG, Miller EM, Ballard C. Management of behavioral and psychological symptoms in people with Alzheimer’s disease: an international Delphi consensus. Int Psychogeriatr. 2019;31:83–90.

    Article  PubMed  Google Scholar 

  • Kasper S, Gastpar M, Muller WE, Volz HP, Moller HJ, Dienel A, Schlafke S. Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of ‘subsyndromal’ anxiety disorder: a randomized, double-blind, placebo controlled trial. Int Clin Psychopharmacol. 2010;25:277–87.

    Article  PubMed  Google Scholar 

  • Kasper S, Anghelescu I, Dienel A. Efficacy of orally administered Silexan in patients with anxiety-related restlessness and disturbed sleep – a randomized, placebo-controlled trial. Eur Neuropsychopharmacol. 2015;25:1960–7.

    Article  CAS  PubMed  Google Scholar 

  • Kato K, Hirai K, Nishiyama K, Uchikawa O, Fukatsu K, Ohkawa S, Kawamata Y, Hinuma S, Miyamoto M. Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist. Neuropharmacology. 2005;48:301–10.

    Article  CAS  PubMed  Google Scholar 

  • Kell G, Rao A, Beccaria G, Clayton P, Inarejos-Garcia AM, Prodanov M. affron((R)) a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial. Complement Ther Med. 2017;33:58–64.

    Article  PubMed  Google Scholar 

  • Khadivzadeh T, Abdolahian S, Ghazanfarpour M, Kargarfard L, Dizavandi FR, Khorsand I. A systematic review and meta-analysis on the effect of herbal medicine to manage sleep dysfunction in peri- and postmenopause. J Menopausal Med. 2018;24:92–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kim M, Lim HS, Lee HH, Kim TH. Role identification of Passiflora incarnata Linnaeus: a mini review. J Menopausal Med. 2017;23:156–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kim J, Lee SL, Kang I, Song YA, Ma J, Hong YS, Park S, Moon SI, Kim S, Jeong S, Kim JE. Natural products from single plants as sleep aids: a systematic review. J Med Food. 2018;21:433–44.

    Article  PubMed  Google Scholar 

  • Kim ME, Jun JH, Hur MH. Effects of aromatherapy on sleep quality: a systematic review and meta-analysis. J Korean Acad Nurs. 2019;49:655–76.

    Article  PubMed  Google Scholar 

  • Kolla BP, Mansukhani MP, Biernacka J, Chakravorty S, Karpyak VM. Sleep disturbances in early alcohol recovery: prevalence and associations with clinical characteristics and severity of alcohol consumption. Drug Alcohol Depend. 2020;206:107655.

    Article  PubMed  Google Scholar 

  • Korner E, Bertha G, Flooh E, Reinhart B, Wolf R, Lechner H. Sleep-inducing effect of L-tryptophane. Eur Neurol. 1986;25(Suppl 2):75–81.

    Article  PubMed  Google Scholar 

  • Krystal AD, Erman M, Zammit GK, Soubrane C, Roth T, GROUP, Z. S. Long-term efficacy and safety of zolpidem extended-release 12.5 mg, administered 3 to 7 nights per week for 24 weeks, in patients with chronic primary insomnia: a 6-month, randomized, double-blind, placebo-controlled, parallel-group, multicenter study. Sleep. 2008;31:79–90.

    Article  PubMed  PubMed Central  Google Scholar 

  • Krystal AD, Lankford A, Durrence HH, Ludington E, Jochelson P, Rogowski R, Roth T. Efficacy and safety of doxepin 3 and 6 mg in a 35-day sleep laboratory trial in adults with chronic primary insomnia. Sleep. 2011;34:1433–42.

    PubMed  PubMed Central  Google Scholar 

  • Krystal AD, Prather AA, Ashbrook LH. The assessment and management of insomnia: an update. World Psychiatry. 2019;18:337–52.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kurko T, Saastamoinen LK, Tuulio-Henriksson A, Taiminen T, Tiihonen J, Airaksinen M, Hietala J. Trends in the long-term use of benzodiazepine anxiolytics and hypnotics: a national register study for 2006 to 2014. Pharmacoepidemiol Drug Saf. 2018;27:674–82.

    Article  CAS  PubMed  Google Scholar 

  • Lahteenmaki R, Neuvonen PJ, Puustinen J, Vahlberg T, Partinen M, Raiha I, Kivela SL. Withdrawal from long-term use of zopiclone, zolpidem and temazepam may improve perceived sleep and quality of life in older adults with primary insomnia. Basic Clin Pharmacol Toxicol. 2019;124:330–40.

    Article  PubMed  Google Scholar 

  • Larzelere MM, Wiseman P. Anxiety, depression, and insomnia. Prim Care. 2002;29(339-60):vii.

    Google Scholar 

  • Leach MJ, Page AT. Herbal medicine for insomnia: a systematic review and meta-analysis. Sleep Med Rev. 2015;24:1–12.

    Article  PubMed  Google Scholar 

  • Lee J, Jung HY, Lee SI, Choi JH, Kim SG. Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study. Int Clin Psychopharmacol. 2020;35:29–35.

    Article  PubMed  Google Scholar 

  • Liang L, Huang Y, Xu R, Wei Y, Xiao L, Wang G. Eszopiclone for the treatment of primary insomnia: a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials. Sleep Med. 2019;62:6–13.

    Article  PubMed  Google Scholar 

  • Lieberman HR, Agarwal S, Fulgoni VL 3rd. Tryptophan intake in the US adult population is not related to liver or kidney function but is associated with depression and sleep outcomes. J Nutr. 2016;146:2609S–15S.

    Article  CAS  PubMed  Google Scholar 

  • Lin PC, Lee PH, Tseng SJ, Lin YM, Chen SR, Hou WH. Effects of aromatherapy on sleep quality: a systematic review and meta-analysis. Complement Ther Med. 2019;45:156–66.

    Article  PubMed  Google Scholar 

  • Linares IMP, Guimaraes FS, Eckeli A, Crippa ACS, Zuardi AW, Souza JDS, Hallak JE, Crippa JAS. No acute effects of cannabidiol on the sleep-wake cycle of healthy subjects: a randomized, double-blind, placebo-controlled, crossover study. Front Pharmacol. 2018;9:315.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lopresti AL, Smith SJ, Metse AP, Drummond PD. Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial. J Clin Sleep Med. 2020;16:937–47.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lovato N, Lack L. Insomnia and mortality: a meta-analysis. Sleep Med Rev. 2019;43:71–83.

    Article  PubMed  Google Scholar 

  • Lovell ME, Akhurst J, Padgett C, Garry MI, Matthews A. Cognitive outcomes associated with long-term, regular, recreational cannabis use in adults: a meta-analysis. Exp Clin Psychopharmacol. 2020;28:471–94.

    Article  PubMed  Google Scholar 

  • Malkani RG, Abbott SM, Reid KJ, Zee PC. Diagnostic and treatment challenges of sighted non-24-hour sleep-wake disorder. J Clin Sleep Med. 2018;14:603–13.

    Article  PubMed  PubMed Central  Google Scholar 

  • Marconi A, DI Forti M, Lewis CM, Murray RM, Vassos E. Meta-analysis of the association between the level of cannabis use and risk of psychosis. Schizophr Bull. 2016;42:1262–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Matussek N, Angst J, Benkert O, Gmur M, Papousek M, Ruther E, Woggon B. The effect of L-5-hydroxytryptophan alone and in combination with a decarboxylase inhibitor (Ro-4-4602) in depressive patients. Adv Biochem Psychopharmacol. 1974;11:399–404.

    CAS  PubMed  Google Scholar 

  • Mayer G, Plazzi G, Iranzo A, Ortega-Albas J, Quinnell T, Pesch H, Serralheiro P, Schlit AF, Wuiame D, Bentz JWG. Long-term compliance, safety, and tolerability of sodium oxybate treatment in patients with narcolepsy type 1: a postauthorization, noninterventional surveillance study. Sleep. 2018;41

    Google Scholar 

  • Mccleery J, Cohen DA, Sharpley AL. Pharmacotherapies for sleep disturbances in dementia. Cochrane Database Syst Rev. 2016;11:CD009178.

    PubMed  Google Scholar 

  • Melancon MO, Lorrain D, Dionne IJ. Exercise and sleep in aging: emphasis on serotonin. Pathol Biol (Paris). 2014;62:276–83.

    Article  CAS  Google Scholar 

  • Meolie AL, Rosen C, Kristo D, Kohrman M, Gooneratne N, Aguillard RN, Fayle R, Troell R, Townsend D, Claman D, Hoban T, Mahowald M, Clinical Practice Review, C. & American Academy of Sleep, M. Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence. J Clin Sleep Med. 2005;1:173–87.

    Article  PubMed  Google Scholar 

  • Michelson D, Snyder E, Paradis E, Chengan-Liu M, Snavely DB, Hutzelmann J, Walsh JK, Krystal AD, Benca RM, Cohn M, Lines C, Roth T, Herring WJ. Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2014;13:461–71.

    Article  CAS  PubMed  Google Scholar 

  • Milbank E, Lopez M. Orexins/hypocretins: key regulators of energy homeostasis. Front Endocrinol (Lausanne). 2019;10:830.

    Article  Google Scholar 

  • Minzenberg MJ, Carter CS. Developing treatments for impaired cognition in schizophrenia. Trends Cogn Sci. 2012;16:35–42.

    Article  PubMed  Google Scholar 

  • Moller HJ, Volz HP, Dienel A, Schlafke S, Kasper S. Efficacy of Silexan in subthreshold anxiety: meta-analysis of randomised, placebo-controlled trials. Eur Arch Psychiatry Clin Neurosci. 2019;269:183–93.

    Article  PubMed  Google Scholar 

  • Monti JM. The effect of second-generation antipsychotic drugs on sleep parameters in patients with unipolar or bipolar disorder. Sleep Med. 2016;23:89–96.

    Article  PubMed  Google Scholar 

  • Monti JM, Monti D. Sleep in schizophrenia patients and the effects of antipsychotic drugs. Sleep Med Rev. 2004;8:133–48.

    Article  PubMed  Google Scholar 

  • Monti JM, Torterolo P, Pandi Perumal SR. The effects of second generation antipsychotic drugs on sleep variables in healthy subjects and patients with schizophrenia. Sleep Med Rev. 2017;33:51–7.

    Article  PubMed  Google Scholar 

  • Morin CM, Koetter U, Bastien C, Ware JC, Wooten V. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep. 2005;28:1465–71.

    Article  PubMed  Google Scholar 

  • Morton WA, Stockton GG. Methylphenidate abuse and psychiatric side effects. Prim Care Companion J Clin Psychiatry. 2000;2:159–64.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mucke M, Phillips T, Radbruch L, Petzke F, Hauser W. Cannabis-based medicines for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2018;3:CD012182.

    PubMed  Google Scholar 

  • Muller CE, Schumacher B, Brattstrom A, Abourashed EA, Koetter U. Interactions of valerian extracts and a fixed valerian-hop extract combination with adenosine receptors. Life Sci. 2002;71:1939–49.

    Article  CAS  PubMed  Google Scholar 

  • Nasiri Lari Z, Hajimonfarednejad M, Riasatian M, Abolhassanzadeh Z, Iraji A, Vojoud M, Heydari M, Shams M. Efficacy of inhaled Lavandula angustifolia Mill. Essential oil on sleep quality, quality of life and metabolic control in patients with diabetes mellitus type II and insomnia. J Ethnopharmacol. 2020;251:112560.

    Article  CAS  PubMed  Google Scholar 

  • Neu P, Sofin Y, Danker-Hopfe H. The effect of detoxification on sleep: how does sleep quality change during qualified detoxification treatment? J Addict. 2018;2018:9492453.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ng QX, Venkatanarayanan N, Ho CY. Clinical use of Hypericum perforatum (St John's wort) in depression: a meta-analysis. J Affect Disord. 2017;210:211–21.

    Article  CAS  PubMed  Google Scholar 

  • Ngan A, Conduit R. A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality. Phytother Res. 2011;25:1153–9.

    Article  CAS  PubMed  Google Scholar 

  • Nicholson AN, Turner C, Stone BM, Robson PJ. Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. J Clin Psychopharmacol. 2004;24:305–13.

    Article  CAS  PubMed  Google Scholar 

  • Nishimon S, Nishimon M, Nishino S. Tasimelteon for treating non-24-h sleep-wake rhythm disorder. Expert Opin Pharmacother. 2019;20:1065–73.

    Article  CAS  PubMed  Google Scholar 

  • Nissen C, Frase L, Hajak G, Wetter TC. Hypnotics – state of the science. Nervenarzt. 2014;85:67–76.

    Article  CAS  PubMed  Google Scholar 

  • Nixon JP, Mavanji V, Butterick TA, Billington CJ, Kotz CM, Teske JA. Sleep disorders, obesity, and aging: the role of orexin. Ageing Res Rev. 2015;20:63–73.

    Article  CAS  PubMed  Google Scholar 

  • Perlis ML, Mccall WV, Krystal AD, Walsh JK. Long-term, non-nightly administration of zolpidem in the treatment of patients with primary insomnia. J Clin Psychiatry. 2004;65:1128–37.

    Article  CAS  PubMed  Google Scholar 

  • Perney P, Lehert P. Insomnia in alcohol-dependent patients: prevalence, risk factors and acamprosate effect: an individual patient data meta-analysis. Alcohol Alcohol. 2018;53:611–8.

    Article  CAS  PubMed  Google Scholar 

  • Pizzol D, Demurtas J, Stubbs B, Soysal P, Mason C, Isik AT, Solmi M, Smith L, Veronese N. Relationship between cannabis use and erectile dysfunction: a systematic review and meta-analysis. Am J Mens Health. 2019;13:1557988319892464.

    Article  PubMed  PubMed Central  Google Scholar 

  • Poly TN, Islam MM, Yang HC, Li, Y. J. Association between benzodiazepines use and risk of hip fracture in the elderly people: a meta-analysis of observational studies. Joint Bone Spine. 2020;87:241–9.

    Article  CAS  PubMed  Google Scholar 

  • Quintus C, Schweim HG. European regulation of herbal medicinal products on the border area to the food sector. Phytomedicine. 2012;19:378–81.

    Article  PubMed  Google Scholar 

  • Ranjbar M, Salehi A, Rezaeizadeh H, Zarshenas MM, Sadeghniiat-Haghighi K, Mirabzadeh M, Firoozabadi A. Efficacy of a combination of Melissa officinalis l. and Nepeta menthoides boiss. & Buhse on insomnia: a triple-blind, randomized placebo-controlled clinical trial. J Altern Complement Med. 2018;

    Google Scholar 

  • Riemann D, Baglioni C, Bassetti C, Bjorvatn B, Dolenc Groselj L, Ellis JG, Espie CA, Garcia-Borreguero D, Gjerstad M, Goncalves M, Hertenstein E, Jansson-Frojmark M, Jennum PJ, Leger D, Nissen C, Parrino L, Paunio T, Pevernagie D, Verbraecken J, Weess HG, Wichniak A, Zavalko I, Arnardottir ES, Deleanu OC, Strazisar B, Zoetmulder M, Spiegelhalder K. European guideline for the diagnosis and treatment of insomnia. J Sleep Res. 2017a;26:675–700.

    Article  PubMed  Google Scholar 

  • Riemann D, Baum E, Cohrs S, Crönlein T, Hajak G, Hertenstein E, Klose P, Langhorst J, Mayer G, Nissen C, Pollmächer T, Rabstein S, Schlarb A, Sitter H, Wees HG, Wetter T, Spiegelhalder K. S3-Leitlinie Nicht erholsamer Schlaf/Schlafstörungen. Somnologie. 2017b;21:2–44.

    Article  Google Scholar 

  • Riemann D, Baglioni C, Bassetti C, et al. European guideline for the diagnosis and treatment of insomnia. Guidelines. 2019;2019:12.

    Google Scholar 

  • Rivasi G, Kenny RA, Ungar A, Romero-Ortuno R. Effects of benzodiazepines on orthostatic blood pressure in older people. Eur J Int Med. 2020;72:73–8.

    Article  CAS  Google Scholar 

  • Rodenbeck A, Huether G, Ruther E, Hajak G. Altered circadian melatonin secretion patterns in relation to sleep in patients with chronic sleep-wake rhythm disorders. J Pineal Res. 1998;25:201–10.

    Article  CAS  PubMed  Google Scholar 

  • Roehrs T, Roth T. Insomnia as a path to alcoholism: tolerance development and dose escalation. Sleep. 2018;41

    Google Scholar 

  • Rosenberg R, Murphy P, Zammit G, Mayleben D, Kumar D, Dhadda S, Filippov G, Lopresti A, Moline M. Comparison of lemborexant with placebo and zolpidem tartrate extended release for the treatment of older adults with insomnia disorder: a phase 3 randomized clinical trial. JAMA Netw Open. 2019;2:e1918254.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rosner S, Englbrecht C, Wehrle R, Hajak G, Soyka M. Eszopiclone for insomnia. Cochrane Database Syst Rev. 2018;10:CD010703.

    PubMed  Google Scholar 

  • Rüther, E., Hüther, G. (Hrsg.) Das serotonerge System. UNI-MED Science. 2000. 1. Ed. ISBN 978-3-8374-4441-4.

    Google Scholar 

  • Sarris J, Byrne GJ. A systematic review of insomnia and complementary medicine. Sleep Med Rev. 2011;15:99–106.

    Article  PubMed  Google Scholar 

  • Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL. Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American academy of sleep medicine clinical practice guideline. J Clin Sleep Med. 2017;13:307–49.

    Article  PubMed  PubMed Central  Google Scholar 

  • Savage K, Firth J, Stough C, Sarris J. GABA-modulating phytomedicines for anxiety: a systematic review of preclinical and clinical evidence. Phytother Res. 2018;32:3–18.

    Article  CAS  PubMed  Google Scholar 

  • Sayed AM, Morsy S, Tawfik GM, Naveed S, Minh-Duc NT, Hieu TH, Ali ZA, Shinkar A, Doheim MF, Hashan MR, Huy NT. The best route of administration of lavender for anxiety: a systematic review and network meta-analysis. Gen Hosp Psychiatry. 2020;64:33–40.

    Article  PubMed  Google Scholar 

  • Schneider-Helmert D, Spinweber CL. Evaluation of L-tryptophan for treatment of insomnia: a review. Psychopharmacology. 1986;89:1–7.

    Article  CAS  PubMed  Google Scholar 

  • Schonmann Y, Goren O, Bareket R, Comaneshter D, Cohen AD, Vinker S. Chronic hypnotic use at 10 years-does the brand matter? Eur J Clin Pharmacol. 2018;74:1623–31.

    Article  CAS  PubMed  Google Scholar 

  • Schroeck JL, Ford J, Conway EL, Kurtzhalts KE, Gee ME, Vollmer KA, Mergenhagen KA. Review of safety and efficacy of sleep medicines in older adults. Clin Ther. 2016;38:2340–72.

    Article  CAS  PubMed  Google Scholar 

  • Schumacher B, Scholle S, Holzl J, Khudeir N, Hess S, Muller CE. Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors. J Nat Prod. 2002;65:1479–85.

    Article  CAS  PubMed  Google Scholar 

  • Schweizer CA, Hoggatt KJ, Washington DL, Bean-Mayberry B, Yano EM, Mitchell MN, Alessi CA, Martin JL. Use of alcohol as a sleep aid, unhealthy drinking behaviors, and sleeping pill use among women veterans. Sleep Health. 2019;5:495–500.

    Article  PubMed  PubMed Central  Google Scholar 

  • Seifritz E, Schlafke S, Holsboer-Trachsler E. Beneficial effects of Silexan on sleep are mediated by its anxiolytic effect. J Psychiatr Res. 2019;115:69–74.

    Article  PubMed  Google Scholar 

  • Setnik B, Sokolowska M, Johnson F, Oldenhof J, Romach M. Evaluation of the safety, pharmacodynamic, and pharmacokinetic effects following oral coadministration of immediate-release morphine with ethanol in healthy male participants. Hum Psychopharmacol. 2014;29:251–65.

    Article  CAS  PubMed  Google Scholar 

  • Sharpley AL, Mcgavin CL, Whale R, Cowen PJ. Antidepressant-like effect of Hypericum perforatum (St John’s wort) on the sleep polysomnogram. Psychopharmacology. 1998;139:286–7.

    Article  CAS  PubMed  Google Scholar 

  • Shinjyo N, Waddell G, Green J. Valerian root in treating sleep problems and associated disorders – a systematic review and meta-analysis. J Evid Based Integr Med. 2020;25:2515690X20967323.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sichardt K, Vissiennon Z, Koetter U, Brattstrom A, Nieber K. Modulation of postsynaptic potentials in rat cortical neurons by valerian extracts macerated with different alcohols: involvement of adenosine A(1)- and GABA(A)-receptors. Phytother Res. 2007;21:932–7.

    Article  CAS  PubMed  Google Scholar 

  • Snyder E, Ma J, Svetnik V, Connor KM, Lines C, Michelson D, Herring WJ. Effects of suvorexant on sleep architecture and power spectral profile in patients with insomnia: analysis of pooled phase 3 data. Sleep Med. 2016;19:93–100.

    Article  PubMed  Google Scholar 

  • Stockings E, Campbell G, Hall WD, Nielsen S, Zagic D, Rahman R, Murnion B, Farrell M, Weier M, Degenhardt L. Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies. Pain. 2018;159:1932–54.

    Article  CAS  PubMed  Google Scholar 

  • Subedi R, Singh R, Thakur RK, Bibek KC, Jha D, Ray BK. Efficacy and safety of solriamfetol for excessive daytime sleepiness in narcolepsy and obstructive sleep apnea: a systematic review and meta-analysis of clinical trials. Sleep Med. 2020;75:510–21.

    Article  PubMed  Google Scholar 

  • Sutanto CN, Loh WW, Kim JE. The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression. Nutr Rev. 2021;

    Google Scholar 

  • Swedish Council on Health Technology Assessment. Treatment of Insomnia in Adults: A Systematic Review [Internet]. Stockholm: Swedish Council on Health Technology Assessment (SBU); 2010 Jun. SBU Yellow Report No. 199. PMID: 28876752

    Google Scholar 

  • Sys J, Van Cleynenbreugel S, Deschodt M, Van der Linden L, Tournoy J. Efficacy and safety of non-benzodiazepine and non-Z-drug hypnotic medication for insomnia in older people: a systematic literature review. Eur J Clin Pharmacol. 2020;76:363–81.

    Article  CAS  PubMed  Google Scholar 

  • Szakacs Z, Dauvilliers Y, Mikhaylov V, Poverennova I, Krylov S, Jankovic S, Sonka K, Lehert P, Lecomte I, Lecomte JM, Schwartz JC, Group, H.-C. S. Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2017;16:200–7.

    Article  CAS  PubMed  Google Scholar 

  • Sznitman SR, Vulfsons S, Meiri D, Weinstein G. Medical cannabis and insomnia in older adults with chronic pain: a cross-sectional study. BMJ Support Palliat Care. 2020;10:415–20.

    Article  PubMed  Google Scholar 

  • Taavoni S, Nazem Ekbatani N, Haghani H. Valerian/lemon balm use for sleep disorders during menopause. Complement Ther Clin Pract. 2013;19:193–6.

    Article  CAS  PubMed  Google Scholar 

  • Taibi DM, Landis CA, Petry H, Vitiello MV. A systematic review of valerian as a sleep aid: safe but not effective. Sleep Med Rev. 2007;11:209–30.

    Article  PubMed  Google Scholar 

  • Thakkar MM, Engemann SC, Sharma R, Sahota P. Role of wake-promoting basal forebrain and adenosinergic mechanisms in sleep-promoting effects of ethanol. Alcohol Clin Exp Res. 2010;34:997–1005.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Thomas K, Canedo J, Perry PJ, Doroudgar S, Lopes I, Chuang HM, Bohnert K. Effects of valerian on subjective sedation, field sobriety testing and driving simulator performance. Accid Anal Prev. 2016;92:240–4.

    Article  PubMed  Google Scholar 

  • Thompson W, Quay TAW, Rojas-Fernandez C, Farrell B, Bjerre LM. Atypical antipsychotics for insomnia: a systematic review. Sleep Med. 2016;22:13–7.

    Article  PubMed  Google Scholar 

  • Tiwari S, Singh S, Tripathi S, Kumar S. A pharmacological review: Passiflora species. Int J Pharmacogn. 2016;3(1):10–8.

    CAS  Google Scholar 

  • Touchard J, Sabatier P, Airagnes G, Berdot S, Sabatier B. Consequences of the new zolpidem prescription regulations: a cohort study from the French national healthcare database. Eur J Clin Pharmacol. 2020;76:89–95.

    Article  CAS  PubMed  Google Scholar 

  • Umigai N, Takeda R, Mori A. Effect of crocetin on quality of sleep: a randomized, double-blind, placebo-controlled, crossover study. Complement Ther Med. 2018;41:47–51.

    Article  PubMed  Google Scholar 

  • United Nations International Drug Control Programme, U. N. O. F. D. C. A. C. P., and United Nations Office on Drugs and Crime 2019. World drug report. Oxford.

    Google Scholar 

  • Van Dalfsen JH, Markus CR. The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the sleep-promoting effects of tryptophan: a randomized placebo-controlled crossover study. J Psychopharmacol. 2019;33:948–54.

    Article  PubMed  PubMed Central  Google Scholar 

  • Vande Griend JP, Anderson SL. Histamine-1 receptor antagonism for treatment of insomnia. J Am Pharm Assoc. 2012;52:e210–9.

    Article  Google Scholar 

  • Velasco-Rodriguez R, Perez-Hernandez MG, Maturano-Melgoza JA, Hilerio-Lopez AG, Monroy-Rojas A, Arana-Gomez B, Vasquez C. The effect of aromatherapy with lavender (Lavandula angustifolia) on serum melatonin levels. Complement Ther Med. 2019;47:102208.

    Article  CAS  PubMed  Google Scholar 

  • Vissiennon Z, Sichardt K, Koetter U, Brattstrom A, Nieber K. Valerian extract Ze 911 inhibits postsynaptic potentials by activation of adenosine A1 receptors in rat cortical neurons. Planta Med. 2006;72:579–83.

    Article  CAS  PubMed  Google Scholar 

  • Waldschutz R, Klein P. The homeopathic preparation Neurexan vs. valerian for the treatment of insomnia: an observational study. ScientificWorldJournal. 2008;8:411–20.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang Y, Zou J, Jia Y, Liang Y, Zhang X, Wang CL, Wang X, Guo D, Shi Y, Yang M. A study on the mechanism of lavender in the treatment of insomnia based on network pharmacology. Comb Chem High Throughput Screen. 2020;23:419–32.

    Article  CAS  PubMed  Google Scholar 

  • Wang J, Li X, Yang S, Wang T, Xu Z, Xu J, Gao H, Chen G. Pitolisant versus placebo for excessive daytime sleepiness in narcolepsy and obstructive sleep apnea: a meta-analysis from randomized controlled trials. Pharmacol Res. 2021a;167:105522.

    Article  CAS  PubMed  Google Scholar 

  • Wang J, Yang S, Li X, Wang T, Xu Z, Xu X, Gao H, Chen G. Efficacy and safety of solriamfetol for excessive sleepiness in narcolepsy and obstructive sleep apnea: findings from randomized controlled trials. Sleep Med. 2021b;79:40–7.

    Article  PubMed  Google Scholar 

  • Wei S, Smits MG, Tang X, Kuang L, Meng H, Ni S, Xiao M, Zhou X. Efficacy and safety of melatonin for sleep onset insomnia in children and adolescents: a meta-analysis of randomized controlled trials. Sleep Med. 2020;68:1–8.

    Article  PubMed  Google Scholar 

  • Whiting PF, Wolff RF, Deshpande S, DI Nisio M, Duffy S, Hernandez AV, Keurentjes JC, Lang S, Misso K, Ryder S, Schmidlkofer S, Westwood M, Kleijnen J. Cannabinoids for medical use: a systematic review and meta-analysis. JAMA. 2015;313:2456–73.

    Article  CAS  PubMed  Google Scholar 

  • Wilt TJ, Macdonald R, Brasure M, Olson CM, Carlyle M, Fuchs E, Khawaja IS, Diem S, Koffel E, Ouellette J, Butler M, Kane RL. Pharmacologic treatment of insomnia disorder: an evidence report for a clinical practice guideline by the American College of Physicians. Ann Intern Med. 2016;165:103–12.

    Article  PubMed  Google Scholar 

  • Winkler A, Rief W. Effect of placebo conditions on polysomnographic parameters in primary insomnia: a meta-analysis. Sleep. 2015;38:925–31.

    PubMed  PubMed Central  Google Scholar 

  • Xing D, Ma XL, Ma JX, Wang J, Yang Y, Chen Y. Association between use of benzodiazepines and risk of fractures: a meta-analysis. Osteoporos Int. 2014;25:105–20.

    Article  CAS  PubMed  Google Scholar 

  • Yi XY, Ni SF, Ghadami MR, Meng HQ, Chen MY, Kuang L, Zhang YQ, Zhang L, Zhou XY. Trazodone for the treatment of insomnia: a meta-analysis of randomized placebo-controlled trials. Sleep Med. 2018;45:25–32.

    Article  PubMed  Google Scholar 

  • Yuan CS, Mehendale S, Xiao Y, Aung HH, Xie JT, Ang-Lee MK. The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. Anesth Analg. 2004;98:353–8.

    Article  CAS  PubMed  Google Scholar 

  • Yurcheshen M, Seehuus M, Pigeon W. Updates on nutraceutical sleep therapeutics and investigational research. Evid Based Complement Alternat Med. 2015;2015:105256.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhand N, Milin R. What do we know about the pharmacotheraputic management of insomnia in cannabis withdrawal: a systematic review. Am J Addict. 2018;27:453–64.

    Article  PubMed  Google Scholar 

  • Zick SM, Wright BD, Sen A, Arnedt JT. Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study. BMC Complement Altern Med. 2011;11:78.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ziegler G, Ploch M, Miettinen-Baumann A, Collet W. Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia – a randomized, double-blind, comparative clinical study. Eur J Med Res. 2002;7:480–6.

    CAS  PubMed  Google Scholar 

  • Zisapel N. New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. Br J Pharmacol. 2018;175:3190–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. ProSomno Clinic for Sleep Medicine, Munich, Germany

    Sebastian Herberger & Eckart Ruether

  2. Charité Interdisciplinary Centre of Sleep Medicine, Berlin, Germany

    Sebastian Herberger

  3. Clinic for Psychiatry and Psychotherapy, Bamberg, Germany

    Göran Hajak

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    Peter Riederer

  2. Inst für Psychologische Medizin, Haag, Bayern, Germany

    Gerd Laux

  3. Fujita Health University School Medicine, Toyoake, Aichi, Japan

    Toshiharu Nagatsu

  4. Center Translational Res Neurol Diseases, Dalian Med Uni Shanghai Inst Health Sc Center Translational Res Neurol Diseases, Dalian, China

    Weidong Le

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Herberger, S., Ruether, E., Hajak, G. (2021). Somnologics. In: Riederer, P., Laux, G., Nagatsu, T., Le, W., Riederer, C. (eds) NeuroPsychopharmacotherapy. Springer, Cham. https://doi.org/10.1007/978-3-319-56015-1_421-1

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  • DOI: https://doi.org/10.1007/978-3-319-56015-1_421-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-56015-1

  • Online ISBN: 978-3-319-56015-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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