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Imaging of Pediatric Central Nervous System Tumors

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Radiation Oncology for Pediatric CNS Tumors

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Abstract

Central nervous system (CNS) tumors are the most common type of solid tumors in the pediatric population. Neuroimaging is the sine quo non for state-of-the-art care of pediatric patients with central nervous system neoplasms. A variety of noninvasive imaging techniques are described which have shown utility in patient care from the time of initial diagnosis to surgical and radiation planning and then also during posttreatment surveillance for treatment effects, complications and to exclude recurrent disease. This overview of imaging techniques will hopefully give the reader a better understanding in choosing appropriate imaging strategies for optimal individualized patient care.

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References

  • Board PDQ PTE (2002) Childhood brain and spinal cord tumors treatment overview (PDQ(R)): health professional version. PDQ cancer information summaries. National Cancer Institute (US), Bethesda, MD

    Google Scholar 

  • Borja MJ, Plaza MJ, Altman N, Saigal G (2013) Conventional and advanced MRI features of pediatric intracranial tumors: supratentorial tumors. AJR Am J Roentgenol 200(5):W483–W503

    Article  PubMed  Google Scholar 

  • Carr JC, Shaibani A, Russell E, Finn JP (2001) Contrast-enhanced magnetic resonance angiography of the carotid circulation. Top Magn Reson Imaging 12(5):349–357

    Article  CAS  PubMed  Google Scholar 

  • Chen CC, Carter BS, Wang R et al (2016) Congress of neurological surgeons systematic review and evidence-based guideline on preoperative imaging assessment of patients with suspected nonfunctioning pituitary adenomas. Neurosurgery 79(4):E524–E526

    Article  PubMed  Google Scholar 

  • Chung EM, Specht CS, Schroeder JW (2007) From the archives of the AFIP: pediatric orbit tumors and tumorlike lesions: neuroepithelial lesions of the ocular globe and optic nerve. Radiographics 27(4):1159–1186

    Article  PubMed  Google Scholar 

  • Craig E, Connolly DJ, Griffiths PD, Raghavan A, Lee V, Batty R (2012) MRI protocols for imaging paediatric brain tumours. Clin Radiol 67(9):829–832

    Article  CAS  PubMed  Google Scholar 

  • Duffau H (2007) Contribution of cortical and subcortical electrostimulation in brain glioma surgery: methodological and functional considerations. Clin Neurophysiol 37(6):373–382

    Article  CAS  Google Scholar 

  • Fan X, Roberts DW, Schaewe TJ et al Intraoperative image updating for brain shift following dural opening. J Neurosurg 2016:1–10

    Google Scholar 

  • Fox PT, Mintun MA, Raichle ME, Herscovitch P (1984) A noninvasive approach to quantitative functional brain mapping with H2 (15)O and positron emission tomography. J Cereb Blood Flow Metab 4(3):329–333

    Article  CAS  PubMed  Google Scholar 

  • Garcia-Alvarez R, Liney GP, Beavis AW (2006) Repeatability of functional MRI for conformal avoidance radiotherapy planning. J Magn Reson Imaging 23(2):108–114

    Article  PubMed  Google Scholar 

  • Ho CY, Cardinal JS, Kamer AP, Lin C, Kralik SF (2016) Contrast leakage patterns from dynamic susceptibility contrast perfusion MRI in the grading of primary pediatric brain tumors. AJNR Am J Neuroradiol 37(3):544–551

    Article  CAS  PubMed  Google Scholar 

  • Hodler J, Kubik-Huch RA, von Schulthess GK (2016) Diseases of the brain, head and neck, spine 2016-2019: diagnostic imaging. Springer International Printing, Davos

    Book  Google Scholar 

  • Johnson J, Meader A, Hunt D (2012) Pearls and pitfalls of noninvasive carotid imaging. In: Abbara S, Kalva S (eds) Vascular imaging pearls and pitfalls. Springer, New York

    Google Scholar 

  • Jolesz FA (2005) Future perspectives for intraoperative MRI. Neurosurg Clin N Am 16(1):201–213

    Article  PubMed  Google Scholar 

  • Lam S, Lin Y, Warnke PC (2014) Permeability imaging in pediatric brain tumors. Transl Pediatr 3(3):218–228

    PubMed  PubMed Central  Google Scholar 

  • Law M, Yang S, Wang H et al (2003) Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging. AJNR Am J Neuroradiol 24(10):1989–1998

    PubMed  Google Scholar 

  • Le Bihan D, Iima M (2015) Diffusion magnetic resonance imaging: what water tells us about biological tissues. PLoS Biol 13(7):e1002203

    Article  PubMed  PubMed Central  Google Scholar 

  • Leclerc X, Gauvrit JY, Nicol L, Pruvo JP (1999) Contrast-enhanced MR angiography of the craniocervical vessels: a review. Neuroradiology 41(12):867–874

    Article  CAS  PubMed  Google Scholar 

  • Liu Y, Li F, Zhu S, Liu M, Wu C (2008) Clinical features and treatment of meningiomas in children: report of 12 cases and literature review. Pediatr Neurosurg 44(2):112–117

    Article  PubMed  Google Scholar 

  • Loeffler JS, Siddon RL, Wen PY, Nedzi LA, Alexander E III (1990) Stereotactic radiosurgery of the brain using a standard linear accelerator: a study of early and late effects. Radiother Oncol 17(4):311–321

    Article  CAS  PubMed  Google Scholar 

  • Mahesh M (2002) Search for isotropic resolution in CT from conventional through multiple-row detector. Radiographics 22(4):949–962

    Article  PubMed  Google Scholar 

  • Mangla R, Kolar B, Zhu T, Zhong J, Almast J, Ekholm S (2011) Percentage signal recovery derived from MR dynamic susceptibility contrast imaging is useful to differentiate common enhancing malignant lesions of the brain. AJNR Am J Neuroradiol 32(6):1004–1010

    Article  CAS  PubMed  Google Scholar 

  • Marx M, Langer T, Beck JD, Dorr HG (1999) Disorders of endocrine function after brain tumor therapy in childhood. Strahlenther Onkol 175(7):305–308

    Article  CAS  PubMed  Google Scholar 

  • Metcalfe P, Liney GP, Holloway L et al (2013) The potential for an enhanced role for MRI in radiation-therapy treatment planning. Technol Cancer Res Treat 12(5):429–446

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Muller J (2002) Disturbance of pubertal development after cancer treatment. Best Pract Res Clin Endocrinol Metab 16(1):91–103

    Article  PubMed  Google Scholar 

  • Mustert BR, Williams DM, Prince MR (1998) In vitro model of arterial stenosis: correlation of MR signal dephasing and trans-stenotic pressure gradients. Magn Reson Imaging 16(3):301–310

    Article  CAS  PubMed  Google Scholar 

  • Narayana A, Chang J, Thakur S et al (2007) Use of MR spectroscopy and functional imaging in the treatment planning of gliomas. Br J Radiol 80(953):347–354

    Article  CAS  PubMed  Google Scholar 

  • Nederkoorn PJ, van der Graaf Y, Eikelboom BC, van der Lugt A, Bartels LW, Mali WP (2002) Time-of-flight MR angiography of carotid artery stenosis: does a flow void represent severe stenosis? AJNR Am J Neuroradiol 23(10):1779–1784

    PubMed  Google Scholar 

  • Ogawa S, Tank DW, Menon R et al (1992) Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci U S A 89(13):5951–5955

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ostrom QT, Gittleman H, Liao P et al (2014) CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro Oncol 16(Suppl 4):iv1–i63

    Article  PubMed  PubMed Central  Google Scholar 

  • Ostrom QT, de Blank PM, Kruchko C et al (2015) Alex’s Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007-2011. Neuro Oncol 16(Suppl 10):x1–x36

    Article  PubMed  Google Scholar 

  • Paiva FF, Tannus A, Silva AC (2007) Measurement of cerebral perfusion territories using arterial spin labelling. NMR Biomed 20(7):633–642

    Article  PubMed  PubMed Central  Google Scholar 

  • Panigrahy A, Bluml S (2009) Neuroimaging of pediatric brain tumors: from basic to advanced magnetic resonance imaging (MRI). J Child Neurol 24(11):1343–1365

    Article  PubMed  Google Scholar 

  • Paulino AC, Simon JH, Zhen W, Wen BC (2000) Long-term effects in children treated with radiotherapy for head and neck rhabdomyosarcoma. Int J Radiat Oncol Biol Phys 48(5):1489–1495

    Article  CAS  PubMed  Google Scholar 

  • Pirotte BJ, Lubansu A, Massager N et al (2010) Clinical impact of integrating positron emission tomography during surgery in 85 children with brain tumors. J Neurosurg Pediatr 5(5):486–499

    Article  PubMed  Google Scholar 

  • Plathow C, Weber WA (2008) Tumor cell metabolism imaging. J Nucl Med 49(Suppl 2):43S–63S

    Article  CAS  PubMed  Google Scholar 

  • Plaza MJ, Borja MJ, Altman N, Saigal G (2013) Conventional and advanced MRI features of pediatric intracranial tumors: posterior fossa and suprasellar tumors. AJR Am J Roentgenol 200(5):1115–1124

    Article  PubMed  Google Scholar 

  • Pujol J, Conesa G, Deus J, Lopez-Obarrio L, Isamat F, Capdevila A (1998) Clinical application of functional magnetic resonance imaging in presurgical identification of the central sulcus. J Neurosurg 88(5):863–869

    Article  CAS  PubMed  Google Scholar 

  • Schmidt MA, Payne GS (2015) Radiotherapy planning using MRI. Phys Med Biol 60(22):R323–R361

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Verstappen CC, Heimans JJ, Hoekman K, Postma TJ (2003) Neurotoxic complications of chemotherapy in patients with cancer: clinical signs and optimal management. Drugs 63(15):1549–1563

    Article  CAS  PubMed  Google Scholar 

  • Vogl TJ, Balzer JO, Stemmler J, Bergman C, Egger E, Lissner J (1992) MR angiography in children with cerebral neurovascular diseases: findings in 31 cases. AJR Am J Roentgenol 159(4):817–823

    Article  CAS  PubMed  Google Scholar 

  • Wang HH, Luo CB, Guo WY et al (2013) Preoperative embolization of hypervascular pediatric brain tumors: evaluation of technical safety and outcome. Child’s Nerv Syst 29(11):2043–2049

    Article  Google Scholar 

  • Warren KE (2012) Diffuse intrinsic pontine glioma: poised for progress. Front Oncol 2:205

    Article  PubMed  PubMed Central  Google Scholar 

  • Weiss B (2008) Chemobrain: a translational challenge for neurotoxicology. Neurotoxicology 29(5):891–898

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang CW, Carr JC, Futterer SF et al (2005) Contrast-enhanced MR angiography of the carotid and vertebrobasilar circulations. AJNR Am J Neuroradiol 26(8):2095–2101

    PubMed  Google Scholar 

  • Yu J, Shi WE, Zhao R, Gao X, Li H (2015) Epidemiology of brain tumors in children aged two and under: a 10-year single-institute study. Oncol Lett 9(4):1651–1656

    PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Neurosurgery Department, Fundación Universitaria de Ciencias de la Salud, Hospital de San José, Hospital Infantil Universitario de San José, Bogotá D.C., Colombia

    Edgar G. Ordóñez-Rubiano M.D.

  2. Research Medical Library, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Rachel S. Hicklen M.L.S.

  3. School of Medicine, Universidad del Rosario, Bogotá D.C., Colombia

    Laura Rivera-Osorio M.D.

  4. Diagnostic Imaging, Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd. Unit 1482, Houston, TX, 77030, USA

    Jason M. Johnson M.D.

Authors
  1. Edgar G. Ordóñez-Rubiano M.D.
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  2. Rachel S. Hicklen M.L.S.
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  3. Laura Rivera-Osorio M.D.
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  4. Jason M. Johnson M.D.
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Corresponding author

Correspondence to Jason M. Johnson M.D. .

Editor information

Editors and Affiliations

  1. Dept. of Radiation Oncology, Mayo Clinic Dept. of Radiation Oncology, Rochester, Minnesota, USA

    Anita Mahajan

  2. MD Anderson Cancer Center, Houston, Texas, USA

    Arnold Paulino

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Ordóñez-Rubiano, E.G., Hicklen, R.S., Rivera-Osorio, L., Johnson, J.M. (2018). Imaging of Pediatric Central Nervous System Tumors. In: Mahajan, A., Paulino, A. (eds) Radiation Oncology for Pediatric CNS Tumors. Springer, Cham. https://doi.org/10.1007/978-3-319-55430-3_3

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  • DOI: https://doi.org/10.1007/978-3-319-55430-3_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-55428-0

  • Online ISBN: 978-3-319-55430-3

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