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Mitophagy in Starvation

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  • First Online:
Handbook of Famine, Starvation, and Nutrient Deprivation

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Abstract

Autophagy is a cellular degradation system and is drastically induced under starvation. In contrast to the ubiquitin–proteasome system, autophagy is a non-selective bulk degradation system. In the last decade, autophagy has been found to degrade cargo in a selective manner. Mitochondria can be degraded through mitochondria-specific autophagy, which is termed mitophagy, and several important factors have been identified in yeast and mammals. Atg32, a mitochondrial membrane protein, functions as a receptor during mitophagy under starvation in yeast. Post-translational modification of Atg32 induces mitochondrial degradation. In mammals, several different factors for mitophagy have been reported from different research groups. In this review, we summarize the molecular mechanisms of mitophagy in yeast and mammals with respect to Atg32 in yeast and its functional homolog in mammals.

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Abbreviations

AIM:

ATG8 interacting motif

ALS:

Amyotrophic lateral sclerosis

ATG:

Autophagy-related

BCL2L13:

Bcl2-like13

BNIP3:

BCL2/adenovirus E1B 19-kDa-interacting protein 3

BNIP3 like:

BNIP3L

CALCOCO2/NDP52:

Calcium binding and coiled-coil domain 2

CK2:

Casein kinase 2

Drp1:

Dynamin-related protein 1

ERK:

Extracellular signal-regulated kinase

FUNDC1:

FUN14 domain-containing protein 1

IMM:

Inner mitochondrial membrane

LIR:

LC3-interacting region

MAPK:

Mitogen-associated protein kinase

MEK:

MAPK/ERK kinase

MFF:

Mitochondrial fission factor

MFN:

Mitofusin

MiD:

Mitochondrial dynamics protein

MKK:

MAP kinase kinase

MLK:

Mixed-linage protein kinase

mtROS:

Mitochondrial ROS

NBR1:

Neighbor of BRCA1 gene 1

OMM:

Outer mitochondrial membrane

OPA1:

Optic atrophy 1

OPAG:

Primary open angle glaucoma

OPTN:

Optineurin

PAS:

Pre-autophagosomal structure

PI3K:

Phosphatidylinositol 3-kinase

PI3P:

Phosphatidylinositol 3-phosphate

PINK1:

PTEN-induced putative kinase 1

RAF:

Rapidly accelerated fibrosarcoma

ROS:

Reactive oxygen species

TAX1BP1:

TAX1 binding protein 1

TOR:

Target of rapamycin

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Authors and Affiliations

  1. Department of Cellular Physiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

    Shun-ichi Yamashita & Tomotake Kanki

Authors
  1. Shun-ichi Yamashita
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  2. Tomotake Kanki
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Correspondence to Tomotake Kanki .

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Editors and Affiliations

  1. Diabetes and Nutritional Sciences Research Division, Faculty of Life Science and Medicine, King’s College London, London, UK

    Victor R. Preedy

  2. School of Life Sciences, University of Westminster, London, UK

    Vinood B. Patel

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Yamashita, Si., Kanki, T. (2019). Mitophagy in Starvation. In: Preedy, V., Patel, V. (eds) Handbook of Famine, Starvation, and Nutrient Deprivation. Springer, Cham. https://doi.org/10.1007/978-3-319-55387-0_64

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  • DOI: https://doi.org/10.1007/978-3-319-55387-0_64

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