Skip to main content

Pharmacokinetic Drug-Drug Interactions with Warfarin

  • Chapter
  • First Online:
Oral Anticoagulation Therapy

Abstract

Days since initiation of a drug, which has potential drug-drug interaction with warfarin, is an important factor to account for in determining anticipated clinical effect, timing of monitoring, and potential dose adjustments. It is important to understand how to assess approaches to warfarin management in the presence of pharmacokinetic interactions such as pre-emptive dose adjustments and “watch and wait” with additional monitoring.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Le J. Overview of pharmacokinetics. Merck Manuals. 2016. http://www.merckmanuals.com/professional/clinical-pharmacology/pharmacokinetics/overview-of-pharmacokinetics

  2. Jacobs L. Warfarin pharmacology, clinical management, and evaluation of hemorrhagic risk for the elderly. Cardiol Clin. 2008;26:157–67.

    Article  PubMed  Google Scholar 

  3. Wells PS, Holbrook AM, Crowther NR, et al. Interactions of warfarin with drugs and food. Ann Intern Med. 1994;121(9):676–83.

    Article  CAS  PubMed  Google Scholar 

  4. Cropp JS, Bussey HI. A review of enzyme induction of warfarin metabolism with recommendations for patient management. Pharmacotherapy. 1997;17(5):917–28.

    CAS  PubMed  Google Scholar 

  5. Bungard TJ, Yakiwchuk E, Foisy M, et al. Drug interactions involving warfarin: practice tool and practical management tips. CPJ. 2011;144(1):21–5.

    Google Scholar 

  6. Lexi-Comp online. Lexi-Interactions. Hudson, OH: Lexi-Comp, Inc.; 2015. https://online.lexi.com/lco/action/interact. Accessed 20 June 2016.

  7. Levine M, Sheppard I. Biphasic interaction of phenytoin and warfarin. Clin Pharm. 1984;3(2):200–3.

    CAS  PubMed  Google Scholar 

  8. Hansen JM, Siersbaek-Nielsen K, Kristensen M, et al. Effect of diphenylhydantoin on the metabolism of dicoumarol in man. Acta Med Scand. 1971;189:15.

    Article  CAS  PubMed  Google Scholar 

  9. Phenytoin. Lexi-Comp online. Lexi-Drugs. Hudson, OH: Lexi-Comp, Inc.; 2015. https://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/7489. Accessed 20 June 2015.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rachel C. Ieuter PharmD, BCPS .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Ieuter, R.C. (2017). Pharmacokinetic Drug-Drug Interactions with Warfarin. In: Kiser, K. (eds) Oral Anticoagulation Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-54643-8_32

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-54643-8_32

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-54641-4

  • Online ISBN: 978-3-319-54643-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics