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Carcinogenesis of Laryngeal Tumors

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Mechanisms of Molecular Carcinogenesis – Volume 1

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Abstract

Laryngeal cancer is a rare disease comprising 1–2% of all malignancies with an incidence of 1.1% (men 2.1%, women 0.3%) and mortality of 1.0% worldwide with a geographical variability. Nevertheless, it is the most common of all malignant tumors in the upper aerodigestive tract. Similar to other head and neck regions, it develops in a variety of tissues from epithelial to neuroendocrine origin. In general, squamous carcinogenesis results from successive accumulation of molecular genetic alterations in the squamous epithelium lining the upper aerodigestive tract. Proteins related to cell proliferation and cell cycle regulation have been used (p53, p16, and cyclin D1) as markers of potential genetic results. Squamous cell carcinoma develops from the squamous mucosal lining of the upper aerodigestive tract mainly in patients with a history of abusing risk factors like cigarette smoking, alcohol abuse, or human papillomavirus. Only 20% of individuals with evident risk factors in the personal history, however, develop squamous cell carcinoma. As of today, extensive global research concerning signaling pathways, genetic studies, or carcinogenic mediators is ongoing with the aim of targeting tumor therapy in the future.

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Authors and Affiliations

  1. Division of Phoniatrics, Department of Otorhinolaryngology, Medical University of Graz, Speech and Swallowing, Auenbruggerplatz 26, Graz, 8036, Austria

    G. P. Hammer M.D.

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  1. G. P. Hammer M.D.
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  1. Department of Pathology, Medical Faculty, Otto von Guericke University Magdeburg, Magdeburg, Germany

    Johannes Haybaeck

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Hammer, G.P. (2017). Carcinogenesis of Laryngeal Tumors. In: Haybaeck, J. (eds) Mechanisms of Molecular Carcinogenesis – Volume 1. Springer, Cham. https://doi.org/10.1007/978-3-319-53659-0_14

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