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The Venous Connection: The Role of Veins in Neurodegenerative Disease

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Inflammatory Disorders of the Nervous System

Part of the book series: Current Clinical Neurology ((CCNEU))

Abstract

The cerebral venous drainage system has often been viewed simply as a series of collecting vessels passively channelling blood from the brain back to the heart. However, recent studies suggest that this system may be far from passive and that it plays an important role in regulating intracranial pressure and the stiffness of the brain parenchyma, as well as influencing the dynamics of the cerebrospinal fluid in the cranium. Anomalies of the cervical veins have been reportedly linked with several neurologic conditions, including multiple sclerosis, and this has led to renewed interest in the role of the cerebral venous system. In this review we investigate this issue and explore the connection between veins and neurologic disease, highlighting the biomechanical links between cerebral venous drainage and the intracranial fluidic system.

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Authors and Affiliations

  1. Buffalo Neuroimaging Analysis Center, Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, 100 High St, Buffalo, 14203, NY, USA

    Clive Beggs PhD

  2. Institute for Sport, Physical Activity and Leisure, Carnegie Faculty, Leeds Beckett University, Leeds, LS1 3HE, UK

    Clive Beggs PhD

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  1. Clive Beggs PhD
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Correspondence to Clive Beggs PhD .

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Editors and Affiliations

  1. Department of Neurology, LSU Health Sciences Center, Shreveport, Louisiana, USA

    Alireza Minagar

  2. Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, Louisiana, USA

    J. Steven Alexander

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Beggs, C. (2017). The Venous Connection: The Role of Veins in Neurodegenerative Disease. In: Minagar, A., Alexander, J. (eds) Inflammatory Disorders of the Nervous System. Current Clinical Neurology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-51220-4_13

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  • DOI: https://doi.org/10.1007/978-3-319-51220-4_13

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