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Cell Transplantation Therapy for Glaucoma

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Cellular Therapies for Retinal Disease

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Abstract

Glaucoma, a major cause of blindness, is a neurodegenerative disease characterized by progressive and irreversible loss of retinal ganglion cells and degeneration of optic nerve. Like other parts of the central nervous system, retinal ganglion cells do not regenerate. Current therapies may prevent or delay further damage, but cannot restore vision. Cell transplantation therapies hold great promise for slowing disease progression and restoring vision in glaucoma. Here, we summarize the current status of cell transplantation in glaucoma therapy. Accumulating evidence shows that transplanted cells can secrete and release neuroprotective factors to prevent or stop disease progression, and donor cells may replace lost cells and restore function. We further discuss the translational progress of cell transplantation for different cell types and the prospects of harnessing the endogenous regenerative potential of the eye. This discussion provides insights to achieve the goal of restoring vision in glaucoma using cell therapy.

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Authors and Affiliations

  1. Byers Eye Institute at Stanford University, 2452 Watson Court, Palo Alto, CA, 94303, USA

    Xiong Zhang Ph.D., Praseeda Venugopalan Ph.D. & Jeffrey L. Goldberg M.D., Ph.D.

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  1. Xiong Zhang Ph.D.
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  2. Praseeda Venugopalan Ph.D.
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  3. Jeffrey L. Goldberg M.D., Ph.D.
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Corresponding author

Correspondence to Jeffrey L. Goldberg M.D., Ph.D. .

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Editors and Affiliations

  1. Retina Division Chief; Department of Ophthalmology; Ahmanson Professor of Ophthalmology, Stein Eye Institute; David Geffen School of Medicine at UCLA, Los Angeles, California, USA

    Steven D. Schwartz

  2. Retina Division; Department of Ophthalmology, Stein Eye Institute; David Geffen School of Medicine at UCLA, Los Angeles, California, USA

    Aaron Nagiel

  3. Head of Astellas Global Regenerative Medicine, Chief Scientific Officer at the Astellas Institute for Regenerative Medicine, Marlborough, Massachusetts, USA

    Robert Lanza

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Zhang, X., Venugopalan, P., Goldberg, J.L. (2017). Cell Transplantation Therapy for Glaucoma. In: Schwartz, S., Nagiel, A., Lanza, R. (eds) Cellular Therapies for Retinal Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-49479-1_6

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