Skip to main content
SpringerLink
Log in

Light Chain Deposition Disease

  • Reference work entry
  • First Online:
Glomerulonephritis

Abstract

Monoclonal immunoglobulin deposition disease (MIDD) is a rare disorder characterized by the aberrant production and deposition of light and/or heavy chain immunoglobulins by clonal B-cell or plasma cell populations, resulting in multisystemic organ dysfunction. Renal disease is the most common initial disease manifestation, but other organs, such as the heart, lungs, liver, peripheral nerves, and skin, can be involved. Patients often present with nephrotic syndrome, hypertension, and an impaired glomerular filtration rate. Renal biopsy classically reveals nodular glomerulosclerosis on light microscopy, with non-congophilic, monotypic immunoglobulin deposits along the tubular and glomerular basement membranes by immunofluorescence and powdery and granular deposits on the basement membrane by electron microscopy. MIDD can be associated with multiple myeloma but may also be associated with a monoclonal gammopathy of renal significance, aparaprotein disorder of the kidney in patients who do not meet criteria for systemic lymphoma or multiple myeloma. The pathogenesis is related to an underlying clonal cell B or plasma cell population, the amount and primary structure of the abnormal light or heavy chain, as well as the interaction of the immunoglobulin with the local tissue environment. Treatment includes systemic chemotherapy and autologous stem cell transplantation to reduce the production of abnormal immunoglobulins. Bortezomib-based regimens have shown promise as a first-line therapy in MIDD. Renal transplantation has shown variable results due to the risk of recurrent disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 599.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 899.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Alexander MP, Nasr SH, Watson DC, Mendez GP, Rennke HG (2011) Renal crescentic alpha heavy chain deposition disease: a report of 3 cases and review of the literature. Am J Kidney Dis 58:621–625

    Article  PubMed  Google Scholar 

  • Aucouturier P, Khamlichi AA, Touchard G, Justrabo E, Cogne M, Chauffert B, Martin F, Preud’homme JL (1993) Brief report: heavy-chain deposition disease. N Engl J Med 329:1389–1393

    Article  CAS  PubMed  Google Scholar 

  • Bhargava P, Rushin JM, Rusnock EJ, Hefter LG, Franks TJ, Sabnis SG, Travis WD (2007) Pulmonary light chain deposition disease: report of five cases and review of the literature. Am J Surg Pathol 31:267–276

    Article  PubMed  Google Scholar 

  • Bonaud A, Bender S, Touchard G, Lacombe C, Srour N, Delpy L, Oblet C, Druilhe A, Quellard N, Javaugue V, Cogne M, Bridoux F, Sirac C (2015) A mouse model recapitulating human monoclonal heavy chain deposition disease evidences the relevance of proteasome inhibitor therapy. Blood 126:757–765

    Article  CAS  PubMed  Google Scholar 

  • Brockhurst I, Harris KP, Chapman CS (2005) Diagnosis and monitoring a case of light-chain deposition disease in the kidney using a new, sensitive immunoassay. Nephrol Dial Transplant: Off Publ Eur Dial Transplant Assoc Eur Ren Assoc 20:1251–1253

    Article  Google Scholar 

  • Buxbaum JN (2001) Abnormal immunoglobulin synthesis in monoclonal immunoglobulin light chain and light and heavy chain deposition disease. Amyloid: Int J Experiment Clin Invest: Off J Int Soc of Amyloid 8:84–93

    CAS  Google Scholar 

  • Buxbaum J, Gallo G (1999) Nonamyloidotic monoclonal immunoglobulin deposition disease. Light-chain, heavy-chain, and light- and heavy-chain deposition diseases. Hematol Oncol Clin North Am 13:1235–1248

    Article  CAS  PubMed  Google Scholar 

  • Buxbaum JN, Chuba JV, Hellman GC, Solomon A, Gallo GR (1990) Monoclonal immunoglobulin deposition disease: light chain and light and heavy chain deposition diseases and their relation to light chain amyloidosis. Clinical features, immunopathology, and molecular analysis. Ann Intern Med 112:455–464

    Article  CAS  PubMed  Google Scholar 

  • Buxbaum JN, Genega EM, Lazowski P, Kumar A, Tunick PA, Kronzon I, Gallo GR (2000) Infiltrative nonamyloidotic monoclonal immunoglobulin light chain cardiomyopathy: an underappreciated manifestation of plasma cell dyscrasias. Cardiology 93:220–228

    Article  CAS  PubMed  Google Scholar 

  • Casiraghi MA, De Paoli A, Assi A, Palladini G, Lavazza MT, Beretta A, Gualdoni G, Beretta R (2000) Hepatic amyloidosis with light chain deposition disease. A Rare Assoc Dig Liver Dis: Off J Ital Soc Gastroenterol Ital Assoc Study Liver 32:795–798

    Article  CAS  Google Scholar 

  • Chang A, Peutz-Kootstra CJ, Richardson CA, Alpers CE (2005) Expanding the pathologic spectrum of light chain deposition disease: a rare variant with clinical follow-up of 7 years. Mod Pathol: An Off J U S Can Acad Pathol Inc 18:998–1004

    Article  Google Scholar 

  • Cogne M, Preud’homme JL, Bauwens M, Touchard G, Aucouturier P (1991) Structure of a monoclonal kappa chain of the V kappa IV subgroup in the kidney and plasma cells in light chain deposition disease. J Clin Invest 87:2186–2190

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cohen C, Royer B, Javaugue V, Szalat R, El Karoui K, Caulier A, Knebelmann B, Jaccard A, Chevret S, Touchard G, Fermand JP, Arnulf B, Bridoux F (2015) Bortezomib produces high hematological response rates with prolonged renal survival in monoclonal immunoglobulin deposition disease. Kidney Int 88:1135–1143

    Article  CAS  PubMed  Google Scholar 

  • Colombat M, Stern M, Groussard O, Droz D, Brauner M, Valeyre D, Mal H, Taille C, Monnet I, Fournier M, Herson S, Danel C (2006) Pulmonary cystic disorder related to light chain deposition disease. Am J Respir Crit Care Med 173:777–780

    Article  PubMed  Google Scholar 

  • Confalonieri R, Barbiano Di Belgiojoso G, Banfi G, Ferrario F, Bertani T, Pozzi C, Casanova S, Lupo A, De Ferrari G, Minetti L (1988) Light chain nephropathy: histological and clinical aspects in 15 cases. Nephrol, Dial, Transplant: Off Publ Eur DialTransplant Assoc Eur Ren Assoc 3:150–156

    CAS  Google Scholar 

  • Copeland JN, Kouides PA, Grieff M, Nadasdy T (2003) Metachronous development of nonamyloidogenic [lambda] light chain deposition disease and IgG heavy chain amyloidosis in the same patient. Am J Surg Pathol 27:1477–1482

    Article  PubMed  Google Scholar 

  • Decourt C, Touchard G, Preud’homme JL, Vidal R, Beaufils H, Diemert MC, Cogne M (1998) Complete primary sequences of two lambda immunoglobulin light chains in myelomas with nonamyloid (Randall-type) light chain deposition disease. Am J Pathol 153:313–318

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Decourt A, Gondouin B, Delaroziere JC, Brunet P, Sallee M, Burtey S, Dussol B, Ivanov V, Costello R, Couchoud C, Jourde-Chiche N (2016) Trends in survival and renal recovery in patients with multiple myeloma or light-chain amyloidosis on chronic dialysis. Clin J Am Soc Nephrol: CJASN 11:431–441

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Denoroy L, Deret S, Aucouturier P (1994) Overrepresentation of the V kappa IV subgroup in light chain deposition disease. Immunol Lett 42:63–66

    Article  CAS  PubMed  Google Scholar 

  • Firkin F, Hill PA, Dwyer K, Gock H (2004) Reversal of dialysis-dependent renal failure in light-chain deposition disease by autologous peripheral blood stem cell transplantation. Am J Kidney Dis: Off J Natl Kidney Found 44:551–555

    Article  Google Scholar 

  • Fischer L, Korfel A, Stoltenburg-Didinger G, Ransco C, Thiel E (2006) A 19-year-old male with generalized seizures, unconsciousness and a deviation of gaze. Brain Pathol 16(185–6):187

    Google Scholar 

  • Fulton RB, Fernando SL (2009) Serum free light chain assay reduces the need for serum and urine immunofixation electrophoresis in the evaluation of monoclonal gammopathy. Ann Clin Biochem 46:407–412

    Article  CAS  PubMed  Google Scholar 

  • Ganeval D, Noel LH, Preud’homme JL, Droz D, Grunfeld JP (1984) Light-chain deposition disease: its relation with AL-type amyloidosis. Kidney Int 26:1–9

    Article  CAS  PubMed  Google Scholar 

  • Gertz MA, Lacy MQ, Dispenzieri A (2002) Immunoglobulin light chain amyloidosis and the kidney. Kidney Int 61:1–9

    Article  PubMed  Google Scholar 

  • Gokden N, Cetin N, Colakoglu N, Kumar J, Abul-Ezz S, Barlogie B, Liapis H, Walker PD (2007) Morphologic manifestations of combined light-chain deposition disease and light-chain cast nephropathy. Ultrastruct Pathol 31:141–149

    Article  PubMed  Google Scholar 

  • Gupta A, Helm TN (2002) Acquired cutis laxa associated with multiple myeloma. Cutis; Cutan Med Pract 69:114–118

    Google Scholar 

  • Harada K, Akai Y, Sakan H, Yamaguchi Y, Nakatani K, Iwano M, Saito Y (2010) Resolution of mesangial light chain deposits 3 years after high-dose melphalan with autologous peripheral blood stem cell transplantation. Clin Nephrol 74:384–388

    CAS  PubMed  Google Scholar 

  • Harrington CR, Beswick TC, Susa JS, Pandya AG (2008) Acquired cutis laxa associated with heavy chain deposition disease. J Am Acad Dermatol 59:S99–101

    Article  PubMed  Google Scholar 

  • Hassoun H, Flombaum C, D’agati VD, Rafferty BT, Cohen A, Klimek VM, Boruchov A, Kewalramani T, Reich L, Nimer SD, Comenzo RL (2008) High-dose melphalan and auto-SCT in patients with monoclonal Ig deposition disease. Bone Marrow Transplant 42:405–412

    Article  CAS  PubMed  Google Scholar 

  • Heilman RL, Velosa JA, Holley KE, Offord KP, Kyle RA (1992) Long-term follow-up and response to chemotherapy in patients with light-chain deposition disease. Am J Kidney Dis: Off J Natl Kidney Found 20:34–41

    Article  CAS  Google Scholar 

  • Herrera GA, Shultz JJ, Soong SJ, Sanders PW (1994) Growth factors in monoclonal light-chain-related renal diseases. Human Pathol 25:883–892

    Article  CAS  Google Scholar 

  • Herrera GA, Russell WJ, Isaac J, Turbat-Herrera EA, Tagouri YM, Sanders PW, Picken MM, Dempsey S (1999) Glomerulopathic light chain-mesangial cell interactions modulate in vitro extracellular matrix remodeling and reproduce mesangiopathic findings documented in vivo. Ultrastruct Pathol 23:107–126

    Article  CAS  PubMed  Google Scholar 

  • Highet AS (1980) Urticarial vasculitis and IgA myeloma. Br J Dermatol 102:355–357

    Article  CAS  PubMed  Google Scholar 

  • Hutchison CA, Plant T, Drayson M, Cockwell P, Kountouri M, Basnayake K, Harding S, Bradwell AR, Mead G (2008) Serum free light chain measurement aids the diagnosis of myeloma in patients with severe renal failure. BMC Nephrol 9:11

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hutchison CA, Batuman V, Behrens J, Bridoux F, Sirac C, Dispenzieri A, Herrera GA, Lachmann H, Sanders PW (2012) The pathogenesis and diagnosis of acute kidney injury in multiple myeloma. Nat Rev Nephrol 8:43–51

    Article  CAS  Google Scholar 

  • Jacquot C, Saint-Andre JP, Touchard G, Nochy D, D’auzac De Lamartinie C, Oriol R, Druet P, Bariety J (1985) Association of systemic light-chain deposition disease and amyloidosis: a report of three patients with renal involvement. Clin Nephrol 24:93–98

    CAS  PubMed  Google Scholar 

  • Kambham N, Markowitz GS, Appel GB, Kleiner MJ, Aucouturier P, D’agati VD (1999) Heavy chain deposition disease: the disease spectrum. Am J Kidney Dis: Off J Natl Kidney Found 33:954–962

    Article  CAS  Google Scholar 

  • Kaposztas Z, Kahan BD, Katz SM, Van Buren CT, Cherem L (2009) Bortezomib successfully reverses early recurrence of light-chain deposition disease in a renal allograft: a case report. Transplant Proc 41:4407–4410

    Article  CAS  PubMed  Google Scholar 

  • Kastritis E, Migkou M, Gavriatopoulou M, Zirogiannis P, Hadjikonstantinou V, Dimopoulos MA (2009) Treatment of light chain deposition disease with bortezomib and dexamethasone. Haematologica 94:300–302

    Article  CAS  PubMed  Google Scholar 

  • Katzmann JA, Kyle RA, Benson J, Larson DR, Snyder MR, Lust JA, Rajkumar SV, Dispenzieri A (2009) Screening panels for detection of monoclonal gammopathies. Clin Chem 55:1517–1522

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Keeling J, Herrera GA (2005) Matrix metalloproteinases and mesangial remodeling in light chain-related glomerular damage. Kidney Int 68:1590–1603

    Article  CAS  PubMed  Google Scholar 

  • Keeling J, Herrera GA (2009) An in vitro model of light chain deposition disease. Kidney Int 75:634–645

    Article  CAS  PubMed  Google Scholar 

  • Keeling WB, Armstrong PA, Stone PA, Bandyk DF, Shames ML (2005) An overview of matrix metalloproteinases in the pathogenesis and treatment of abdominal aortic aneurysms. Vasc Endovascular Surg 39:457–464

    Article  PubMed  Google Scholar 

  • Khamlichi AA, Aucouturier P, Preud’homme JL, Cogne M (1995a) Structure of abnormal heavy chains in human heavy-chain-deposition disease. Eur J Biochem/FEBS 229:54–60

    Article  CAS  Google Scholar 

  • Khamlichi AA, Rocca A, Touchard G, Aucouturier P, Preud’homme JL, Cogne M (1995b) Role of light chain variable region in myeloma with light chain deposition disease: evidence from an experimental model. Blood 86:3655–3659

    Article  CAS  PubMed  Google Scholar 

  • Khoor A, Myers JL, Tazelaar HD, Kurtin PJ (2004) Amyloid-like pulmonary nodules, including localized light-chain deposition: clinicopathologic analysis of three cases. Am J Clin Pathol 121:200–204

    Article  PubMed  Google Scholar 

  • Knittler MR, Haas IG (1992) Interaction of BiP with newly synthesized immunoglobulin light chain molecules: cycles of sequential binding and release. EMBO J 11:1573–1581

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Komatsuda A, Wakui H, Ohtani H, Kodama T, Miki K, Imai H, Miura AB (2000) Disappearance of nodular mesangial lesions in a patient with light chain nephropathy after long-term chemotherapy. Am J Kidney Dis: Off J Natl Kidney Found 35:E9

    Article  CAS  Google Scholar 

  • Kuppachi S, Holanda D, Thomas CP (2016) Light chain deposition disease after kidney transplantation with long graft survival: case report. Transplant Proc 48:255–258

    Article  CAS  PubMed  Google Scholar 

  • Leung N, Lager DJ, Gertz MA, Wilson K, Kanakiriya S, Fervenza FC (2004) Long-term outcome of renal transplantation in light-chain deposition disease. Am J Kidney Dis: Off J Natl Kidney Found 43:147–153

    Article  Google Scholar 

  • Leung N, Bridoux F, Hutchison CA, Nasr SH, Cockwell P, Fermand JP, Dispenzieri A, Song KW, Kyle RA (2012a) Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant. Blood 120:4292–4295

    Article  CAS  PubMed  Google Scholar 

  • Leung N, Gertz M, Kyle RA, Fervenza FC, Irazabal MV, Eirin A, Kumar S, Cha SS, Rajkumar SV, Lacy MQ, Zeldenrust SR, Buadi FK, Hayman SR, Nasr SH, Sethi S, Ramirez-Alvarado M, Witzig TE, Herrmann SM, Dispenzieri A (2012b) Urinary albumin excretion patterns of patients with cast nephropathy and other monoclonal gammopathy-related kidney diseases. Clin J Am Soc Nephrol: CJASN 7:1964–1968

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liapis H, Papadakis I, Nakopoulou L (2000) Nodular glomerulosclerosis secondary to mu heavy chain deposits. Hum Pathol 31:122–125

    Article  CAS  PubMed  Google Scholar 

  • Lin J, Markowitz GS, Valeri AM, Kambham N, Sherman WH, Appel GB, D’agati VD (2001) Renal monoclonal immunoglobulin deposition disease: the disease spectrum. J Am Soc Nephrol: JASN 12:1482–1492

    Article  CAS  PubMed  Google Scholar 

  • Lorenz EC, Sethi S, Poshusta TL, Ramirez-Alvarado M, Kumar S, Lager DJ, Fervenza FC, Leung N (2010) Renal failure due to combined cast nephropathy, amyloidosis and light-chain deposition disease. Nephrol Dial Transplant: Off Publ Eur Dial Transplant Assoc Eur Ren Assoc 25:1340–1343

    Article  Google Scholar 

  • Makis W, Derbekyan V, Novales-Diaz JA (2010) Pulmonary light and heavy chain deposition disease: a pitfall for lung cancer evaluation with F-18 FDG PET/CT. Clin Nucl Med 35:640–643

    Article  PubMed  Google Scholar 

  • Merlini G, Stone MJ (2006) Dangerous small B-cell clones. Blood 108:2520–2530

    Article  CAS  PubMed  Google Scholar 

  • Michopoulos S, Petraki K, Petraki C, Dimopoulos MA (2002) Light chain deposition disease of the liver without renal involvement in a patient with multiple myeloma related to liver failure and rapid fatal outcome. Dig Dis Sci 47:730–734

    Article  PubMed  Google Scholar 

  • Miletic VD, Frank MM (1995) Complement-immunoglobulin interactions. Curr Opin Immunol 7:41–47

    Article  CAS  PubMed  Google Scholar 

  • Moiz A, Javed T, Garces J, Staffeld-Coit C, Paueksakon P (2014) Late recurrence of light chain deposition disease after kidney transplantation treated with bortezomib: a case report. Ochsner J 14:445–449

    PubMed  PubMed Central  Google Scholar 

  • Montseny JJ, Kleinknecht D, Meyrier A, Vanhille P, Simon P, Pruna A, Eladari D (1998) Long-term outcome according to renal histological lesions in 118 patients with monoclonal gammopathies. Nephrol Dial Transplant: Off Publ Eur Dial Transplant Assoc Eur Ren Assoc 13:1438–1445

    Article  CAS  Google Scholar 

  • Moulin B, Deret S, Mariette X, Kourilsky O, Imai H, Dupouet L, Marcellin L, Kolb I, Aucouturier P, Brouet JC, Ronco PM, Mougenot B (1999) Nodular glomerulosclerosis with deposition of monoclonal immunoglobulin heavy chains lacking C(H)1. J Am Soc Nephrol: JASN 10:519–528

    Article  CAS  PubMed  Google Scholar 

  • Nakamura M, Satoh M, Kowada S, Satoh H, Tashiro A, Sato F, Masuda T, Hiramori K (2002) Reversible restrictive cardiomyopathy due to light-chain deposition disease. Mayo Clin Proc Mayo Clin 77:193–196

    Article  PubMed  Google Scholar 

  • Nasr SH, Valeri AM, Cornell LD, Fidler ME, Sethi S, D’agati VD, Leung N (2012) Renal monoclonal immunoglobulin deposition disease: a report of 64 patients from a single institution. Clin J Am Soc Nephrol: CJASN 7:231–239

    Article  PubMed  Google Scholar 

  • Nasr SH, Valeri AM, Sethi S, Fidler ME, Cornell LD, Gertz MA, Lacy M, Dispenzieri A, Rajkumar SV, Kyle RA Leung N (2012) Clinicopathologic correlations in multiple myeloma: a case series of 190 patients with kidney biopsies. Am J Kidney Dis 59(6):786–94.

    Article  PubMed  Google Scholar 

  • Pantazis G, Psaras T, Krope K, Von Coelln R, Fend F, Bock T, Schittenhelm J, Melms A, Meyermann R, Bornemann A (2010) Cerebral low-grade lymphoma and light chain deposition disease: exceedingly high IgG levels in the cerebrospinal fluid as a diagnostic clue. Clin Neuropathol 29:378–383

    Article  CAS  PubMed  Google Scholar 

  • Patel K, Dillon JJ, Leung N, Bomback AS, Appel GB, D’agati V, Canetta PA (2014) Use of bortezomib in heavy-chain deposition disease: a report of 3 cases. Am J Kidney Dis: Off J Natl Kidney Found 64:123–127

    Article  CAS  Google Scholar 

  • Popovic M, Tavcar R, Glavac D, Volavsek M, Pirtosek Z, Vizjak A (2007) Light chain deposition disease restricted to the brain: the first case report. Hum Pathol 38:179–184

    Article  CAS  PubMed  Google Scholar 

  • Pozzi C, Fogazzi GB, Banfi G, Strom EH, Ponticelli C, Locatelli F (1995) Renal disease and patient survival in light chain deposition disease. Clin Nephrol 43:281–287

    CAS  PubMed  Google Scholar 

  • Pozzi C, D’amico M, Fogazzi GB, Curioni S, Ferrario F, Pasquali S, Quattrocchio G, Rollino C, Segagni S, Locatelli F (2003) Light chain deposition disease with renal involvement: clinical characteristics and prognostic factors. Am J Kidney Dis: Off J Natl Kidney Found 42:1154–1163

    Article  Google Scholar 

  • Randall RE, Williamson WC Jr, Mullinax F, Tung MY, Still WJ (1976) Manifestations of systemic light chain deposition. Am J Med 60:293–299

    Article  CAS  PubMed  Google Scholar 

  • Rho L, Qiu L, Strauchen JA, Gordon RE, Teirstein AS (2009) Pulmonary manifestations of light chain deposition disease. Respirology 14:767–770

    Article  PubMed  Google Scholar 

  • Rocca A, Khamlichi AA, Aucouturier P, Noel LH, Denoroy L, Preud’homme JL, Cogne M (1993) Primary structure of a variable region of the V kappa I subgroup (ISE) in light chain deposition disease. Clin Exp Immunol 91:506–509

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ronco P, Plaisier E, Mougenot B, Aucouturier P (2006) Immunoglobulin light (heavy)-chain deposition disease: from molecular medicine to pathophysiology-driven therapy. Clin J Am Soc Nephrol: CJASN 1:1342–1350

    Article  CAS  PubMed  Google Scholar 

  • Royal V, Quint P, Leblanc M, Leblanc R, Duncanson GF, Perrizo RL, Fervenza FC, Kurtin P, Sethi S (2015) IgD heavy-chain deposition disease: detection by laser microdissection and mass spectrometry. J Am Soc Nephrol: JASN 26:784–790

    Article  CAS  PubMed  Google Scholar 

  • Royer B, Arnulf B, Martinez F, Roy L, Flageul B, Etienne I, Ronco P, Brouet JC, Fermand JP (2004) High dose chemotherapy in light chain or light and heavy chain deposition disease. Kidney Int 65:642–648

    Article  CAS  PubMed  Google Scholar 

  • Sayed RH, Wechalekar AD, Gilbertson JA, Bass P, Mahmood S, Sachchithanantham S, Fontana M, Patel K, Whelan CJ, Lachmann HJ, Hawkins PN, Gillmore JD (2015) Natural history and outcome of light chain deposition disease. Blood 126:2805–2810

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sethi S, Vrana JA, Theis JD, Leung N, Sethi A, Nasr SH, Fervenza FC, Cornell LD, Fidler ME, Dogan A (2012) Laser microdissection and mass spectrometry-based proteomics aids the diagnosis and typing of renal amyloidosis. Kidney Int 82:226–234

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Short AK, O’donoghue DJ, Riad HN, Short CD, Roberts IS (2001) Recurrence of light chain nephropathy in a renal allograft. Case Rep Rev Lit Am J Nephrol 21:237–240

    CAS  Google Scholar 

  • Sicard A, Karras A, Goujon JM, Sirac C, Bender S, Labatut D, Callard P, Sarkozy C, Essig M, Vanhille P, Provot F, Nony A, Nochy D, Ronco P, Bridoux F, Touchard G (2014) Light chain deposition disease without glomerular proteinuria: a diagnostic challenge for the nephrologist. Nephrol Dial Transplant: Off Publ Eur Dial Transplant Assoc – Eur Ren Assoc 29:1894–1902

    Article  CAS  Google Scholar 

  • Soma J, Sato K, Sakuma T, Saito H, Sato H, Sato T, Abbas A, Aucouturier P (2004) Immunoglobulin gamma3-heavy-chain deposition disease: report of a case and relationship with hypocomplementemia. Am J Kidney Dis: Off J Natl Kidney Found 43:E10–E16

    Article  Google Scholar 

  • Strom EH, Fogazzi GB, Banfi G, Pozzi C, Mihatsch MJ (1994) Light chain deposition disease of the kidney. Morphological aspects in 24 patients. Virchows Arch : Int J Pathol 425:271–280

    Article  CAS  Google Scholar 

  • Tan S, Pon K, Bargman J, Ghazarian D (2003) Generalized cutis laxa associated with heavy chain deposition disease. J Cutan Med Surg 7:390–394

    Article  PubMed  Google Scholar 

  • Telio D, Shepherd J, Forrest D, Zypchen L, Barnett M, Nevill T, Song KW (2012) High-dose melphalan followed by ASCT has favorable safety and efficacy in selected patients with light chain deposition disease and light and heavy chain deposition disease. Bone Marrow Transplant 47:453–455

    Article  PubMed  CAS  Google Scholar 

  • Truong LD, Pindur J, Barrios R, D’agati V, Lechago J, Suki W, Majesky M (1994) Tenascin is an important component of the glomerular extracellular matrix in normal and pathologic conditions. Kidney Int 45:201–210

    Article  CAS  PubMed  Google Scholar 

  • Tubbs RR, Berkley V, Valenzuela R, Mcmahon JT, Gephardt GN, Fishleder AJ, Nally JV, Pohl MA, Bukowski RM, Lichtin AE (1992) Pseudo-gamma heavy chain (IgG4 lambda) deposition disease. Mod Pathol: Off J U S Can Acad Pathol Inc 5:185–190

    CAS  Google Scholar 

  • Vidal R, Goni F, Stevens F, Aucouturier P, Kumar A, Frangione B, Ghiso J, Gallo G (1999) Somatic mutations of the L12a gene in V-kappa(1) light chain deposition disease: potential effects on aberrant protein conformation and deposition. Am J Pathol 155:2009–2017

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Weichman K, Dember LM, Prokaeva T, Wright DG, Quillen K, Rosenzweig M, Skinner M, Seldin DC, Sanchorawala V (2006) Clinical and molecular characteristics of patients with non-amyloid light chain deposition disorders, and outcome following treatment with high-dose melphalan and autologous stem cell transplantation. Bone Marrow Transplant 38:339–343

    Article  CAS  PubMed  Google Scholar 

  • Yadav P, Leung N, Sanders PW, Cockwell P (2015) The use of immunoglobulin light chain assays in the diagnosis of paraprotein-related kidney disease. Kidney Int 87:692–697

    Article  CAS  PubMed  Google Scholar 

  • Yasuda T, Fujita K, Imai H, Morita K, Nakamoto Y, Miura AB (1995) Gamma-heavy chain deposition disease showing nodular glomerulosclerosis. Clin Nephrol 44:394–399

    CAS  PubMed  Google Scholar 

  • Zakrzewski PA, Weis E, White VA, Rootman J (2010) Intracellular extraocular muscle light- and heavy-chain deposition disease contributing to compressive optic neuropathy in a patient with preexisting Graves’ orbitopathy. Ophthalmol J Int Ophtalmol Int J Ophthalmol Zeitschrift fur Augenheilkunde 224:59–62

    Article  Google Scholar 

  • Zand L, Nasr SH, Gertz MA, Dispenzieri A, Lacy MQ, Buadi FK, Kumar S, Kyle RA, Fervenza FC, Sethi S, Dingli D, Rajkumar SV, Kapoor P, Mccurdy A, Leung N (2015) Clinical and prognostic differences among patients with light chain deposition disease, myeloma cast nephropathy and both. Leuk Lymphoma 56:3357–3364

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA

    Andrea Kattah & Nelson Leung

  2. Division of Hematology, Mayo Graduate School of Medicine, Mayo Clinic, Rochester, MN, USA

    Nelson Leung

Authors
  1. Andrea Kattah
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nelson Leung
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nelson Leung .

Editor information

Editors and Affiliations

  1. Department of Pediatrics, NYU Langone Medical Center, New York, NY, USA

    Howard Trachtman

  2. Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA

    Leal C. Herlitz

  3. Nephrology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA

    Edgar V. Lerma

  4. Renal, Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Jonathan J. Hogan

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Kattah, A., Leung, N. (2019). Light Chain Deposition Disease. In: Trachtman, H., Herlitz, L., Lerma, E., Hogan, J. (eds) Glomerulonephritis. Springer, Cham. https://doi.org/10.1007/978-3-319-49379-4_39

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-49379-4_39

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-49378-7

  • Online ISBN: 978-3-319-49379-4

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation