Skip to main content
SpringerLink
Log in

Clinical Utility of Prognostic Scoring Systems in Patients with Hematological Malignancies Who Require Mechanical Ventilation

  • Chapter
  • First Online:
Mechanical Ventilation in Critically Ill Cancer Patients

  • 853 Accesses

Abstract

Patients with hematological malignancies can develop acute respiratory failure (ARF) due to lung injury by chemotherapeutic agents and blood product transfusion, infection, neuromuscular weakness, and fluid overload. At the time of ICU admission, it can be difficult to predict which of these patients will benefit from invasive mechanical ventilation and will survive their episode of ARF. In this chapter, we review prognostic scoring systems that have been applied to this set of clinical circumstances, the results of studies evaluating mortality risk factors for critically ill patients with hematological malignancies, and unanswered questions regarding the provision of invasive and noninvasive mechanical ventilatory support to these patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  1. Smith A, Howell D, Patmore R, Jack A, Roman E. Incidence of haematological malignancy by sub-type: a report from the Haematological Malignancy Research Network. Br J Cancer. 2011;105:1684–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Hayat MJ, Howlader N, Reichman ME, Edwards BK. Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) Program. Oncologist. 2007;12:20–37.

    Article  PubMed  Google Scholar 

  3. Massion PB, Dive AM, Doyen C, Bulpa P, Jamart J, Bosly A, Installe E. Prognosis of hematologic malignancies does not predict intensive care unit mortality. Crit Care Med. 2002;30:2260–70.

    Article  PubMed  Google Scholar 

  4. Kroschinsky F, Weise M, Illmer T, Haenel M, Bornhaeuser M, Hoeffken G, Ehninger G, Schuler U. Outcome and prognostic features of intensive care unit treatment in patients with hematological malignancies. Intensive Care Med. 2002;28:1294–300.

    Article  PubMed  Google Scholar 

  5. Azoulay E, Mokart D, Pene F, Lambert J, Kouatchet A, Mayaux J, Vincent F, Nyunga M, Bruneel F, Laisne LM, Rabbat A, Lebert C, Perez P, Chaize M, Renault A, Meert AP, Benoit D, Hamidfar R, Jourdain M, Darmon M, Schlemmer B, Chevret S, Lemiale V. Outcomes of critically ill patients with hematologic malignancies: prospective multicenter data from France and Belgium—a groupe de recherche respiratoire en reanimation onco-hematologique study. J Clin Oncol. 2013;31:2810–8.

    Article  PubMed  Google Scholar 

  6. Benoit DD, Vandewoude KH, Decruyenaere JM, Hoste EA, Colardyn FA. Outcome and early prognostic indicators in patients with a hematologic malignancy admitted to the intensive care unit for a life-threatening complication. Crit Care Med. 2003;31:104–12.

    Article  PubMed  Google Scholar 

  7. Wunsch H, Guerra C, Barnato AE, Angus DC, Li G, Linde-Zwirble WT. Three-year outcomes for Medicare beneficiaries who survive intensive care. JAMA. 2010;303:849–56.

    Article  CAS  PubMed  Google Scholar 

  8. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med. 2007;35:1244–50.

    Article  PubMed  Google Scholar 

  9. Hampshire PA, Welch CA, McCrossan LA, Francis K, Harrison DA. Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: a secondary analysis of the ICNARC Case Mix Programme Database. Crit Care. 2009;13:R137.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Bird GT, Farquhar-Smith P, Wigmore T, Potter M, Gruber PC. Outcomes and prognostic factors in patients with haematological malignancy admitted to a specialist cancer intensive care unit: a 5 yr study. Br J Anaesth. 2012. https://doi.org/10.1093/bja/aer449.

  11. Grgic Medic M, Gornik I, Gasparovic V. Hematologic malignancies in the medical intensive care unit—outcomes and prognostic factors. Hematology. 2015;20:247–53.

    Article  PubMed  Google Scholar 

  12. Vlaar AP, Juffermans NP. Transfusion-related acute lung injury: a clinical review. Lancet. 2013;382:984–94.

    Article  PubMed  Google Scholar 

  13. van Stein D, Beckers EA, Sintnicolaas K, Porcelijn L, Danovic F, Wollersheim JA, Brand A, van Rhenen DJ. Transfusion-related acute lung injury reports in the Netherlands: an observational study. Transfusion. 2010;50:213–20.

    Article  PubMed  Google Scholar 

  14. Mulder HD, Augustijn QJ, van Woensel JB, Bos AP, Juffermans NP, Wosten-van Asperen RM. Incidence, risk factors, and outcome of transfusion-related acute lung injury in critically ill children: a retrospective study. J Crit Care. 2015;30:55–9.

    Article  PubMed  Google Scholar 

  15. Vlaar AP, Wolthuis EK, Hofstra JJ, Roelofs JJ, Boon L, Schultz MJ, Lutter R, Juffermans NP. Mechanical ventilation aggravates transfusion-related acute lung injury induced by MHC-I class antibodies. Intensive Care Med. 2010;36:879–87.

    Article  CAS  PubMed  Google Scholar 

  16. Muller MC, Tuinman PR, van der Sluijs KF, Boon L, Roelofs JJ, Vroom MB, Juffermans NP. Methylprednisolone fails to attenuate lung injury in a mouse model of transfusion related acute lung injury. Transfusion. 2014;54:996–1001.

    Article  PubMed  Google Scholar 

  17. Rana R, Fernandez-Perez ER, Khan SA, Rana S, Winters JL, Lesnick TG, Moore SB, Gajic O. Transfusion-related acute lung injury and pulmonary edema in critically ill patients: a retrospective study. Transfusion. 2006;46:1478–83.

    Article  PubMed  Google Scholar 

  18. Sykes E, Cosgrove JF, Nesbitt ID, O'Suilleabhain CB. Early noncardiogenic pulmonary edema and the use of PEEP and prone ventilation after emergency liver transplantation. Liver Transpl. 2007;13:459–62.

    Article  CAS  PubMed  Google Scholar 

  19. Cantlay K, Clarke M, Wallis J, Cosgrove JF. Immediate postoperative prone ventilation in the management of transfusion-related acute lung injury (TRALI) following infra-renal abdominal aortic aneurysm repair. Anaesth Intensive Care. 2006;34:521–2.

    CAS  PubMed  Google Scholar 

  20. Oprea AD, Russell RR, Russell KS, Abu-Khalaf M. Chemotherapy agents with known cardiovascular side effects and their anesthetic implications. J Cardiothorac Vasc Anesth. 2015. https://doi.org/10.1053/j.jvca.2015.06.020.

  21. Vahid B, Marik PE. Pulmonary complications of novel antineoplastic agents for solid tumors. Chest. 2008;133:528–38.

    Article  CAS  PubMed  Google Scholar 

  22. Tonorezos ES, Stillwell EE, Calloway JJ, Glew T, Wessler JD, Rebolledo BJ, Pham A, Steingart RM, Lazarus H, Gale RP, Jakubowski AA, Schaffer WL. Arrhythmias in the setting of hematopoietic cell transplants. Bone Marrow Transplant. 2015;50:1212–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Azoulay E, Thiery G, Chevret S, Moreau D, Darmon M, Bergeron A, Yang K, Meignin V, Ciroldi M, Le Gall JR, Tazi A, Schlemmer B. The prognosis of acute respiratory failure in critically ill cancer patients. Medicine (Baltimore). 2004;83:360–70.

    Article  Google Scholar 

  24. Wohlfarth P, Ullrich R, Staudinger T, Bojic A, Robak O, Hermann A, Lubsczyk B, Worel N, Fuhrmann V, Schoder M, Funovics M, Rabitsch W, Knoebl P, Laczika K, Locker GJ, Sperr WR, Schellongowski P, Arbeitsgruppe fur hamato-onkologische Intensivmedizin der Osterreichischen Gesellschaft fur Internistische und Allgemeine Intensivmedizin und N. Extracorporeal membrane oxygenation in adult patients with hematologic malignancies and severe acute respiratory failure. Crit Care. 2014;18:R20.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA. 1993;270:2957–63.

    Article  PubMed  Google Scholar 

  26. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996;22:707–10.

    Article  CAS  PubMed  Google Scholar 

  27. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13:818–29.

    Article  CAS  PubMed  Google Scholar 

  28. Medeiros PB, Monteiro M, Cardoso T, Campello GC. The accuracy of SAPS II and SOFA score to predict mortality in immunosuppressed patients admitted in intensive care. Intensive Care Med Exp. 2015;3:A526.

    Article  PubMed Central  Google Scholar 

  29. Sawicka W, Owczuk R, Wujtewicz MA, Wujtewicz M. The effectiveness of the APACHE II, SAPS II and SOFA prognostic scoring systems in patients with haematological malignancies in the intensive care unit. Anaesthesiol Intensive Ther. 2014;46:166–70.

    Article  PubMed  Google Scholar 

  30. Geerse DA, Span LF, Pinto-Sietsma SJ, van Mook WN. Prognosis of patients with haematological malignancies admitted to the intensive care unit: Sequential Organ Failure Assessment (SOFA) trend is a powerful predictor of mortality. Eur J Intern Med. 2011;22:57–61.

    Article  PubMed  Google Scholar 

  31. Duayer I, Osawa E, Park C, Fukushima J, Almeida J, Nakamura R, Galas F, Hajjar L. Outcomes of patients with hematologic malignancies admitted to the ICU. Crit Care. 2015;19:1–201.

    Article  Google Scholar 

  32. Adda M, Coquet I, Darmon M, Thiery G, Schlemmer B, Azoulay E. Predictors of noninvasive ventilation failure in patients with hematologic malignancy and acute respiratory failure. Crit Care Med. 2008;36:2766–72.

    Article  PubMed  Google Scholar 

  33. Gristina GR, Antonelli M, Conti G, Ciarlone A, Rogante S, Rossi C, Bertolini G, GiViTi. Noninvasive versus invasive ventilation for acute respiratory failure in patients with hematologic malignancies: a 5-year multicenter observational survey. Crit Care Med. 2011;39:2232–9.

    Article  PubMed  Google Scholar 

  34. Molina R, Bernal T, Borges M, Zaragoza R, Bonastre J, Granada RM, Rodriguez-Borregan JC, Nunez K, Seijas I, Ayestaran I, Albaiceta GM, investigators Es. Ventilatory support in critically ill hematology patients with respiratory failure. Crit Care. 2012;16:R133.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Lemiale V, Resche-Rigon M, Mokart D, Pene F, Rabbat A, Kouatchet A, Vincent F, Bruneel F, Nyunga M, Lebert C, Perez P, Meert AP, Benoit D, Chevret S, Azoulay E. Acute respiratory failure in patients with hematological malignancies: outcomes according to initial ventilation strategy. A groupe de recherche respiratoire en reanimation onco-hematologique (Grrr-OH) study. Ann Intensive Care. 2015;5:28.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Quon BS, Gan WQ, Sin DD. Contemporary management of acute exacerbations of COPD: a systematic review and metaanalysis. Chest. 2008;133:756–66.

    Article  PubMed  Google Scholar 

  37. Vital FM, Ladeira MT, Atallah AN. Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema. Cochrane Database Syst Rev. 2013. https://doi.org/10.1002/14651858.CD005351.pub3:CD005351.

  38. Schnell D, Lemiale V, Azoulay E. Non-invasive mechanical ventilation in hematology patients: let's agree on several things first. Crit Care. 2012;16:175.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Bruck P, Pierzchlewska M, Kaluzna-Oleksy M, Ramos Lopez ME, Rummel M, Hoelzer D, Bohme A. Dying of hematologic patients—treatment characteristics in a German University Hospital. Support Care Cancer. 2012;20:2895–902.

    Article  PubMed  Google Scholar 

  40. Hui D, Didwaniya N, Vidal M, Shin SH, Chisholm G, Roquemore J, Bruera E. Quality of end-of-life care in patients with hematologic malignancies: a retrospective cohort study. Cancer. 2014;120:1572–8.

    Article  PubMed  PubMed Central  Google Scholar 

  41. LeBlanc TW. Palliative care and hematologic malignancies: old dog, new tricks? J Oncol Pract. 2014;10:e404–7.

    Article  PubMed  Google Scholar 

  42. Odejide OO, Cronin AM, Condron NB, Fletcher SA, Earle CC, Tulsky JA, Abel GA. Barriers to quality end-of-life care for patients with blood cancers. J Clin Oncol. 2016. https://doi.org/10.1200/JCO.2016.67.8177.

  43. Aslakson RA, Curtis JR, Nelson JE. The changing role of palliative care in the ICU. Crit Care Med. 2014;42:2418–28.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Pulmonary and Critical Care Medicine, 5C, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH, USA

    Elliot D. Backer M.D. & Alex H. Gifford M.D.

Authors
  1. Elliot D. Backer M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alex H. Gifford M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alex H. Gifford M.D. .

Editor information

Editors and Affiliations

  1. Intensive Care and Non Invasive Ventilatory Unit, Hospital Morales Meseguer, Murcia, Spain

    Antonio M. Esquinas

  2. Division of Anesthesiology and Critical Care, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    S. Egbert Pravinkumar

  3. Wayne State University School of Medicine, Detroit, Michigan, USA

    AYMAN O. SOUBANI

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Backer, E.D., Gifford, A.H. (2018). Clinical Utility of Prognostic Scoring Systems in Patients with Hematological Malignancies Who Require Mechanical Ventilation. In: Esquinas, A., Pravinkumar, S., SOUBANI, A. (eds) Mechanical Ventilation in Critically Ill Cancer Patients. Springer, Cham. https://doi.org/10.1007/978-3-319-49256-8_32

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-49256-8_32

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-49255-1

  • Online ISBN: 978-3-319-49256-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation