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Malignant Tumors Arising in Inflammatory Bowel Disease

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Pediatric Inflammatory Bowel Disease

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Abstract

Inflammatory bowel disease (IBD) patients have an increased risk for colorectal cancer (CRC). While not always appreciated, this is true not just for patients with ulcerative colitis (UC) but also patients with Crohn’s disease, particularly those with Crohn’s colitis. While our understanding of the clinical and molecular basis for this association has improved since the first case descriptions and series were reported nearly a century ago, our means of prevention and treatment, primarily colonoscopic surveillance and prophylactic surgery, remain modest, though circumstantial evidence supports their use. Colorectal cancer still accounts for a large proportion of the premature mortality in both UC and Crohn’s disease (CD).

This chapter will review the pathogenesis and clinical epidemiology of colorectal cancer in inflammatory bowel disease (IBD), as well as the theoretical and literature-based strategies for CRC prevention. Additionally, the available evidence on the association between Crohn’s ileitis and small intestinal cancer will be presented.

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Authors and Affiliations

  1. The Dr. Henry D. Janowitz Division of Gastroenterology, The Mount Sinai School of Medicine, New York, NY, USA

    Thomas A. Ullman MD

  2. Memorial Sloan Kettering Cancer Center, New York, NY, 10024, USA

    Rona Yaeger MD

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  1. Thomas A. Ullman MD
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  2. Rona Yaeger MD
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Correspondence to Thomas A. Ullman MD .

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Editors and Affiliations

  1. Division of GI, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Petar Mamula

  2. Division of GI, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Andrew B. Grossman

  3. Division of GI, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Robert N. Baldassano

  4. Division of GI, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Judith R. Kelsen

  5. Division of Pediatric Gastroenterology & Nutrition, University of South Carolina School of Medicine - Greenville, Greenville, South Carolina, USA

    Jonathan E. Markowitz

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Ullman, T.A., Yaeger, R. (2017). Malignant Tumors Arising in Inflammatory Bowel Disease. In: Mamula, P., Grossman, A., Baldassano, R., Kelsen, J., Markowitz, J. (eds) Pediatric Inflammatory Bowel Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-49215-5_55

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