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Mathematical Analysis of Regulatory Networks and Damage Repair Efficiency in Bacterial Cells

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Genetics, Evolution and Radiation

Abstract

An extended mathematical model of the UV-induced mutation process in E. coli bacterial cells has been developed. It describes the whole sequence of molecular events involved in nucleotide excision repair of initial damage, replication kinetics and postreplication repair. The model provides ab initio calculation of the number of mismatches as a result of translesion synthesis for both wild type and repair-deficient mutant cells. A comparison of efficiency of different repair systems has been carried out.

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References

  • Aksenov SV (1999) Dynamics of the inducing signal for the SOS regulatory system in Escherichia coli after ultraviolet irradiation. Math Biosci 157:269–286

    Article  CAS  PubMed  Google Scholar 

  • Bates H, Randall SK, Rayssiguier C, Bridges BA, Goodman MF, Radman M (1989) Spontaneous and UV-Induced mutations in Escherichia coli K-12 strains with altered or absent DNA polymerase I. J Bacteriol 171:2480–2484

    Google Scholar 

  • Belov OV, Krasavin EA, Parkhomenko AYu (2009) Model of SOS-induced mutagenesis in bacteria Escherichia coli under ultraviolet irradiation. J Theor Biol 261:388–395

    Article  CAS  PubMed  Google Scholar 

  • Bugay AN, Krasavin EA, Parkhomenko AYu, Vasilyeva MA (2015) Modeling nucleotide excision repair and its impact on UV-induced mutagenesis during SOS-response in bacterial cells. J Theor Biol 364:7–20

    Article  CAS  PubMed  Google Scholar 

  • Cadet J, Anselmino C, Douki T, Voituriez L (1992) Photochemistry of nucleic acids in cells. J Photochem Photobiol B 15:277–298

    Article  CAS  PubMed  Google Scholar 

  • Friedman N, Vardi S, Ronen M, Alon U, Stavans J (2005) Precise temporal modulation in the response the SOS DNA repair network in individual bacteria. PLoS Biol 3:238

    Article  Google Scholar 

  • Gauthier MG, Herrick J, Bechhoefer J (2010) Defects and DNA replication. Phys Rev Lett 104:218104

    Article  PubMed  Google Scholar 

  • Jiang Q, Karata K, Woodgate R, Cox MM, Goodman MF (2009) The active form of DNA polymerase V is UmuD’2C RecA* ATP. Nature 460:359–363

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kato T, Rothman RH, Clark AJ (1974) Analysis of the role of recombination and repair in mutagenesis of Escherichia coli by UV Irradiation. Genetics 87:1–18

    Google Scholar 

  • Krishna S, Maslov S, Sneppen K (2007) UV-induced mutagenesis in Escherichia coli SOS response: a quantitative model. PLoS Comput Biol 3(3):0451–0462

    Article  CAS  Google Scholar 

  • Kuzminov A (1999) Recombinational repair of DNA damage in Escherichia coli and bacteriophage λ. Microbiol Mol Biol Rev 63:751–813

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lin CG, Kovalsky O, Grossman L (1997) DNA damage-dependent recruitment of nucleotide excision repair and transcription proteins to Escherichia coli inner membranes. Nucleic Acids Res 25(15):3151–3158

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ni M, Wang SY, Li JK, Ouyang Q (2007) Simulating the temporal modulation of inducible DNA damage response in Escherichia coli. Biophys J 93:62–73

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Radman M (1975) SOS repair hypothesis: phenomenology of an inducible DNA repair which is accompanied by mutagenesis. In: Hanawalt P, Setlow R (eds) Molecular mechanisms for repair of DNA, Part A. Plenum Press, pp 355–367

    Google Scholar 

  • Rupert CS (1975) Enzymatic photoreactivation: overview. In: Hanawalt P, Setlow R (eds) Molecular mechanisms for repair of DNA, Part A. Plenum Press, pp 7387

    Google Scholar 

  • Rupp WD, Howard-Flanders P (1968) Discontinuities in the DNA synthesized in an excision-defective strain of Escherichia coli following ultraviolet irradiation. J Mol Biol 31:291–304

    Article  CAS  PubMed  Google Scholar 

  • Tang M, Ross M (1985) Single-strand breakage of DNA in UV-Irradiated uvrA, uvrB, and uvrC mutants of Escherichia coli. J Bacteriol 161:933–938

    CAS  PubMed  PubMed Central  Google Scholar 

  • Tang M, Shen X, Frank EG, O’Donnell M, Woodgate R, Goodman MF (1999) UmuD’2C is an error-prone DNA polymerase, Escherichia coli Pol V. Proc Natl Acad Sci 96:8919–8924

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Van Houten B (1990) Nucleotide excision repair in Escherichia coli. Microbiol Rev 54:18–51

    PubMed  PubMed Central  Google Scholar 

  • Wang Z (2001) Translesion synthesis by the UmuC family of DNA polymerase. Mutat Res 486:59

    Article  CAS  PubMed  Google Scholar 

  • Weigle JJ (1953) Induction of mutation in bacterial virus. Proc Natl Acad Sci 39:628–636

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Witkin EM (1976) Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. Bacteriol Rev 40:869

    CAS  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Laboratory of Radiation Biology, Joint Institute for Nuclear Research, Dubna, Russia

    Aleksandr Bugay, Maria Vasilyeva, Aleksandr Parkhomenko & Evgeny Krasavin

Authors
  1. Aleksandr Bugay
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  2. Maria Vasilyeva
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  3. Aleksandr Parkhomenko
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  4. Evgeny Krasavin
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Corresponding author

Correspondence to Aleksandr Bugay .

Editor information

Editors and Affiliations

  1. Joint Institute for Nuclear Research, Dubna, Moscow Region, Russia

    Victoria L. Korogodina

  2. Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada

    Carmel E Mothersill

  3. Genetics and Biotechnology, St. Petersburg State University, St. Petersburg, Russia

    Sergey G. Inge-Vechtomov

  4. Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada

    Colin B. Seymour

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Bugay, A., Vasilyeva, M., Parkhomenko, A., Krasavin, E. (2016). Mathematical Analysis of Regulatory Networks and Damage Repair Efficiency in Bacterial Cells. In: Korogodina, V., Mothersill, C., Inge-Vechtomov, S., Seymour, C. (eds) Genetics, Evolution and Radiation. Springer, Cham. https://doi.org/10.1007/978-3-319-48838-7_15

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