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BMPs in Dental Medicine: Promises and Challenges

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Bone Morphogenetic Proteins: Systems Biology Regulators

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Regeneration of bone is critical to the rehabilitation of congenital malformations and defects resulting from trauma or tumor resection in the craniofacial skeleton, as well as defects resulting from periodontal disease or remodeling following tooth extractions. It is the objective of this text to reflect pioneering and significant preclinical and clinical observations, promises, and challenges, of bone morphogenetic proteins (BMPs) with focus on recombinant human BMP-2 (rhBMP-2) but also recombinant human BMP-7 (rhBMP-7) and recombinant human growth/differentiation factor-5 (rhGDF-5) in craniofacial settings to include alveolar bone augmentation for implant dentistry.

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Acknowledgments

Earlier versions of this text have been published for reviews in journals and book chapters. The text is continuously subject to revisions and updating as new information becomes available in our laboratory. Studies elaborated herein conducted in our laboratories were supported by W.L. Gore & Associates, Genetics Institute, Wyeth Research, Medtronic, Daewoong Pharmaceuticals, and Nobel Biocare.

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  1. Laboratory for Applied Periodontal and Craniofacial Regeneration – The Dental College of Georgia, Augusta University, 1430 John Wesley Gilbert Drive, Augusta, 30912, GA, United States

    Ulf M. E. Wikesjö DDS, DMD, Dr Odont & Cristiano Susin DDS, MSD, Dr Odont

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  1. Ulf M. E. Wikesjö DDS, DMD, Dr Odont
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  2. Cristiano Susin DDS, MSD, Dr Odont
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Correspondence to Ulf M. E. Wikesjö DDS, DMD, Dr Odont .

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  1. School of Medicine, University of Zagreb, Zagreb, Croatia

    Slobodan Vukicevic

  2. perForm Biologics Inc, Holliston, Massachusetts, USA

    Kuber T. Sampath

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Wikesjö, U.M.E., Susin, C. (2017). BMPs in Dental Medicine: Promises and Challenges. In: Vukicevic, S., Sampath, K. (eds) Bone Morphogenetic Proteins: Systems Biology Regulators. Progress in Inflammation Research. Springer, Cham. https://doi.org/10.1007/978-3-319-47507-3_11

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