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Indications for Tyrosine Kinase Inhibitors in the Treatment of Solid Tumors

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Resistance to Tyrosine Kinase Inhibitors

Part of the book series: Resistance to Targeted Anti-Cancer Therapeutics ((RTACT))

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Abstract

Tyrosine kinase inhibitors (TKIs) constitute an important element in the treatment of solid tumors. Their use is expanding in the last years since clinical trials showed survival benefit, setting new treatment indications. Moreover, new molecules are being developed targeting resistance mechanisms such as acquired mutations or feedback mechanisms of the upregulated signaling pathway. The available TKIs and their indications of use through clinical trials are listed and discussed.

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Abbreviations

ALK:

Anaplastic lymphoma kinase

EGFR:

Epidermal growth factor receptor

FGFR:

Fibroblast growth factor receptor

GIST:

Gastrointestinal stromal tumor

HER2:

Human epidermal growth factor receptor 2

NSCLC:

Non-small-cell lung cancer

OS:

Overall survival

PDGFRA:

Platelet-derived growth factor receptor alpha

PFS:

progression free survival

TKI:

Tyrosine kinase inhibitor

VEGFR:

Vascular endothelial growth factor vs. versus

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Author information

Authors and Affiliations

  1. Department of Haematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charitè Medical University, Berlin, Germany

    Maria Vergoulidou

Authors
  1. Maria Vergoulidou
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Correspondence to Maria Vergoulidou .

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Editors and Affiliations

  1. Pisa University Hospital, Pisa, Italy

    Daniele Focosi

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Vergoulidou, M. (2016). Indications for Tyrosine Kinase Inhibitors in the Treatment of Solid Tumors. In: Focosi, D. (eds) Resistance to Tyrosine Kinase Inhibitors. Resistance to Targeted Anti-Cancer Therapeutics. Springer, Cham. https://doi.org/10.1007/978-3-319-46091-8_7

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