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Convergence of Osteoimmunology and Immunomodulation for the Development and Assessment of Bone Biomaterials

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The Immune Response to Implanted Materials and Devices

Abstract

The traditional biological principle for the development of bone biomaterials is to directly induce osteogenic differentiation of osteoblastic lineage cells. With this principle, most of the efforts are spent on optimizing the biomechanical and physicochemical properties of biomaterials to enhance osteogenic differentiation of mesenchymal stem cells. Given the vital roles of immune cells in bone dynamics, we propose a new concept “osteoimmunomodulation” in recognition of the importance of immune response during biomaterial-mediated osteogenesis. The paradigm of bone biomaterials design is also suggested to shift to an osteoimmunomodulatory material, and the possible evaluation strategies for the osteoimmunomodulation property of bone biomaterials are summarized. It is expected that bone biomaterials with favorable osteoimmunomodulation properties will be more clinically relevant to control new bone formation and biomaterial degradation in a controllable and biologically suitable manner.

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Acknowledgements

The authors would like to acknowledge the Q-CAS Biotechnology Fund (GJHZ1505), the Prince Charles Hospital Foundation, QUT Funding for Australia-China Centre of Tissue Engineering and Regenerative Medicine (ACCTERM), Recruitment Program of Global Young Talent, China (C.W.), the National High Technology Research and Development Program of China (863 Program, SS2015AA020302), Natural Science Foundation of China (Grant 31370963), Program of Shanghai Outstanding Academic Leaders (15XD1503900), Key Research Program of Chinese Academy of Sciences (Grant KGZDEW-T06), Innovative Project of SIC, CAS, and ARC (DP120103697). We thank Dr Thor Friis who proofread the draft of the manuscript.

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Authors and Affiliations

  1. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, 4059, Australia

    Zetao Chen & Yin Xiao

  2. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Chinese Academy of Sciences, Shanghai Institute of Ceramics, Shanghai, China

    Zetao Chen & Yin Xiao

  3. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China

    Chengtie Wu

  4. The Australia–China Centre for Tissue Engineering and Regenerative Medicine, Queensland University of Technology, Brisbane, QLD, Australia

    Chengtie Wu

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  1. Zetao Chen
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Correspondence to Yin Xiao .

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  1. Department of Life and Environmental Sciences, Marche Polytechnic University, Ancona, Italy

    Bruna Corradetti

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Chen, Z., Wu, C., Xiao, Y. (2017). Convergence of Osteoimmunology and Immunomodulation for the Development and Assessment of Bone Biomaterials. In: Corradetti, B. (eds) The Immune Response to Implanted Materials and Devices. Springer, Cham. https://doi.org/10.1007/978-3-319-45433-7_6

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