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Remote Ischemic Conditioning: A Highly Translatable Therapy for Acute Stroke

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Neuroprotective Therapy for Stroke and Ischemic Disease

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

Ischemic preconditioning is the most potent protectant against ischemic injury. Remote ischemic conditioning (RIC), a further development of ischemic preconditioning, is safe, feasible, and highly translational and represents one of the most promising strategies for neuroprotection and vasculoprotection during acute ischemic stroke. RIC grew out of the field of cardioprotection but there is now strong preclinical evidence and emerging clinical evidence of its activity and efficacy in acute ischemic stroke. While the mechanisms of protection are not completely known, RIC triggers endogenous protective mechanism and increases cerebral blood flow. RIC is ideal as a prehospital therapy and has potential as an adjunctive therapy to mechanical thrombectomy. Its ease of use makes RIC an attractive therapy to be used in community hospitals and during helicopter transport.

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Authors and Affiliations

  1. Department of Neurology, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA, 30912, USA

    Chizoba J. Ezepue M.D. & David C. Hess M.D.

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  1. Chizoba J. Ezepue M.D.
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  2. David C. Hess M.D.
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Correspondence to David C. Hess M.D. .

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  1. Department of Neurology and Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA

    Paul A. Lapchak

  2. Loma Linda University School of Medicine, Loma Linda, California, USA

    John H. Zhang

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Ezepue, C.J., Hess, D.C. (2017). Remote Ischemic Conditioning: A Highly Translatable Therapy for Acute Stroke. In: Lapchak, P., Zhang, J. (eds) Neuroprotective Therapy for Stroke and Ischemic Disease. Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-319-45345-3_18

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