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Comparative Analysis of Islet Development

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Pancreatic Islet Biology

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

The pancreatic islet plays a critical role in glucose homeostasis. The islet is a highly vascularized micro-organ embedded in the exocrine pancreas, which mainly consists of endocrine hormone-secreting cells: beta cells (insulin), alpha cells (glucagon), delta cells (somatostatin), pancreatic polypeptide (PP) cells, and epsilon cells (ghrelin). In this chapter, we review fetal endocrine pancreatic cell development in various species, providing a glimpse of the evolutionary changes followed by a molecular hierarchy of genes involved in pancreas development and a model of islet formation that recent technological advances have made possible. Considering current concerns, species differences between humans and rodents will be discussed in detail.

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Authors and Affiliations

  1. Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, MC1027, Chicago, IL, USA

    Ananta Poudel & Manami Hara

  2. Departments Surgery, The University of Chicago, 5841 South Maryland Avenue, MC1027, Chicago, IL, USA

    Omid Savari & Zehra Tekin

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  1. Ananta Poudel
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  2. Omid Savari
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  3. Zehra Tekin
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  4. Manami Hara
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Correspondence to Manami Hara .

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Editors and Affiliations

  1. NHMRC Clinical Trials Centre Diabetes and Islet-biology Group, The University of Sydney Faculty of Medicine, Sydney, New South Wales, Australia

    Anandwardhan A. Hardikar

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Poudel, A., Savari, O., Tekin, Z., Hara, M. (2016). Comparative Analysis of Islet Development. In: A. Hardikar, A. (eds) Pancreatic Islet Biology. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-45307-1_2

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