Skip to main content

Nonisotopic Thyroid Imaging

  • Reference work entry
  • First Online:
Thyroid Diseases

Part of the book series: Endocrinology ((ENDOCR))

  • 1842 Accesses

Abstract

Thyroid ultrasonography (US) is a reliable diagnostic tool for the evaluation of focal and diffuse thyroid disease. US accurately identifies the size and location of thyroid nodules and defines their risk of malignancy. Irregular margins, microcalcifications, taller-than-wide shape, deep hypoechogenicity and extrathyroid extension are clear-cut signs of malignancy while the predictive role of color-doppler and elastography findings is still controversial. The use of the recently proposed US classifications systems decreases the possible inconsistency of US descriptive reports, provides a reproducible tool to select lesions that should undergo aspiration biopsy, and improves the communication between sonographers, clinicians and pathologists. Additionally, US examination may suggest an altered thyroid function or an inflammatory condition or confirm size abnormalities and changes of thyroid structure.

The expensive cross-sectional imaging techniques (computed tomography or magnetic resonance imaging) are less sensitive and specific tools for the diagnosis of thyroid diseases. These imaging modalities should be used in the presurgical staging of thyroid malignancies at risk of extra-thyroidal spread to demonstrate the involvement of cervical structures and planning the extension of surgery. Their use in the postsurgical surveillance of cervical cancer recurrences appears limited and is indicated mainly in patients with increasing thyroglobulin (or calcitonin) levels and inconclusive neck US.

The role of functional imaging methods (thyroid scintiscan and PET/CT) is addressed in the dedicated section of this text.

Disclosure of Interests

The authors have no financial interest to declare.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 329.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 449.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Ahuja AT, Ying M. Sonographic evaluation of cervical lymph nodes. Am J Roentgenol. 2005;184:1691–9.

    Article  Google Scholar 

  • Ahuja A, Chick W, King W, Metreweli C. Clinical significance of the comet-tail artifact in thyroid ultrasound. J Clin Ultrasound. 1996;24:129–33.

    Article  PubMed  CAS  Google Scholar 

  • Ahuja AT, Ying M, Yuen HY, Metreweli C. ‘Pseudocystic’ appearance of non-Hodgkin’s lymphomatous nodes: an infrequent finding with high-resolution transducers. Clin Radiol. 2001;56:111–5.

    Article  PubMed  CAS  Google Scholar 

  • Aiken AH. Imaging of thyroid cancer. Semin Ultrasound CT MR. 2012;33:138–49.

    Article  PubMed  Google Scholar 

  • Alexander EK, Hurwitz S, Heering JP, et al. Natural history of benign solid and cystic nodules. Ann Intern Med. 2003;138:315–8.

    Article  PubMed  Google Scholar 

  • American Institute of Ultrasound in Medicine, American College of Radiology, Society for Pediatric Radiology, Society of Radiologists in Ultrasound. AIUM practice guideline for the performance of a thyroid and parathyroid ultrasound examination. J Ultrasound Med. 2013;32:1319–29.

    Article  Google Scholar 

  • Anderson L, Middleton WD, Teefey SA, et al. Hashimoto thyroiditis: part 1. Sonographic analysis of the nodular form of Hashimoto thyroiditis. Am J Roentgenol. 2010a;195:208–15.

    Article  Google Scholar 

  • Anderson L, Middleton WD, Teefey SA, et al. Hashimoto thyroiditis: part 2. Sonographic analysis of benign and malignant nodules in patients with diffuse Hashimoto thyroiditis. Am J Roentgenol. 2010b;195:216–9.

    Article  Google Scholar 

  • Arun C, Nachiappan AC, Metwalli ZA, et al. The thyroid: review of imaging features and biopsy techniques with radiologic-pathologic correlation. Radiographics. 2014;34:276–93.

    Article  Google Scholar 

  • Azizi G, Keller J, Lewis M, Puett D, Rivenbark K, Malchoff C. Performance of elastography for the evaluation of thyroid nodules: a prospective study. Thyroid. 2013;23:734–40.

    Article  PubMed  Google Scholar 

  • Bahn RS, Castro MR. Approach to the patient with nontoxic multinodular goiter. J Clin Endocrinol Metab. 2011;96:1202–12.

    Article  PubMed  CAS  Google Scholar 

  • Baskin HJ. Anatomy and anomalies. In: Baskin HJ, Duick DS, Levine RA, editors. Thyroid ultrasound and ultrasound-guided FNA. 2nd ed. New-York: Springer; 2008. p. 45–6.

    Chapter  Google Scholar 

  • Beland MD, Kwon L, Delellis RA, Cronan JJ, Grant EG. Nonshadowing echogenic foci in thyroid nodules: are certain appearances enough to avoid thyroid biopsy? J Ultrasound Med. 2011;30:753–60.

    Article  PubMed  Google Scholar 

  • Bennedbaek FN, Hegedüs L. The value of ultrasonography in the diagnosis and follow-up of subacute thyroiditis. Thyroid. 1997;7:45–50.

    Article  PubMed  CAS  Google Scholar 

  • Binder RE, Pugatch RD, Faling LJ, Kanter RA, Sawin CT. Diagnosis of posterior mediastinal goiter by computed tomography. J Comput Assist Tomogr. 1980;4:550–2.

    Article  PubMed  CAS  Google Scholar 

  • Bonnema SJ, Hegedüs L. Radioiodine therapy in benign thyroid diseases: effects, side effects, and factors affecting therapeutic outcome. Endocr Rev. 2012;33:920–80.

    Article  PubMed  CAS  Google Scholar 

  • Brauer VFH, Miehle K, Wiesner TD, et al. Interobserver variation for ultrasound determination of thyroid nodule volumes. Thyroid. 2005;15:1169–75.

    Article  PubMed  CAS  Google Scholar 

  • Campanella P, Ianni F, Rota CA, Corsello SM, Pontecorvi A. Quantification of cancer risk of each clinical and ultrasonographic suspicious feature of thyroid nodules: a systematic review and meta-analysis. Eur J Endocrinol. 2014;170:203–11.

    Article  CAS  Google Scholar 

  • Carty SE, Cooper DS, Doherty GM, et al. Consensus statement on the terminology and classification of central neck dissection for thyroid cancer. Thyroid. 2009;19:1153–8.

    Article  PubMed  Google Scholar 

  • Chammas MC, de Araujo Filho VJ, Moysés RA, et al. Predictive value for malignancy in the finding of microcalcifications on ultrasonography of thyroid nodules. Head Neck. 2008;30:1206–61.

    Article  PubMed  Google Scholar 

  • Chan BK, Desser TS, McDougall IR, et al. Common and uncommon sonographic features of papillary thyroid carcinoma. J Ultrasound Med. 2003;22:1083–90.

    Article  PubMed  Google Scholar 

  • Chaudhary V, Bano S. Thyroid ultrasound. Indian J Endocrinol Metab. 2013;17:219–27.

    Article  PubMed  PubMed Central  Google Scholar 

  • Choi JS, Kim J, Kwak JY, et al. Preoperative staging of papillary thyroid carcinoma: comparison of ultrasound imaging and CT. Am J Roentgenol. 2009a;193:871–8.

    Article  Google Scholar 

  • Choi EC, Moon WJ, Lim YC. Case report. Tuberculous cervical lymphadenitis mimicking metastatic lymph nodes from papillary thyroid carcinoma. Br J Radiol. 2009b;82:208–11.

    Article  Google Scholar 

  • Choi SH, Kim E-K, Kwak JY, Kim MJ, Son EJ. Interobserver and intraobserver variations in ultrasound assessment of thyroid nodules. Thyroid. 2010;20:167–72.

    Article  PubMed  Google Scholar 

  • Cooper JC, Nakielny R, Talbot CH. The use of CT in the evaluation of large multinodular goiter. Ann R Coll Surg Engl. 1991;73:32–5.

    PubMed  PubMed Central  CAS  Google Scholar 

  • D’Orsi CJ, Sickles EA, Mendelson EB, et al. BI-RADS® Atlas, breast imaging reporting and data system. 4th ed. Reston: American College of Radiology; 2003.

    Google Scholar 

  • Davies L, Welch HG. Increasing incidence of thyroid cancer in the United States. JAMA. 2006;295:2164–7.

    Article  PubMed  CAS  Google Scholar 

  • Davies L, Welch HG. Current thyroid cancer trends in the United States. JAMA Otolaryngol Head Neck Surg. 2014;140:317–22.

    Article  PubMed  Google Scholar 

  • Davies L, Pichiotino E, Black WC, Tosteson AN. Developing a registry for thyroid incidentalomas: lessons learned and the path forward. Thyroid. 2016;26:650–6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Durante C, Costante G, Lucisano G, et al. The natural history of benign thyroid nodules. JAMA. 2015;313:926–35.

    Article  PubMed  CAS  Google Scholar 

  • Frasoldati A, Valcavi R. Challenges in neck ultrasonography: lymphadenopathy and parathyroid glands. Endocr Pract. 2004;10:261–8.

    Article  PubMed  Google Scholar 

  • Frasoldati A, Pacella CM, Papini E, Hegedüs L. In: Wartoksky L, Van Nostrand D, editors. Thyroid cancer: a comprehensive guide to clinical management. 3rd ed. New York: Springer; 2016.

    Google Scholar 

  • Ghajarzadeh M, Sodagari F, Shakiba M. Diagnostic accuracy of sonoelastography in detecting malignant thyroid nodules: a systematic review and meta-analysis. Am J Roentgenol. 2014;202:379–89.

    Article  Google Scholar 

  • Gharib H, Papini E, Garber JR, et al. American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinology Guidelines for clinical practice for the diagnosis and management of thyroid nodules – 2016 Update. Endocr Pract. 2016;22:622–39.

    Article  PubMed  Google Scholar 

  • Giovannella L, Ceriani L, Treglia G. Role of isotope scan, including PET/CT, in nodular goitre. Best Pract Res Clin Endocrinol Metab. 2014;28:507–18.

    Article  Google Scholar 

  • Guglielmi R, Pacella CM, Bianchini A, et al. Percutaneous ethanol injection treatment in benign thyroid lesions: role and efficacy. Thyroid. 2004;14:125–31.

    Article  PubMed  CAS  Google Scholar 

  • Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26:1–133.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hegedüs L. Down-sizing the overzealous search for low-risk thyroid malignancy. Endocrine. 2016;52:408–10.

    Article  PubMed  CAS  Google Scholar 

  • Hegedüs L, Paschke R, Krohn K, Bonnema SJ. MultinodularGoiter. In: Jameson JL, De Groot LJ, editors. Endocrinology: adult and pediatric. 7th ed. Philadelphia: Elsevier; 2016. p. 1570–83.

    Chapter  Google Scholar 

  • Hoang JK, Lee WK, Lee M, Johnson D, Farrell S. US features of thyroid malignancy: pearls and pitfalls. Radiographics. 2007;27:847–60.

    Article  PubMed  Google Scholar 

  • Horvath E, Majlis S, Rossi R, et al. An ultrasonogram reporting system for thyroid nodules stratifying cancer risk for clinical management. J Clin Endocrinol Metab. 2009;94:1748–51.

    Article  PubMed  CAS  Google Scholar 

  • Ito Y, Miyauchi A. Nonoperative management of low-risk differentiated thyroid carcinoma. Curr Opin Oncol. 2015;27:15–20.

    Article  PubMed  Google Scholar 

  • Jeh SK, Jung SL, Kim BS, Lee YS. Evaluating the degree of conformity of papillary carcinoma and follicular carcinoma to the reported ultrasonographic findings of malignant thyroid tumor. Korean J Radiol. 2007;8:192–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Jin J, McHenry CR. Thyroid incidentaloma. Best Pract Res Clin Endocrinol Metab. 2012;26:83–96.

    Article  PubMed  Google Scholar 

  • Kessler A, Rappaport Y, Blank A, et al. Cystic appearance of cervical lymph nodes is characteristic of metastatic papillary thyroid carcinoma. J Clin Ultrasound. 2003;31:21–5.

    Article  PubMed  Google Scholar 

  • Khoo MLC, Asa SL, Witterick IJ, Freeman JL. Thyroid calcification and its association with thyroid carcinoma. Head Neck. 2002;24:651–5.

    Article  PubMed  Google Scholar 

  • Kim EK, Park CS, Chung WY, et al. New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid. Am J Roentgenol. 2002;178:687–91.

    Article  Google Scholar 

  • Kim BM, Kim MJ, Kim EK, et al. Sonographic differentiation of thyroid nodules with eggshell calcifications. J Ultrasound Med. 2008;27:1425–30.

    Article  PubMed  Google Scholar 

  • King AD. Imaging for staging and management of thyroid cancer. Cancer Imaging. 2008;8:57–69.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kobayashi K, Fukata S, Miyauchi A. Diagnosis of follicular carcinoma of the thyroid: role of sonography in preoperative diagnosis of follicular nodules. J Med Ultrasonics. 2005;32:153–8.

    Article  Google Scholar 

  • Kovács GL, Gonda G, Vadász G, Ludmány E, Uhrin K, Görömbey Z, Kovács L, Hubina E, Bodó M, Góth MI, Szabolcs I. Epidemiology of thyroid microcarcinoma found in autopsy series conducted in areas of different iodine intake. Thyroid. 2005;15(2):152–7.

    Article  PubMed  Google Scholar 

  • Kuna SK, Bracic I, Tesic V, et al. Ultrasonographic differentiation of benign from malignant neck lymphadenopathy in thyroid cancer. J Ultrasound Med. 2006;25:1531–7.

    Article  PubMed  Google Scholar 

  • Kupferman ME, Patterson M, Mandel SJ, et al. Patterns of lateral neck metastasis in papillary thyroid carcinoma. Arch Otolaryngol Head Neck Surg. 2004;130:857–60.

    Article  PubMed  Google Scholar 

  • Landry CS, Grubbs EG, Busaidy NL, et al. Cystic lymph nodes in the lateral neck as indicators of metastatic papillary thyroid cancer. Endocr Pract. 2010;17:240–4.

    Article  Google Scholar 

  • Langer JE, Khan A, Nisenbaum HL, et al. Sonographic appearance of focal thyroiditis. AJR. 2001;176:751–4.

    Article  PubMed  CAS  Google Scholar 

  • Leboulleux S, Girard E, Rose M, et al. Ultrasound criteria of malignancy for cervical lymph nodes in patients followed up for differentiated thyroid cancer. J Clin Endocrinol Metab. 2007;92:3590–4.

    Article  PubMed  CAS  Google Scholar 

  • Lee SK, Rho BH. Follicular thyroid carcinoma with an eggshell calcification. J Ultrasound Med. 2009;28:801–6.

    Article  PubMed  Google Scholar 

  • Lee MJ, Kim EK, Kwak JY, Kim MJ. Partially cystic thyroid nodules on ultrasound: probability of malignancy and sonographic differentiation. Thyroid. 2009;19:341–6.

    Article  PubMed  Google Scholar 

  • Lee K, Kawata R, Nishikawa S, et al. Diagnostic criteria of ultrasonographic examination for lateral node metastasis of papillary thyroid carcinoma. Acta Otolaryngol. 2010;130:161–6.

    Article  PubMed  Google Scholar 

  • Leenhardt L, Grosclaude P, Chérié-Challine L. Increased incidence of thyroid carcinoma in France: a true epidemic or thyroid nodule management effects? Report from the French Thyroid Cancer Committee. Thyroid. 2004;14:1056–60.

    Article  PubMed  Google Scholar 

  • Leenhardt L, Tranquart F, Tramalloni J. In: Carpi A, Mechanick JI, editors. Thyroid cancer. Boca Raton: CRC Press; 2011. p. 99–116.

    Chapter  Google Scholar 

  • Leenhardt L, Erdogan MF, Hegedus L, et al. European Thyroid Association guidelines for cervical ultrasound scan and ultrasound-guided techniques in the postoperative management of patients with thyroid cancer. Eur Thyroid J. 2013;2:147–59.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Levine RA. Thyroid ultrasound physics. In: Baskin HJ, Duick DS, Levine RA, editors. Thyroid ultrasound and ultrasound-guided FNA. New York: Springer; 2008. p. 9–26.

    Chapter  Google Scholar 

  • Lew JI, Solorzano CC. Use of ultrasound in the management of thyroid cancer. Oncologist. 2010;15:253–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu BJ, Xu HX, Zhang YF, Xu JM, Li DD, Bo XW, et al. Acoustic radiation force impulse elastography for differentiation of benign and malignant thyroid nodules with concurrent Hashimoto’s thyroiditis. Med Oncol. 2015;32:50.

    Article  PubMed  CAS  Google Scholar 

  • Lupo M, Levine RA. Ultrasound tissue enlargement: thyroiditis. In: Baskin HJ, Duick DS, Levine RA, editors. Thyroid ultrasound and ultrasound-guided FNA. 3rd ed. New York: Springer; 2014. p. 63–76.

    Google Scholar 

  • Machens A, Hinze R, Thomusch O, et al. Pattern of nodal metastasis for primary and preoperative thyroid cancer. World J Surg. 2002;26:22–8.

    Article  PubMed  Google Scholar 

  • Mandel SJ. Diagnostic use of ultrasonography in patients with nodular thyroid disease. Endocr Pract. 2004;10:246–52.

    Article  PubMed  Google Scholar 

  • McHenry CR, Huh ES, Machekano RN. Is nodule size an independent predictor of malignancy? Surgery. 2008;144:1062–9.

    Article  PubMed  Google Scholar 

  • McQueen AS, Bathia KSS. Thyroid nodule ultrasound: technical advances and future horizons. Insights Imaging. 2015;6:173–88.

    Article  PubMed  PubMed Central  Google Scholar 

  • Moon WJ, Jung SL, Lee JH, et al. Benign and malignant thyroid nodules: US differentiation – multicenter retrospective study. Radiology. 2008;247:762–70.

    Article  PubMed  Google Scholar 

  • Moon HJ, Kim EK, Kim MJ, Kwak JY. Lymphocytic thyroiditis on fine-needle aspiration biopsy of focal thyroid nodules: approach to management. Am J Roentgenol. 2009;193:345–9.

    Article  Google Scholar 

  • Moon HJ, Kwak JY, Kim MJ, Son EJ, Kim EK. Can vascularity at power Doppler US help predict thyroid malignancy? Radiology. 2010;255:260–9.

    Article  PubMed  Google Scholar 

  • Moon WJ, Baek JH, Jung SL, Kim DW, Kim EK, Kim JY, Korean Society of Thyroid Radiology (KSThR), Korean Society of Radiology, et al. Korean Society of Radiology Ultrasonography and the ultrasound-based management of thyroid nodules: consensus statement and recommendations. Korean J Radiol. 2011;12:1–14.

    Article  PubMed  PubMed Central  Google Scholar 

  • Nam SY, Shin JH, Ko EY, Hahn SY. A comparison of lymphocytic thyroiditis with papillary thyroid carcinoma showing suspicious ultrasonographic findings in a background of heterogeneous parenchyma. Ultrasonography. 2015;34:45–50.

    Article  PubMed  Google Scholar 

  • Noda Y, et al. MRI of the thyroid for differential diagnosis of benign thyroid nodules and papillary carcinomas. Am J Roentgenol. 2015;204:332–5.

    Article  Google Scholar 

  • Papini E, Guglielmi R, Bianchini A, et al. Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features. J Clin Endocrinol Metab. 2002;87:1941–6.

    Article  PubMed  CAS  Google Scholar 

  • Papini E, Pacella CM, Hegedus L. Thyroid ultrasound and ultrasound-assisted procedures: from shadows into an array of applications. Eur J Endocrinol. 2014;170:133–44.

    Article  CAS  Google Scholar 

  • Papini E, Pacella CM, Frasoldati A, Hegedus L. Ultrasonic imaging of the thyroid gland. In: Wartofski L, Van Nostrand D, editors. Thyroid cancer. A comprehensive guide to clinical management. 3rd ed. New York: Springer; 2016.

    Google Scholar 

  • Park JS, Son KR, Na DG, et al. Performance of preoperative sonographic staging of papillary thyroid carcinoma based on the sixth edition of the AJCC/UICC TNM classification system. Am J Roentgenol. 2009;192:66–72.

    Article  Google Scholar 

  • Park CS, Kim SH, Jung SL, et al. Observer variability in the sonographic evaluation of thyroid nodules. J Clin Ultrasound. 2010;38:287–93.

    PubMed  Google Scholar 

  • Park AY, Son EJ, Han K, Youk JH, Kim JA, Park CS. Shear wave elastography of thyroid nodules for the prediction of malignancy in a large scale study. Eur J Radiol. 2015;84:407–12.

    Article  PubMed  Google Scholar 

  • Park HS, Chung EJ, Park MW, et al. Usefulness of radiologic examinations for diagnosing level VI lymph node metastasis in patients with laryngohypopharyngeal carcinoma. Eur Arch Otorhinolaryngol. 2016;273:3959: Epub ahead of print.

    Article  PubMed  Google Scholar 

  • Pedersen OM, Aardal NP, Larssen TB, Varhaug JE, Myking O, Vik-Mo H. The value of ultrasonography in predicting autoimmune thyroid disease. Thyroid. 2000;10:251–9.

    Article  PubMed  CAS  Google Scholar 

  • Perros P, Boelaert K, Colley S, et al. British Thyroid Association Guidelines for the management of thyroid cancer. Clin Endocrinol (Oxf). 2014;81 Suppl 1:1–122.

    Article  CAS  Google Scholar 

  • Raber W, Gessl A, Nowotny P, Vierhapper H. Thyroid ultrasound versus antithyroid peroxidase antibody determination: a cohort study of four hundred fifty-one subjects. Thyroid. 2002;12:725–31.

    Article  PubMed  Google Scholar 

  • Rago T, Vitti P. Diagnostic role of ultrasound and elastosonography in nodular goiter. Best Pract Res Clin Endocrinol Metab. 2014;28:519–29.

    Article  PubMed  Google Scholar 

  • Rago T, Chiovato L, Grasso L, Pinchera A, Vitti P. Thyroid ultrasound as a tool for detecting thyroid autoimmune disease and predicting thyroid dysfunction in apparently healthy subjects. J Endocrinol Invest. 2001;24:763–9.

    Article  PubMed  CAS  Google Scholar 

  • Rago T, Santini F, Scutari M, Pinchera A, Vitti P. Elastography: new developments in ultrasound for predicting malignancy in thyroid nodules. J Clin Endocrinol Metab. 2007;92:2917–22.

    Article  PubMed  CAS  Google Scholar 

  • Ralls PW, Mayekawa DS, Lee KP, et al. Color-flow Doppler sonography in Graves disease: “thyroid inferno”. Am J Roentgenol. 1988;150:781–4.

    Article  CAS  Google Scholar 

  • Randolph G, Sacks B, Baskin HJ. Ultrasound and mapping of the neck lymph nodes. In: Baskin HJ, Duick DS, Levine RA, editors. Thyroid ultrasound and ultrasound-guided FNA. 3rd ed. New York: Springer; 2013. p. 149–77.

    Chapter  Google Scholar 

  • Reading CC, Charboneau JW, Sebo TJ. Sonography of thyroid nodules: a classic pattern diagnostic approach. Ultrasound Q. 2005;21:157–65.

    Article  PubMed  Google Scholar 

  • Robbins KT, Shaha AR, Medina JE, et al. Consensus statement on the classification and terminology of neck dissection: committee for neck dissection classification, American Head and Neck Society. Arch Otolaryngol Head Neck Surg. 2008;134:536–8.

    Article  PubMed  Google Scholar 

  • Roh JL, Kim JM, Park C. Lateral cervical lymph node metastases from papillary thyroid carcinoma: pattern of nodal metastases and optimal strategy for neck dissection. Ann Surg Oncol. 2008;15:1177–82.

    Article  PubMed  Google Scholar 

  • Rosário PW, Bessa B, Valadão MM, Purisch S. Natural history of mild subclinical hypothyroidism: prognostic value of ultrasound. Thyroid. 2009;19:9–12.

    Article  PubMed  CAS  Google Scholar 

  • Russ G, Royer B, Bigorgne C, Rouxel A, Bienvenu-Perrard M, Leenhardt L. Prospective evaluation of thyroid imaging reporting and data system on 4550 nodules with and without elastography. Eur J Endocrinol. 2013;168:649–55.

    Article  PubMed  CAS  Google Scholar 

  • Seo YL, Yoon DJ, Lim KJ, et al. Locally advanced thyroid cancer: can CT help in prediction of extrathyroidal invasion to adjacent structures? Am J Roentgenol. 2010;195:240–4.

    Article  Google Scholar 

  • Sharma A, Jasim S, Reading CC, et al. Clinical presentation and diagnostic challenges of thyroid lymphoma: a cohort study. Thyroid. 2016;26:1061–7.

    Article  PubMed  Google Scholar 

  • Shin JH, Baek JH, Chung J, et al. Ultrasonography diagnosis and imaging-based management of thyroid nodules: revised Korean Society of thyroid radiology consensus statement and recommendations. Korean J Radiol. 2016;17:370–95.

    Article  PubMed  PubMed Central  Google Scholar 

  • Solbiati L, Osti V, Cova L, Tonolini M. Ultrasound of thyroid, parathyroid glands and neck lymph nodes. Eur Radiol. 2001;11:2411–24.

    Article  PubMed  CAS  Google Scholar 

  • Sorensen JR, Hegedus L, Kruse-Andersen S, Godballe C, Bonnema SJ. The impact of goiter and its treatment on the trachea, air-flow, oesophagus and swallowing. A systematic review. Best Pract Res Clin Endocrinol Metab. 2014;28:481–94.

    Article  PubMed  Google Scholar 

  • Sousa do Rosario PW, de Faria S, Bicalho L, et al. Ultrasonographic differentiation between metastatic and benign lymph nodes in patients with papillary thyroid carcinoma. J Ultrasound Med. 2005;24:1385–9.

    Article  Google Scholar 

  • Stack Jr BC, Ferris RL, Goldenberg D, et al. American Thyroid Association consensus review and statement regarding the anatomy, terminology, and rationale for lateral neck dissection in differentiated thyroid cancer. Thyroid. 2012;22:501–8.

    Article  PubMed  Google Scholar 

  • Taki S, Terahata S, Yamashita R, et al. Thyroid calcifications: sonographic patterns and incidence of cancer. Clin Imaging. 2004;28:368–71.

    Article  PubMed  Google Scholar 

  • Tam AA, Kaya C, Üçler R, Dirikoç A, Ersoy R, Çakır B. Correlation of normal thyroid ultrasonography with thyroid tests. Quat Imaging Med Surg. 2015;5:569–74.

    Google Scholar 

  • Tamsel S, Dermipolat G, Erdogan M, et al. Power Doppler US patterns of vascularity and spectral Doppler US parameters in predicting malignancy in thyroid nodules. Clin Radiol. 2007;62:245–51.

    Article  PubMed  CAS  Google Scholar 

  • Trimboli P, Guglielmi R, Monti S, et al. Ultrasound sensitivity for thyroid malignancy is increased by real-time elastography: a prospective multicenter study. J Clin Endocrinol Metab. 2012;97:4524–30.

    Article  PubMed  CAS  Google Scholar 

  • Verburg FA, Mader U, Luster M, Reiners C. Primary tumour diameter as a risk factor for advanced disease features of differentiated thyroid carcinoma. Clin Endocrinol (Oxf). 2009;71:291–7.

    Article  Google Scholar 

  • Wada N, Duh QY, Sugino K, et al. Lymph node metastasis from 259 papillary thyroid microcarcinomas: frequency, pattern of occurrence and recurrence, and optimal strategy for neck dissection. Ann Surg. 2003;237:399–407.

    PubMed  PubMed Central  Google Scholar 

  • Walfish PG. Thyroiditis. Curr Ther Endocrinol Metab. 1997;6:117–26.

    PubMed  CAS  Google Scholar 

  • Wang JC, Takashima S, Takajama F, et al. Tracheal invasion by thyroid carcinoma: prediction using RM imaging. Am J Roentgenol. 2001;177:929–36.

    Article  CAS  Google Scholar 

  • Wang JC, Takashima S, Matsushita T, et al. Esophageal invasion by thyroid carcinomas: prediction using MR imaging. J Comput Assist Tomogr. 2003;27:18–25.

    Article  PubMed  Google Scholar 

  • Wang N, Xu Y, Ge C, Guo R, Guo K. Association of sonographically detected calcification with thyroid carcinoma. Head Neck. 2006;28:1077–83.

    Article  PubMed  Google Scholar 

  • Wienke JR, et al. Sonographic features of benign thyroid nodules: interobserver reliability and overlap with malignancy. J Ultrasound Med. 2003;22:1027.

    Article  PubMed  Google Scholar 

  • Wu LM, Chen XX, Li YL, Hua J, Chen J, Hu J, Xu JR. On the utility of quantitative diffusion-weighted MR imaging as a tool in differentiation between malignant and benign thyroid nodules. Acad Radiol. 2014;21:355–63.

    Article  PubMed  Google Scholar 

  • Yamashiro I, de Cassio SO, Chammas MC, Cerri GG. Ultrasound findings in thyroiditis. Radiol Bras. 2007;40:75–9.

    Article  Google Scholar 

  • Yeh MW, Bauer AJ, Bernet VA, et al. American Thyroid Association statement on preoperative imaging for thyroid cancer surgery. Thyroid. 2015;25:3–14.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yoon DY, Lee JW, Chang SK, et al. Peripheral calcification in thyroid nodules: ultrasonographic features and prediction of malignancy. J Ultrasound Med. 2007;26:1349–55.

    Article  PubMed  Google Scholar 

  • Youan WH, Chiou HJ, Chou YH, et al. Gray-scale and color Doppler ultrasonographic manifestations of papillary thyroid carcinoma: analysis of 51 cases. Clin Imaging. 2006;30:394–401.

    Article  Google Scholar 

  • Yuan WH, Chiou HJ, Chou YH, et al. Gray-scale and color Doppler ultrasonographic manifestations of papillary thyroid carcinoma: analysis of 51 cases. Clin Imaging. 2006;30:394–401.

    Article  PubMed  Google Scholar 

  • Zhang YF, Liu C, Xu HX, et al. Acoustic radiation force impulse imaging: a new tool for the diagnosis of papillary thyroid microcarcinoma. Biomed Res Int. 2014;2014:41–69.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to E. Papini .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Papini, E., Guglielmi, R., Bizzarri, G., Frasoldati, A. (2018). Nonisotopic Thyroid Imaging. In: Vitti, P., Hegedüs, L. (eds) Thyroid Diseases. Endocrinology. Springer, Cham. https://doi.org/10.1007/978-3-319-45013-1_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-45013-1_4

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-45012-4

  • Online ISBN: 978-3-319-45013-1

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics