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Cardiac Xenotransplantation

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Congestive Heart Failure and Cardiac Transplantation

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Abstract

The scarcity of human donor hearts limits cardiac transplantation to a small fraction of potential recipients. This scarcity will probably increase during the next several decades. While mechanical and bioengineered hearts might, in principle, supplant cardiac transplantation, the related cost and technical sophistication required may limit their use. Using hearts from animals (called xenotransplantation), especially from swine, could potentially address the scarcity of human hearts and the limitations of devices and bioengineered organs. However, the immune response of the recipient against the graft, and the potential for transferring zoonoses and physiologic incompatibilities, appears to pose barriers to clinical cardiac xenotransplantation today.

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Authors and Affiliations

  1. Surgery; Microbiology & Immunology, University of Michigan, 1150 W. Medical Center Drive, Ann Arbor, MI, 48109-5656, USA

    Jeffrey L. Platt MD & Marilia Cascalho MD, PhD

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  1. Jeffrey L. Platt MD
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  2. Marilia Cascalho MD, PhD
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Correspondence to Jeffrey L. Platt MD .

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  1. Lillehei Heart Institute, Department of Medicine, University of Minnesota Medical Center, University of Minnesota, Minneapolis, Minnesota, USA

    Daniel J. Garry

  2. Division of Cardiovascular Medicine, University of Minnesota, Minneapolis, Minnesota, USA

    Robert F. Wilson

  3. Division of Cardiovascular Medicine, University of Minnesota, Minneapolis, Minnesota, USA

    Zeev Vlodaver

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Platt, J.L., Cascalho, M. (2017). Cardiac Xenotransplantation. In: Garry, D., Wilson, R., Vlodaver, Z. (eds) Congestive Heart Failure and Cardiac Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-44577-9_34

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