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Hereditary Cardiac Conduction Diseases

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Clinical Cardiogenetics

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Abstract

Cardiac conduction diseases (CCD) are a group of electrical defects of the heart with multiple hereditary and non-hereditary etiologies. The clinical spectrum of CCD includes asymptomatic patients with incidental electrocardiographic abnormalities, as well as patients presenting with syncope and cardiac arrest. CCD can be associated with other hereditary syndromes including Brugada syndrome, cardiomyopathy and neuromuscular diseases. A comprehensive clinical evaluation of patients with CCD including a detailed family history as well as molecular diagnostics in select cases are key to establishing the correct etiology, guiding patient management and directing family screening. In this chapter, we discuss the differential diagnosis of CCD, guiding principles in cardiogenetic evaluation as well as specific genotype-phenotype correlations.

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Authors and Affiliations

  1. Department of Medicine, Cardiovascular Genetics Center, Montreal Heart Institute, Université de Montréal, Montréal, Canada

    Rafik Tadros MD PhD & Julia Cadrin-Tourigny MD MSc

  2. Department of Experimental and Clinical Cardiology, Academic Medical Center, Amsterdam, Netherlands

    Rafik Tadros MD PhD

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  1. Rafik Tadros MD PhD
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  2. Julia Cadrin-Tourigny MD MSc
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Correspondence to Rafik Tadros MD PhD .

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Editors and Affiliations

  1. Department of Cardiology, St. Elisabeth-TweeSteden Ziekenhuis, Tilburg, The Netherlands

    Hubert F. Baars

  2. Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands

    Pieter A. F. M. Doevendans

  3. Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands

    Arjan C. Houweling

  4. Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands

    J. Peter van Tintelen

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Tadros, R., Cadrin-Tourigny, J. (2016). Hereditary Cardiac Conduction Diseases. In: Baars, H., Doevendans, P., Houweling, A., van Tintelen, J. (eds) Clinical Cardiogenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-44203-7_16

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