Abstract
Perfusion refers to the delivery of oxygen, glucose and other nutrients to tissues by means of blood flow and its disruption is commonly reported in different pathologies. In particular, changes in brain perfusion is found in most brain diseases, ranging from stroke to neurodegenerative and neoplastic disorders. In this chapter the basic physics and physiological principles of Arterial Spin Labeling (ASL) brain perfusion measurement are discussed, together with research and clinical applications of this promising noninvasive technique.
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References
Petrella JR, Provenzale JM (2000) MR perfusion imaging of the brain: techniques and applications. AJR Am J Roentgenol 175:207–220
Cha S (2003) Perfusion MR imaging: basic principles and clinical applications. Magn Reson Imaging Clin N Am 11(3):403–413
Provenzale JM, Jahan R, Naidich TP, Fox AJ (2003) Assessment of the patient with hyperacute stroke: imaging and therapy. Radiology 229(2):347–359
Scarabino T, Nemore F, Giannatempo GM et al (2003) 3.0 T magnetic resonance in neuroradiology. Eur J Radiol 48:154–164
Scarabino T, Giannatempo GM, Pollice S et al (2004) 3.0 T perfusion MR imaging. Riv Neuroradiol 17:807–812
Shimony JS (2005) Concepts in perfusion MRI. Syllabus. Int Soc Magn Reson Med 13
Zaharchuk G (2005) Frontiers of cerebral perfusion magnetic resonance imaging. Appl Radiol (Suppl to January) (34):100–111
Manka C, Traber F, Gieseke J et al (2005) Three-dimensional dynamic susceptibility-weighted perfusion MR imaging at 3.0 T: feasibility and contrast agent dose. Radiology 234(3):869–877
Barbier EL, Lamalle L, Decorps M (2001) Methodology of brain perfusion imaging. J Magn Reson Imaging 13(4):496–520
Derdeyn CP, TO V, Yundt KD et al (2002) Variability of cerebral blood volume and oxygen extraction: stages of cerebral haemodynamic impairment revisited. Brain 125(3):595–607
Chen JJ, Wieckowska M, Meyer E, GB P (2008) Cerebral blood flow measurement using fMRI and PET: across-validation study. Int J Biomed Imaging 2008 :516359. doi:10.1155/2008/516359Article ID
Wintermark M, Sesay M, Barbier E et al (2005) Comparative overview of brain perfusion imaging techniques. Stroke 36:e83–e99
Penfield JG, Reilly RF Jr (2007) What nephrologists need to know about gadolinium. Nat Clin Pract Nephrol 3:654–668
Sadowski EA, Benne LK, Chan MR et al (2007) Nephrogenic systemic fibrosis: risk factors and incidence estimation. Radiology 243:148–157
Detre JA, Leigh JS, WIlliams DS, Koretsky AP (1992) Perfusion imaging. Magn Reson Med 23:37–45
Williams DS, Detre JA, Leigh JS, Koretsky AP (1992) Magnetic resonance imaging of perfusion using spin-inversion of arterial water. Proc Natl Acad Sci U S A 89:212–216
Golay X, Hendrikse J, Lim TC (2004) Perfusion imaging using arterial spin labeling. Top Magn Reson Imaging 15:10–27
Hendrikse J, Petersen ET, Golay X (2012) Vascular disorders: insights from arterial spin labeling. Neuroimaging Clin N Am 22:259–269
Heijtel DF, Mutsaerts HJ, Bakker E, Schober P, Stevens MF, Petersen ET, van Berckel BN, Majoie CB, Booij J, van Osch MJ, Vanbavel E, Boellaard R, Lammertsma AA, Nederveen AJ (2014) Accuracy and precision of pseudo-continuous arterial spin labeling perfusion during baseline and hypercapnia: a head-to-head comparison with 15O H2O positron emission tomography. Neuroimage 92:182–192
Petersen ET, Mouridsen K, Golay X (2010) The QUASAR reproducibility study, part II: results from a multi-center arterial spin labeling test-retest study. Neuroimage 49:104–113
Xu G, Rowley HA, Wu G, Alsop DC, Shankaranarayanan A, Dowling M, Christian BT, Oakes TR, Johnson SC (2010) Reliability and precision of pseudo-continuous arterial spin labeling perfusion MRI on 3.0 T and comparison with 15O-water PET in elderly subjects at risk for Alzheimer's disease. NMR Biomed 23:286–293
Mutsaerts HJ, van Osch MJ, Zelaya FO, Wang DJ, Nordhøy W, Wang Y, Wastling S, Fernandez-Seara MA, Petersen ET, Pizzini FB, Fallatah S, Hendrikse J, Geier O, Günther M, Golay X, Nederveen AJ, Bjørnerud A, Groote IR (2015) Multi-vendor reliability of arterial spin labeling perfusion MRI using a near-identical sequence: implications for multi-center studies. Neuroimage 113:143–152. doi:10.1016/j.neuroimage.2015.03.043 Epub 2015 Mar 24 PubMed PMID: 25818685
Deibler AR, Pollock JM, Kraft RA, Tan H, Burdette JH, Maldjian JA (2008) Arterial spin-labeling in routine clinical practice, part 2: hypoperfusion patterns. AJNR Am J Neuroradiol 29:1235–1241
Wang DJ, Chen Y, Fernandez-Seara MA, Detre JA (2011) Potentials and challenges for arterial spin labeling in pharmacological magnetic resonance imaging. J Pharmacol Exp Ther 337:359–366
De Vis JB, Hendrikse J, Bhogal A, Adams A, Kappelle LJ, Petersen ET (2015) Age-related changes in brain hemodynamics; a calibrated MRI study. Hum Brain Mapp 36(10):3973–3987
Ogawa S, Tank DW, Menon R, Ellermann JM, Kim SG, Merkle H, Ugurbil K (1992) Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci U S A 89:5951–5955
Buxton RB (2010) Interpreting oxygenation-based neuroimaging signals: the importance and the challenge of understanding brain oxygen metabolism. Front Neuroenerg 2:8. doi:10.3389/fnene.2010.00008
VJ S, Vannest J, Lee G, Hernandez-Garcia L, Plante E, Rajagopal A, SK H, CMIND Authorship Consortium (2015) Evidence that neurovascular coupling underlying the BOLD effect increases with age during childhood. Hum Brain Mapp 36(1):1–15
Aslan S, Xu F, Wang PL, Uh J, Yezhuvath US, van Osch M, Lu H (2010) Estimation of labeling efficiency in pseudocontinuous arterial spin labeling. Magn Reson Med 63(3):765–771
Alsop DC, Detre JA (1996) Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow. J Cereb Blood Flow Metab 16:1236–1249
Sardashti M, Schwartzberg DG, Stomp GP, Dixon WT (1990) Spin-labeling angiography of the carotids by presaturation and simplified adiabatic inversion. Magn Reson Med 15:192–200
Wolff SD, Balaban RS (1989) Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Reson Med 10:135–144
Alsop DC, Detre JA (1998) Multisection cerebral blood flow MRI imaging with continuous arterial spin labeling. Radiology 208:410–416
Golay X, Hendrikse J, Lim TCC (2004) Perfusion imaging using arterial spin labeling. Top Magn Reson Imaging 15:10–27
Edelman RR, Siewert B, Darby DG et al (1994) Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency. Radiology 192:513–520
Edelman RR, Chen Q (1998) EPISTAR MRI: multislice mapping of cerebral blood flow. Magn Reson Med 40:800–805
Wong EC, Buxton RB, Frank LR (1998) Quantitative imaging of perfusion using a single subtraction (QUIPSS and QUIPSS II). Magn Reson Med 39:702–708
GarciaDM, BazelaireCD, AlsopD (2005) Pseudo-continuous flow driven adiabatic inversion for arterial spin labeling. Scientific Meeting of the International Society for Magnetic Resonance in Medicine, Miami, p. 37
Dai W, Garcia D, De Bazelaire C, Alsop DC (2008) Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields. Magn Reson Med 60:1488–1497
Wu WC, Fernandez-Seara M, JA D et al (2007) A theoretical and experimental investigation of the tagging efficiency of pseudocontinuous arterial spin labeling. Magn Reson Med 58:1020–1027
Alsop DC, Detre JA, Golay X et al (2015) Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn Reson Med 73:102–116
Gevers S, Van Osch MJ, Bokkers RPH et al (2011) Intra- and multicenter reproducibility of pulsed, continuous and pseudocontinuous arterial spin labeling methods for measuring cerebral perfusion. J Cereb Blood Flow Metab 31:1706–1715
Garcia DM, Duhamel G, Alsop DC (2005) Efficiency of inversion pulses for background suppressed arterial spin labeling. Magn Reson Med 54:366–372
Lawrence KSS, Frank JA, Bandettini PA et al (2005) Noise reduction in multi-slice arterial spin tagging imaging. Magn Reson Med 53:735–738
Vidorreta M, Wang Z, Rodriguez I et al (2012) Comparison of 2D and 3D single-shot ASL perfusion fMRI sequences. Neuroimage 66C:662–671
Nielsen JF, Hernandez-Garcia L (2013) Functional perfusion imaging using pseudocontinuous arterial spin labeling with low flip angle segmented 3D spiral readouts. Magn Reson Med 69:382–390
Gunther M, Oshio K, Feinberg DA (2005) Single-shot 3D imaging techniques improve arterial spin labeling perfusion measurements. Magn Reson Med 54:491–498
Zaharchuk G, Do HM, Marks MP et al (2011) Arterial spin-labeling MRI can identify the presence and intensity of collateral perfusion in patients with moyamoya disease. Stroke 42:2485–2491
Le TT, Fischbein NJ, Andre JB et al (2012) Identification of venous signal on arterial spin labeling improves diagnosis of dural arteriovenous fistulas and small arteriovenous malformations. AJNR Am J Neuroradiol 33:61–68
Wolf RL, Wang J, Detre JA et al (2008) Arteriovenous shunt visualization in arteriovenous malformations with arterial spin labeling MR imaging. AJNR Am J Neuroradiol 29:681–687
Buxton RB, Frank LR, Wong EC et al (1998) A general kinetic model for quantitative perfusion imaging with arterial spin labeling. Magn Reson Med 40:383–396
Wong EC, Buxton RB, Frank LR (1997) Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling. NMR Biomed 10:237–249
Wong EC, Buxton RB, Frank LR (1998) A theoretical and experimental comparison of continuous and pulsed arterial spin labeling techniques for quantitative perfusion imaging. Magn Reson Med 40:348–355
MaccaroneM, EspositoR, SaliceS, et al. (2015) Quantitative MR R2* imaging and arterial spin labeling brain perfusion assessment in alzheimer disease. Radiological Society of North America 2015 Scientific Assembly and Annual Meeting, November 29–December 4, 2015, Chicago. archive.rsna.org/2015/15016539.html
Gunther M, Bock M, Schad LR (2001) Arterial spin labeling in combination with a Look-Locker sampling strategy: inflow turbo-sampling EPI- FAIR (ITS-FAIR). Magn Reson Med 46:974–984
Petersen ET, Lim T, Golay X (2006) Model-free arterial spin labeling quantification approach for perfusion MRI. Magn Reson Med 55:219–232
Francis ST, Bowtell R, Gowland PA (2008) Modeling and optimization of Look-Locker spin labeling for measuring perfusion and transit time changes in activation studies taking into account arterial blood volume. Magn Reson Med 59:316–325
Dai W, Robson PM, Shankaranarayanan A et al (2012) Reduced resolution transit delay prescan for quantitative continuous arterial spin labeling perfusion imaging. Magn Reson Med 67:1252–1265
Wang DJ, Alger JR, Qiao JX et al (2013) Multi-delay multi-parametric arterial spin-labeled perfusion MRI in acute ischemic stroke—comparison with dynamic susceptibility contrast enhanced perfusion imaging. NeuroImage Clin 3:1–7
van Laar PJ, van der Grond J, Hendrikse J (2008) Brain perfusion territory imaging: methods and clinical applications of selective arterial spin- labeling MR imaging. Radiology 246:354–364
Paiva FF, Tannus A, Silva AC (2007) Measurement of cerebral perfusion territories using arterial spin labelling. NMR Biomed 20:633–642
Hendrikse J, van Raamt AF, van der Graaf Y et al (2005) Distribution of cerebral blood flow in the circle of Willis. Radiology 235(1):184–189
Hendrikse J, van der Grond J, Lu H et al (2004) Flow territory mapping of the cerebral arteries with regional perfusion MRI. Stroke 35(4):882–887
Hendrikse J, van Osch MJ, van der Zwan A et al (2005) Altered flow territories after extracranial to intracranial by- pass surgery: clinical implementation of selective arterial spin labeling MRI. Proc Intl Soc Mag Reson Med 13:1137
van Laar PJ, Hendrikse J, Golay X et al (2005) In-vivo flow territory mapping of major brain feeding arteries: a population study with selective arterial spin labeling MRI. Proc Int Soc Mag Reson Med 13:1134
Kwong KK, Belliveau JW, Chesler DA et al (1992) Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci U S A 89:5675–5679
Bandettini PA, Wong EC, Hinks RS et al (1992) Time course EPI of human brain function during task activation. Magn Reson Med 25:390–397
Ogawa S, Tank DW, Menon R et al (1992) Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci U S A 89:5951–5955
Ances BM, Leontiev O, Perthen JE et al (2008) Regional differences in the coupling of cerebral blood flow and oxygen metabolism changes in response to activation: implications for BOLD-fMRI. Neuroimage 39:1510–1521
Buxton RB (2010) Interpreting oxygenation-based neuroimaging signals: the importance and the challenge of understanding brain oxygen metabolism. Front Neuroenerg 2:8. http://dx.doi.org/10.3389/fnene.2010.00008
Griffeth VEM, Perthen JE, Buxton RB (2011) Prospects for quantitative fMRI: investigating the effects of caffeine on baseline oxygen metabolism and the response to a visual stimulus in humans. Neuroimage 57:809–816
Moradi F, Buracas GT, Buxton RB (2012) Attention strongly increases oxygen metabolic response to stimulus in primary visual cortex. Neuroimage 59:601–607
Liu TT (2013) Neurovascular factors in resting-state functional MRI. Neuroimage 80:339–348
Mohtasib RS, Lumley G, Goodwin JA et al (2012) Calibrated fMRI during a cognitive Stroop task reveals reduced metabolic response with increasing age. Neuroimage 59:1143–1151
Blockley NP, Griffeth VE, Simon AB et al (2013) A review of calibrated blood oxygenation level-dependent (BOLD) methods for the measurement of task-induced changes in brain oxygen metabolism. NMR Biomed 26:987–1003
Davis TL, Kwong KK, Weisskoff RM et al (1998) Calibrated functional MRI: mapping the dynamics of oxidative metabolism. Proc Natl Acad Sci U S A 95:1834–1839
Wise RG, Harris AD, Stone AJ et al (2013) Measurement of OEF and absolute CMRO2: MRI-based methods using interleaved and combined hypercapnia and hyperoxia. Neuroimage 83:135–147
Bulte DP, Kelly M, Germuska M et al (2012) Quantitative measurement of cerebral physiology using respiratory-calibrated MRI. Neuroimage 60:582–591
Zhang N, Zhu XH, Chen W (2008) Investigating the source of BOLD nonlinearity in human visual cortex in response to paired visual stimuli. Neuroimage 43:204–212
Zhang N, Yacoub E, Zhu XH et al (2009) Linearity of blood-oxygenation-level dependent signal at microvasculature. Neuroimage 48:313–318
Chiacchiaretta P, Ferretti A (2015) Resting state BOLD functional connectivity at 3 T: spin echo versus gradient echo EPI. PLoS One 10(3):e0120398. doi:10.1371/journal.pone.0120398
Chiacchiaretta P, Romani GL, Ferretti A (2013) Sensitivity of BOLD response to increasing visual contrast: spin echo versus gradient echo EPI. Neuroimage 82:35–43
Uludağ K, Müller-Bierl B, Uğurbil K (2009) An integrative model for neuronal activity-induced signal changes for gradient and spin echo functional imaging. Neuroimage 48:150–165
Norris DG (2012) Spin-echo fMRI: The poor relation? Neuroimage 62:1109–1115
Diekhoff S, Uludag K, Sparing R et al (2011) Functional localization in the human brain: gradient-echo, spin-echo, and arterial spin-labeling fMRI compared with neuronavigated TMS. Hum BrainMapp 32:341–357
Raoult H, Petr J, Bannier EC et al (2011) Arterial spin labeling for motor activation mapping at 3 T with a 32-channel coil: reproducibility and spatial accuracy in comparison with BOLD fMRI. Neuroimage 58:157–167
Tjandra T, Brooks JC, Figueiredo P et al (2005) Quantitative assessment of the reproducibility of functional activation measured with BOLD and MR perfusion imaging: implications for clinical trial design. Neuroimage 27:393–401
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Chiacchiaretta, P., Tartaro, A., Salice, S., Ferretti, A. (2017). ASL 3.0 T Perfusion Studies. In: Scarabino, T., Pollice, S., Popolizio, T. (eds) High Field Brain MRI. Springer, Cham. https://doi.org/10.1007/978-3-319-44174-0_10
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