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Regulation of Carbohydrate Metabolism, Lipid Metabolism, and Protein Metabolism by AMPK

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AMP-activated Protein Kinase

Part of the book series: Experientia Supplementum ((EXS,volume 107))

Abstract

This chapter summarizes AMPK function in the regulation of substrate and energy metabolism with the main emphasis on carbohydrate and lipid metabolism, protein turnover, mitochondrial biogenesis, and whole-body energy homeostasis. AMPK acts as whole-body energy sensor and integrates different signaling pathway to meet both cellular and body energy requirements while inhibiting energy-consuming processes but also activating energy-producing ones. AMPK mainly promotes glucose and fatty acid catabolism, whereas it prevents protein, glycogen, and fatty acid synthesis.

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Authors and Affiliations

  1. Pole of Cardiovascular Research, Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Brussels, Belgium

    Yeliz Angin, Christophe Beauloye, Sandrine Horman & Luc Bertrand

  2. Division of Cardiology, Cliniques universitaires Saint-Luc, Brussels, Belgium

    Christophe Beauloye

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  1. Yeliz Angin
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  2. Christophe Beauloye
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  3. Sandrine Horman
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  4. Luc Bertrand
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Correspondence to Luc Bertrand .

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Editors and Affiliations

  1. Oral Medicine Department, Universidad de Sevilla, Sevilla, Spain

    Mario D. Cordero

  2. INSERM U1016 Institut Cochin CNRS UMR 8104, Université Paris Descartes, Paris, France

    Benoit Viollet

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Angin, Y., Beauloye, C., Horman, S., Bertrand, L. (2016). Regulation of Carbohydrate Metabolism, Lipid Metabolism, and Protein Metabolism by AMPK. In: Cordero, M., Viollet, B. (eds) AMP-activated Protein Kinase. Experientia Supplementum, vol 107. Springer, Cham. https://doi.org/10.1007/978-3-319-43589-3_2

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