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5′-AMP-Activated Protein Kinase Signaling in Caenorhabditis elegans

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AMP-activated Protein Kinase

Part of the book series: Experientia Supplementum ((EXS,volume 107))

Abstract

AMP-activated protein kinase (AMPK) is one of the central regulators of cellular and organismal metabolism in eukaryotes. Once activated by decreased energy levels, it induces ATP production by promoting catabolic pathways while conserving ATP by inhibiting anabolic pathways. AMPK plays a crucial role in various aspects of cellular function such as regulating growth, reprogramming metabolism, autophagy, and cell polarity. In this chapter, we focus on how recent breakthroughs made using the model organism Caenorhabditis elegans have contributed to our understanding of AMPK function and how it can be utilized in the future to elucidate hitherto unknown aspects of AMPK signaling.

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Authors and Affiliations

  1. Department of Biology, McGill University, 1205 Avenue Docteur Penfield, Montreal, QC, Canada, H3A 1B1

    Moloud Ahmadi & Richard Roy

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  1. Moloud Ahmadi
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  2. Richard Roy
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Correspondence to Richard Roy .

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Editors and Affiliations

  1. Oral Medicine Department, Universidad de Sevilla, Sevilla, Spain

    Mario D. Cordero

  2. INSERM U1016 Institut Cochin CNRS UMR 8104, Université Paris Descartes, Paris, France

    Benoit Viollet

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Ahmadi, M., Roy, R. (2016). 5′-AMP-Activated Protein Kinase Signaling in Caenorhabditis elegans . In: Cordero, M., Viollet, B. (eds) AMP-activated Protein Kinase. Experientia Supplementum, vol 107. Springer, Cham. https://doi.org/10.1007/978-3-319-43589-3_15

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