Abstract
Although pediatric malignancies are rare, approximately 17% of children diagnosed with cancer will die of their disease or treatment related complications. The appropriate palliative care of pediatric cancer patients encompasses quality of life, minimizes suffering, optimizes functioning, and provides support for spiritual, psychosocial, and personal growth. Care required by pediatric cancer patients differs from the care of adult cancer patient care because of different types of common malignancies, expected disease presentations, various stages of cognitive, emotional, and spiritual development, treatments available and response. The limited defined best practices of pediatric palliative radiotherapy have already demonstrated effectiveness of radiotherapy in relieving symptoms from progressive and metastatic disease involving bone, soft tissue, and solid organs. Pediatric oncology patients undergoing palliative radiotherapy in conjunction with an evolving interdisciplinary approach benefit from honest and unarmed communication, systematic symptom management, and incorporation of innovative research and technology for optimal support for the patient, family, and primary care team.
References
Alderfer MA, Long KA, Lown EA, Marsland AL, Ostrowski NL, Hock JM, Ewing LJ (2010) Psychosocial adjustment of siblings of children with cancer: a systematic review. Psychooncology 19:789–805
Allen J (1990) Brain metastases. In: Deutsch M (ed) Management of childhood brain tumors. Kluwer Academic Publishers, Boston, MA
American Cancer Society (2014) Cancer treatment & survivorship facts & figures 2012–2013
American Cancer Society I. Cancer facts & figures 2017. Available at: http://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2017/cancer-facts-and-figures-2017.pdf. Accessed 01/23/2017. 2017)
Anderson PM, Wiseman GA, Dispenzieri A, Arndt CA, Hartmann LC, Smithson WA, Mullan BP, Bruland OS (2002) High-dose samarium-153 ethylene diamine tetramethylene phosphonate: low toxicity of skeletal irradiation in patients with osteosarcoma and bone metastases. J Clin Oncol 20:189–196
Arya LS, Narain S, Tomar S, Thavaraj V, Dawar R, Bhargawa M (2002) Superior vena cava syndrome. Indian J Pediatr 69:293–297
Back AL, Arnold RM, Baile WF, Fryer-Edwards KA, Alexander SC, Barley GE, Gooley TA, Tulsky JA (2007) Efficacy of communication skills training for giving bad news and discussing transitions to palliative care. Arch Intern Med 167:453–460
Baile WF, Buckman R, Lenzi R, Glober G, Beale EA, Kudelka AP (2000) Spikes-A six-step protocol for delivering bad news: application to the patient with cancer. Oncologist 5:302–311
Baker JN, Kane JR, Rai S, Howard SC, Hinds PS, PCS Research Working Group (2010) Changes in medical care at a pediatric oncology referral center after placement of a do-not-resuscitate order. J Palliat Med 13:1349–1352
Bakst RL, Dunkel IJ, Gilheeney S, Khakoo Y, Becher O, Souweidane MM, Wolden SL (2011) Reirradiation for recurrent medulloblastoma. Cancer 117:4977–4982
Baten M, Vannucci RC (1977) Intraspinal metastatic disease in childhood cancer. J Pediatr 90:207–212
Bertsch H, Rudoler S, Needle MN, Malloy P, Sutton L, Belasco J, Meadows A, Goldwein J (1998) Emergent/urgent therapeutic irradiation in pediatric oncology: patterns of presentation, treatment, and outcome. Med Pediatr Oncol 30:101–105
Bleyer A (2007) Young adult oncology: the patients and their survival challenges. CA Cancer J Clin 57:242–255
Block SD (2001) Perspectives on care at the close of life. Psychological considerations, growth, and transcendence at the end of life: the art of the possible. JAMA 285(22):2898–2905
Bluebond-Lagner M (1978) The private world of dying children. Princeton University Press, Princeton, NJ
Boman K, Lindahl A, Bjork O (2003) Disease-related distress in parents of children with cancer at various stages after the time of diagnosis. Acta Oncol 42:137–146
Bona K, Bates J, Wolfe J (2011) Massachusetts’ pediatric palliative care network: successful implementation of a novel state-funded pediatric palliative care program. J Palliat Med 14:1217–1223
Bone Pain Trial Working Party (1999) 8 Gy single fraction radiotherapy for the treatment of metastatic skeletal pain: randomised comparison with a multifraction schedule over 12 months of patient follow-up. Bone Pain Trial Working Party. Radiother Oncol 52(2):111–121
Botsa E, Poulou LS, Koutsogiannis I, Ziakas PD, Koundouraki A, Alexopoulou E, Thanos L (2014) CT-guided radiofrequency tumor ablation in children. Pediatr Radiol 44:1421–1425
Bouffet E, Doumi N, Thiesse P, Mottolese C, Jouvet A, Lacroze M, Carrie C, Frappaz D, Brunat-Mentigny M (1997) Brain metastases in children with solid tumors. Cancer 79:403–410
Brown AP, Barney CL, Grosshans DR, Mcaleer MF, de Groot JF, Puduvalli VK, Tucker SL, Crawford CN, Khan M, Khatua S, Gilbert MR, Brown PD, Mahajan A (2013) Proton beam craniospinal irradiation reduces acute toxicity for adults with medulloblastoma. Int J Radiat Oncol Biol Phys 86:277–284
Brown LC, Lester RA, Grams MP, Haddock MG, Olivier KR, Arndt CA, Rose PS, Laack NN (2014) Stereotactic body radiotherapy for metastatic and recurrent Ewing sarcoma and osteosarcoma. Sarcoma 2014:418270
Brown PG (1989) Families who have a child diagnosed with cancer: what the medical caregiver can do to help them and themselves. Issues Compr Pediatr Nurs 12:247–260
Bruckman JE, Bloomer WD (1978) Management of spinal cord compression. Semin Oncol 5:135–140
Buyukavci M, Karacan M, Olgan H, Tan H (2003) Significance of bone marrow examination in the diagnostic process of paraspinal mass in children: a case report. J Pediatr Hematol Oncol 25(10):822–823
Caussa L, Hijal T, Michon J, Helfre S (2011) Role of palliative radiotherapy in the management of metastatic pediatric neuroblastoma: a retrospective single-institution study. Int J Radiat Oncol Biol Phys 79(1):214–219
Ch’ien LT, Kalwinsky DK, Peterson G, Pratt CB, Murphy SB, Hayes FA, Green AA, Hustu HO (1982) Metastatic epidural tumors in children. Med Pediatr Oncol 10:455–462
Cohen LL, Lemanek K, Blount RL, Dahlquist LM, Lim CS, Palermo TM, Mckenna KD, Weiss KE (2008) Evidence-based assessment of pediatric pain. J Pediatr Psychol 33:939–955; discussion 956–7
Collins JJ, Byrnes ME, Dunkel IJ, Lapin J, Nadel T, Thaler HT, Polyak T, Rapkin B, Portenoy RK (2000) The measurement of symptoms in children with cancer. J Pain Symptom Manag 19:363–377
Collins JJ, Devine TD, Dick GS, Johnson EA, Kilham HA, Pinkerton CR, Stevens MM, Thaler HT, Portenoy RK (2002) The measurement of symptoms in young children with cancer: the validation of the Memorial Symptom Assessment Scale in children aged 7–12. J Pain Symptom Manag 23:10–16
Contro N, Larson J, Scofield S, Sourkes B, Cohen H (2002) Family perspectives on the quality of pediatric palliative care. Arch Pediatr Adolesc Med 156:14–19
D’angio GJ, Mitos A, Evans AE (1965) The superior mediastinal syndrome in children with cancer. Am J Roentgenol Radium Therapy, Nucl Med 93:537–544
Davies AM (2001) Death of adolescents: parental grief and coping strategies. Br J Nurs 10(20):1332–1342
De Bernardi B, Pianca C, Pistamiglio P, Veneselli E, Viscardi E, Pession A, Alvisi P, Carli M, Donfrancesco A, Casale F, Giuliano MG, di Montezemolo LC, di Cataldo A, Lo Curto M, Bagnulo S, Schumacher RF, Tamburini A, Garaventa A, Clemente L, Bruzzi P (2001) Neuroblastoma with symptomatic spinal cord compression at diagnosis: treatment and results with 76 cases. J Clin Oncol 19:183–190
De Vries MC, Wit JM, Engberts DP, Kaspers GJ, van Leeuwen E (2010) Pediatric oncologists’ attitudes towards involving adolescents in decision-making concerning research participation. Pediatr Blood Cancer 55:123–128
Decinque N, Monterosso L, Dadd G, Sidhu R, Macpherson R, Aoun S (2006) Bereavement support for families following the death of a child from cancer: experience of bereaved parents. J Psychosoc Oncol 24:65–83
Deutsch M, Albo V, Wollman MR (1982) Radiotherapy for cerebral metastases in children. Int J Radiat Oncol Biol Phys 8:1441–1446
Deutsch M, Orlando S, Wollman M (2002) Radiotherapy for metastases to the brain in children. Med Pediatr Oncol 39:60–62
Deutsch M, Tersak JM (2004) Radiotherapy for symptomatic metastases to bone in children. Am J Clin Oncol 27:128–131
Dingfield L, Bender L, Harris P, Newport K, Hoover-Regan M, Feudtner C, Clifford S, Casarett D (2015) Comparison of pediatric and adult hospice patients using electronic medical record data from nine hospices in the United States, 2008–2012. J Palliat Med 18:120–126
Dubois S, Bender J, Krailo M, Arndt C, Gorlick R, Marina N, Daldrup-Link H, Janeway K, Kolb E, Reed D, Laack N, Lessnick S, Rakheja D, Randall R, Reid R, Terezakis S, Teot L, Womer R, Hayes-Jordan A, Whiteside S, Hill-Kayser C, Strickland B, Lee W, Lu H, Tustin C, Stahlman M (2014) AEWS1221-Randomized Phase II Evaluated the addition of IGF-1R monoclonal antibody Ganitumab (AMG 479. NSC#750008, IND#120449) to multiagent chemotherapy for patients; Children’s Oncology Group. (PROTOCOL)
Dupuis LL, Milne-Wren C, Cassidy M, Barrera M, Portwine C, Johnston DL, Silva MP, Sibbald C, Leaker M, Routh S, Sung L (2010) Symptom assessment in children receiving cancer therapy: the parents’ perspective. Support Care Cancer 18:281–299
Durall A, Zurakowski D, Wolfe J (2012) Barriers to conducting advance care discussions for children with life-threatening conditions. Pediatrics 129:e975–e982
Dussel V, Kreicbergs U, Hilden JM, Watterson J, Moore C, Turner BG, Weeks JC, Wolfe J (2009) Looking beyond where children die: determinants and effects of planning a child’s location of death. J Pain Symptom Manag 37:33–43
Dyregrov A, Dyregrov K (1999) Long-term impact of sudden infant death: a 12- to 15-year follow-up. Death Stud 23:635–661
Fabian CJ, Mansfield CM, Dahlberg S, Jones SE, Miller TP, Van Slyck E, Grozea PN, Morrison FS, Coltman CA Jr, Fisher RI (1994) Low-dose involved field radiation after chemotherapy in advanced Hodgkin disease. A Southwest Oncology Group randomized study. Ann Intern Med 120:903–912
Ferrari LR, Bedford RF (1990) General anesthesia prior to treatment of anterior mediastinal masses in pediatric cancer patients. Anesthesiology 72:991–995
Foley F (2004) Acute and chronic cancer pain syndromes. In: Doyle D, Hanks G, Cherny N, Calman K (eds) Textbook of palliative medicine, 3rd edn. Oxford University Press, Oxford, UK
Foley K, Gelband H (2001) Improving palliative care for cancer: summary and recommendations. In: Foley KM, Gelband H (eds) National cancer policy board, national research council. National Academies Press, Washington, DC
Foley KM (1987) Pain syndromes in patients with cancer. Med Clin North Am 71:169–184
Friebert S (2015) National Hospice and Palliative Care Organization. 2015 NHPCO Facts and Figures: Pediatric Palliative and Hospice Care in America. www.nhpco.org
Gaab EM, Owens GR, Macleod RD (2014) Siblings caring for and about pediatric palliative care patients. J Palliat Med 17:62–67
Garwick AW, Patterson J, Bennett FC, Blum RW (1995) Breaking the news. How families first learn about their child’s chronic condition. Arch Pediatr Adolesc Med 149:991–997
Gilbert RW, Kim JH, Posner JB (1978) Epidural spinal cord compression from metastatic tumor: diagnosis and treatment. Ann Neurol 3:40–51
Graus F, Walker RW, Allen JC (1983) Brain metastases in children. J Pediatr 103:558–561
Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, Gebhardt MC, Dickman PS, Perlman EJ, Meyers PA, Donaldson SS, Moore S, Rausen AR, Vietti TJ, Miser JS (2003) Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 348:694–701
Gupta V, Srivastava A, Bhatia B (2009) Hodgkin disease with spinal cord compression. J Pediatr Hematol Oncol 31:771–773
Hain R, Heckford E, Mcculloch R (2012) Paediatric palliative medicine in the UK: past, present, future. Arch Dis Child 97:381–384
Hamama R, Ronen T, Feigin R (2000) Self-control, anxiety, and loneliness in siblings of children with cancer. Soc Work Health Care 31:63–83
Hartsell WF, Scott CB, Bruner DW, Scarantino CW, Ivker RA, Roach M 3rd, Suh JH, Demas WF, Movsas B, Petersen IA, Konski AA, Cleeland CS, Janjan NA, Desilvio M (2005) Randomized trial of short- versus long-course radiotherapy for palliation of painful bone metastases. J Natl Cancer Inst 97:798–804
Hayes FA, Thompson EI, Hvizdala E, O’connor D, Green AA (1984) Chemotherapy as an alternative to laminectomy and radiation in the management of epidural tumor. J Pediatr 104:221–224
Hechler T, Blankenburg M, Friedrichsdorf SJ, Garske D, Hubner B, Menke A, Wamsler C, Wolfe J, Zernikow B (2008) Parents’ perspective on symptoms, quality of life, characteristics of death and end-of-life decisions for children dying from cancer. Klin Padiatr 220:166–174
Heden L, Poder U, von Essen L, Ljungman G (2013) Parents’ perceptions of their child’s symptom burden during and after cancer treatment. J Pain Symptom Manag 46:366–375
Hendrickson KC (2009) Morbidity, mortality, and parental grief: a review of the literature on the relationship between the death of a child and the subsequent health of parents. Palliat Support Care 7:109–119
Hilden JM, Emanuel EJ, Fairclough DL, Link MP, Foley KM, Clarridge BC, Schnipper LE, Mayer RJ (2001) Attitudes and practices among pediatric oncologists regarding end-of-life care: results of the 1998 American Society of Clinical Oncology survey. J Clin Oncol 19:205–212
Himelstein BP, Hilden JM, Boldt AM, Weissman D (2004) Pediatric palliative care. N Engl J Med 350:1752–1762
Hinds PS, Drew D, Oakes LL, Fouladi M, Spunt SL, Church C, Furman WL (2005) End-of-life care preferences of pediatric patients with cancer. J Clin Oncol 23:9146–9154
Hinds PS, Oakes L, Furman W, Foppiano P, Olson MS, Quargnenti A, Gattuso J, Powell B, Srivastava DK, Jayawardene D, Sandlund JT, Strong C (1997) Decision making by parents and healthcare professionals when considering continued care for pediatric patients with cancer. Oncol Nurs Forum 24:1523–1528
Holgersen LO, Santulli TV, Schullinger JN, Berdon WE (1983) Neuroblastoma with intraspinal (dumbbell) extension. J Pediatr Surg 18:406–411
Houlahan KE, Branowicki PA, Mack JW, Dinning C, Mccabe M (2006) Can end of life care for the pediatric patient suffering with escalating and intractable symptoms be improved? J Pediatr Oncol Nurs 23:45–51
Howlander N, Noone A, Krapcho M, Garshell J, Miller D, Alterkruse S, Kosary C, Yu M, Ruh LJ, Tatalouvich Z, Mariotto A, Lewis D, Chen H, Feuer E, Conin KE (2016) SEER cancer statistics review, 1975–2013. National Cancer Institute, Bethesda, MD. Available at: http://seer.cancer.gov/csr/1975_2013
Hui D, Elsayem A, De La Cruz M, Berger A, Zhukovsky DS, Palla S, Evans A, Fadul N, Palmer JL, Bruera E (2010) Availability and integration of palliative care at US cancer centers. JAMA 303:1054–1061
Hurwitz CA, Duncan J, Wolfe J (2004) Caring for the child with cancer at the close of life. “There are people who make it, and I’m hoping I’m one of them”. JAMA 292(17):2141–2149
Ingram L, Rivera GK, Shapiro DN (1990) Superior vena cava syndrome associated with childhood malignancy: analysis of 24 cases. Med Pediatr Oncol 18:476–481
Iqbal Y, Al-Sudairy R, Abdullah MF, Rafaie T, Al-Omari A (2003) Spinal cord compression as an initial symptom in childhood acute lymphoblastic leukemia: rapid decompression with high dose dexamethasone and chemotherapy alone. Ann Saudi Med 23(3-4):179–180
Isome K, Matsubara K, Taki T, Nigami H, Yura K, Iwata A, Wada T, Taniwaki M, Fukaya T (2011) Spinal cord compression by epidural involvement over 21 vertebral levels in acute lymphoblastic leukemia. J Pediatr Hematol Oncol 33(2):153–157
Kane J, Hilden J (2007) Tools to aid decision-making in the care of pediatric patients with cancer. American Society of Clinical Oncology Educational Book, Alexandria, VA
Jenkin RD, Berry MP (1983) Sequential half-body irradiation in childhood. Int J Radiat Oncol Biol Phys 9:1969–1971
Kang T, Hoehn KS, Licht DJ, Mayer OH, Santucci G, Carroll JM, Long CM, Hill MA, Lemisch J, Rourke MT, Feudtner C (2005) Pediatric palliative, end-of-life, and bereavement care. Pediatr Clin N Am 52:1029–1046, viii
Kataoka A, Shimmizu K, Matsumoto T, Shintaky N, Okuno T, Takahashi Y, Akaishi K (1995) Epidural spinal cord compression as an initial symptom in childhood acute lymphoblastic leukemia: rapid decompression by local irradiation and systemic chemotherapy. Pediatr Hematol Oncol 12(2):179–184
Kaye EA, Pauly KB (2013) Adapting MRI acoustic radiation force imaging for in vivo human brain focused ultrasound applications. Magn Reson Med 69:724–733
Keshavarzi S, Meltzer H, Ben-Haim S, Newman CB, Lawson JD, Levy ML, Murphy K (2009) Initial clinical experience with frameless optically guided stereotactic radiosurgery/radiotherapy in pediatric patients. Childs Nerv Syst 25:837–844
Khaneja S, Milrod B (1998) Educational needs among pediatricians regarding caring for terminally ill children. Arch Pediatr Adolesc Med 152:909–914
Kilicarslan-Toruner E, Akgun-Citak E (2013) Information-seeking behaviours and decision-making process of parents of children with cancer. Eur J Oncol Nurs 17:176–183
King D, Connolly D, Zaki H, Lee V, Yeomanson D (2014) Successful treatment of metastatic relapse of medulloblastoma in childhood with single session stereotactic radiosurgery: a report of 3 cases. J Pediatr Hematol Oncol 36:301–304
King RM, Telander RL, Smithson WA, Banks PM, Han MT (1982) Primary mediastinal tumors in children. J Pediatr Surg 17:512–520
Klein SL, Sanford RA, Muhlbauer MS (1991) Pediatric spinal epidural metastases. J Neurosurg 74:70–75
Knapp C, Madden V, Sloyer P, Shenkman E (2012) Effects of an Integrated Care System on quality of care and satisfaction for children with special health care needs. Matern Child Health J 16:579–586
Koontz BF, Clough RW, Halperin EC (2006) Palliative radiation therapy for metastatic Ewing sarcoma. Cancer 106:1790–1793
Kozlowski K, Beluffi G, Masel J, Diard F, Ferrari-Ciboldi F, Le Dosseur P, Labatut J (1984) Primary vertebral tumours in children. Report of 20 cases with brief literature review. Pediatr Radiol 14:129–139
Krakauer R, Spettell CM, Reisman L, Wade MJ (2009) Opportunities to improve the quality of care for advanced illness. Health Aff (Millwood) 28:1357–1359
Kreicbergs U, Valdimarsdottir U, Onelov E, Bjork O, Steineck G, Henter JI (2005) Care-related distress: a nationwide study of parents who lost their child to cancer. J Clin Oncol 23:9162–9171
Kreicbergs U, Valdimarsdottir U, Onelov E, Henter JI, Steineck G (2004) Talking about death with children who have severe malignant disease. N Engl J Med 351:1175–1186
Kreicbergs UC, Lannen P, Onelov E, Wolfe J (2007) Parental grief after losing a child to cancer: impact of professional and social support on long-term outcomes. J Clin Oncol 25:3307–3312
Kumari I, Gupta S, Singhal PP (2006) Superior vena caval syndrome in children--A case report. Middle East J Anaesthesiol 18:933–938
Lamont EB, Christakis NA (2003) Complexities in prognostication in advanced cancer: "to help them live their lives the way they want to". JAMA 290:98–104
Lange B, D’angio G, Ross IA, O’neill JJ, Packer R (1993) Oncologic emergencies. In: Pizzo PA, Poplack DG (eds) Principles and practice of pediatric oncology, 2nd edn. J.B. Lippincott, Philadelphia, PA
Lewis DW, Packer RJ, Raney B, Rak IW, Belasco J, Lange B (1986) Incidence, presentation, and outcome of spinal cord disease in children with systemic cancer. Pediatrics 78:438–443
Liben S (1996) Pediatric palliative medicine: obstacles to overcome. J Palliat Care 12:24–28
Liben S, Papadatou D, Wolfe J (2008) Paediatric palliative care: challenges and emerging ideas. Lancet 371:852–864
Little J (1999) Epidemiology of childhood cancer. IARC Sci Publ:1–386
Loeffler JS, Leopold KA, Recht A, Weinstein HJ, Tarbell NJ (1986) Emergency prebiopsy radiation for mediastinal masses: impact on subsequent pathologic diagnosis and outcome. J Clin Oncol 4:716–721
Lyding JM, Tseng A, Newman A, Collins S, Shea W (1987) Intramedullary spinal cord metastasis in Hodgkin’s disease. Rapid diagnosis and treatment resulting in neurologic recovery. Cancer 60:1741–1744
Mack JW, Cook EF, Wolfe J, Grier HE, Cleary PD, Weeks JC (2007) Understanding of prognosis among parents of children with cancer: parental optimism and the parent-physician interaction. J Clin Oncol 25:1357–1362
Mack JW, Hilden JM, Watterson J, Moore C, Turner B, Grier HE, Weeks JC, Wolfe J (2005) Parent and physician perspectives on quality of care at the end of life in children with cancer. J Clin Oncol 23:9155–9161
Mack JW, Joffe S, Hilden JM, Watterson J, Moore C, Weeks JC, Wolfe J (2008) Parents’ views of cancer-directed therapy for children with no realistic chance for cure. J Clin Oncol 26:4759–4764
Mack JW, Wolfe J, Grier HE, Cleary PD, Weeks JC (2006) Communication about prognosis between parents and physicians of children with cancer: parent preferences and the impact of prognostic information. J Clin Oncol 24:5265–5270
Mack JW, Wolfe J, Cook EF, Grier HE, Cleary PD, Weeks JC (2011) Parents’ roles in decision making for children with cancer in the first year of cancer treatment. J Clin Oncol 201129(15):2085–2090
Macrae R, Grimard L, Hsu E, Nizalik E, Halton JM (2002) Brain metastases in Wilms’ tumor: case report and literature review. J Pediatr Hematol Oncol 24:149–153
Makoul G (2003) MSJAMA. Communication skills education in medical school and beyond. JAMA 289:93
Martinson IM (1995) Improving care of dying children. West J Med 163:258–262
Martinson IM, Mcclowry SG, Davies B, Kuhlenkamp EJ (1994) Changes over time: a study of family bereavement following childhood cancer. J Palliat Care 10:19–25
Masera G, Chesler MA, Jankovic M, Ablin AR, Ben Arush MW, Breatnach F, Mcdowell HP, Eden T, Epelman C, Fossati Bellani F, Green DM, Kosmidis HV, Nesbit ME, Wandzura C, Wilbur JR, Spinetta JJ (1997) SIOP Working Committee on psychosocial issues in pediatric oncology: guidelines for communication of the diagnosis. Med Pediatr Oncol 28:382–385
Mostafavi H, Lennarson PJ, Traynelis VC (2000) Granulocytic sarcoma of the spine. Neurosurgery 46(1):78–83; discussion 83–84
Mu PF, Lee MY, Sheng CC, Tung PC, Huang LY, Chen YW (2015) The experiences of family members in the year following the diagnosis of a child or adolescent with cancer: a qualitative systematic review. JBI Database System Rev Implement Rep 13:293–329
Mulhern RK, Crisco JJ, Camitta BM (1981) Patterns of communication among pediatric patients with leukemia, parents, and physicians: prognostic disagreements and misunderstandings. J Pediatr 99:480–483
Nanda R, Dhabbaan A, Janss A, Shu HK, Esiashvili N (2014) The feasibility of frameless stereotactic radiosurgery in the management of pediatric central nervous system tumors. J Neuro-Oncol 117:329–335
Nolbris M, Abrahamsson J, Hellstrom AL, Olofsson L, Enskar K (2010) The experience of therapeutic support groups by siblings of children with cancer. Pediatr Nurs 36:298–304; quiz 305
Ortega JA, Wharam M, Gehan EA, Ragab AH, Crist W, Webber B, Wiener ES, Haeberlen V, Maurer HM (1991) Clinical features and results of therapy for children with paraspinal soft tissue sarcoma: a report of the Intergroup Rhabdomyosarcoma Study. J Clin Oncol 9:796–801
Oviatt DL, Kirshner HS, Stein RS (1982) Successful chemotherapeutic treatment of epidural compression in non-Hodgkin’s lymphoma. Cancer 49:2446–2448
Padovani L, Andre N, Gentet JC, Figarella Branger D, Scavarda D, Verschuur A, Chinot O, Cowen D, Muracciole X (2011) Reirradiation and concomitant metronomic temozolomide: an efficient combination for local control in medulloblastoma disease? J Pediatr Hematol Oncol 33:600–604
Parikh RB, Kirch RA, Smith TJ, Temel JS (2013) Early specialty palliative care--translating data in oncology into practice. N Engl J Med 369:2347–2351
Paulino AC (2003) Palliative radiotherapy in children with neuroblastoma. Pediatr Hematol Oncol 20:111–117
PCEP (2015) Palliative care education and practice series. Harvard Medical School
Periyakoil VS, Neri E, Kraemer H (2015) Patient-reported barriers to high-quality, end-of-life care: a multiethnic, multilingual, mixed-methods study. J Palliat Med 19(4):373–379
Pizzo PA, Poplack DG, Horowitz ME, Hays DM, Kun LE (1993) Solid tumors of childhood. In: DeVita VT, Lawrence TS, Rosenberg SA (eds) Cancer: principles & practice of oncology, 4th edn. J.B. Lippincott, Philadelphia, PA
Poder U, Ljungman G, von Essen L (2010) Parents’ perceptions of their children’s cancer-related symptoms during treatment: a prospective, longitudinal study. J Pain Symptom Manag 40:661–670
Poe POES (2015) Supportive care and palliative medicine. The University of Texas MD Anderson Cancer Center
Pollono D, Tomarchia S, Drut R, Ibanez O, Ferreyra M, Cedola J (2003) Spinal cord compression: a review of 70 pediatric patients. Pediatr Hematol Oncol 20:457–466
Pui CH, Dahl GV, Hutsu HO, Murphy SB (1985) Epidural spinal cord compression as the initial finding in childhood acute leukemia and non-Hodgkin lymphoma. J Pediatr 106(5):788–192
Punt J, Pritchard J, Pincott JR, Till K (1980) Neuroblastoma: a review of 21 cases presenting with spinal cord compression. Cancer 45:3095–3101
Raffel C, Neave VC, Lavine S, Mccomb JG (1991) Treatment of spinal cord compression by epidural malignancy in childhood. Neurosurgery 28:349–352
Rando TA (1985) Bereaved parents: particular difficulties, unique factors, and treatment issues. Soc Work 30:19–23
Rheingold S, Lange B (2002) Oncologic emergencies. In: Pizzo PA, Poplack DG (eds) Principles and practices of pediatric oncology, 4th edn. Lippincott Williams and Wilkins, Philadelphia, PA
Ringner A, Jansson L, Graneheim UH (2011) Parental experiences of information within pediatric oncology. J Pediatr Oncol Nurs 28:244–251
Rodriguez M, Dinapoli RP (1980) Spinal cord compression: with special reference to metastatic epidural tumors. Mayo Clin Proc 55:442–448
Rosenberg AR, Baker KS, Syrjala K, Wolfe J (2012) Systematic review of psychosocial morbidities among bereaved parents of children with cancer. Pediatr Blood Cancer 58:503–512
Rubin S (1996) The wounded family: bereaved parents and the impact of adult child loss. In: Klass D, Silverman PR, Nickerman SL (eds) Continuing bonds: new understandings of grief. Taylor & Francis, Philadelphia, PA
Saunders C (1979–1980) A comparison of adult bereavement in the death of a spouse, child, and parent. Omega, 10, 302–322
Section on Hospice and Palliative Medicine and Committee on Hospital Care (2013) Section on hospice and palliative medicine and committee on hospital care: pediatric palliative care and hospice care commitments, guidelines, and recommendations
Shyn PB, Campbell GA, Guinto FC Jr, Crofford MJ (1986) Primary intracranial ependymoblastoma presenting as spinal cord compression due to metastasis. Childs Nerv Syst 2:323–325
Simon T, Niemann CA, Hero B, Henze G, Suttorp M, Schilling FH, Berthold F (2012) Short- and long-term outcome of patients with symptoms of spinal cord compression by neuroblastoma. Dev Med Child Neurol 54:347–352
Slevin ML, Stubbs L, Plant HJ, Wilson P, Gregory WM, Armes PJ, Downer SM (1990) Attitudes to chemotherapy: comparing views of patients with cancer with those of doctors, nurses, and general public. BMJ 300:1458–1460
Sloper P, While D (1996) Risk factors in the adjustment of siblings of children with cancer. J Child Psychol Psychiatry 37:597–607
Spettell CM, Rawlins WS, Krakauer R, Fernandes J, Breton ME, Gowdy W, Brodeur S, Maccoy M, Brennan TA (2009) A comprehensive case management program to improve palliative care. J Palliat Med 12:827–832
Steenland E, Leer JW, Van Houwelingen H, Post WJ, Van Den Hout WB, Kievit J, De Haes H, Martijn H, Oei B, Vonk E, Van Der Steen-Banasik E, Wiggenraad RG, Hoogenhout J, Warlam-Rodenhuis C, Van Tienhoven G, Wanders R, Pomp J, Van Reijn M, Van Mierlo I, Rutten E (1999) The effect of a single fraction compared to multiple fractions on painful bone metastases: a global analysis of the Dutch Bone Metastasis Study. Radiother Oncol 52:101–109
Stinson JN, Jibb LA, Nguyen C, Nathan PC, Maloney AM, Dupuis LL, Gerstle JT, Alman B, Hopyan S, Strahlendorf C, Portwine C, Johnston DL, Orr M (2013) Development and testing of a multidimensional iPhone pain assessment application for adolescents with cancer. J Med Internet Res 15:e51
Suki D, Khoury Abdulla R, Ding M, Khatua S, Sawaya R (2014) Brain metastases in patients diagnosed with a solid primary cancer during childhood: experience from a single referral cancer center. J Neurosurg Pediatr 14:372–385
Sulmasy DP, Cimino JE, He MK, Frishman WH (2008) U.S. medical students’ perceptions of the adequacy of their schools’ curricular attention to care at the end of life: 1998–2006. J Palliat Med 11:707–716
Tachdjian MO, Matson DD (1965) Orthopaedic aspects of intraspinal tumors in infants and children. J Bone Joint Surg Am 47:223–248
Theunissen JM, Hoogerbrugge PM, Van Achterberg T, Prins JB, Vernooij-Dassen MJ, Van Den Ende CH (2007) Symptoms in the palliative phase of children with cancer. Pediatr Blood Cancer 49:160–165
Trask CL, Welch JJ, Manley P, Jelalian E, Schwartz CL (2009) Parental needs for information related to neurocognitive late effects from pediatric cancer and its treatment. Pediatr Blood Cancer 52:273–279
Tucker TL, Samant RS, Fitzgibbon EJ (2010) Knowledge and utilization of palliative radiotherapy by pediatric oncologists. Curr Oncol 17:48–55
Vannucci RC, Baten M (1974) Cerebral metastatic disease in childhood. Neurology 24:981–985
Vern-Gross TZ (2013) Pediatric palliative radiation oncology. In: Lutz S, Chow E, Hoskin P (eds) Radiation oncology in palliative cancer care. Wiley, Chichester, UK, pp 220–234
Vern-Gross TZ, Lam CG, Graff Z, Singhal S, Levine DR, Gibson D, Sykes A, Anghelescu DL, Yuan Y, Baker JN (2015) Patterns of end-of-life care in children with advanced solid tumor malignancies enrolled on a palliative care service. J Pain Symptom Manag 50:305–312
Waldman E, Wolfe J (2013) Palliative care for children with cancer. Nat Rev Clin Oncol 10:100–107
Ward E, Desantis C, Robbins A, Kohler B, Jemal A (2014) Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin 64:83–103
Weeks JC, Cook EF, O’day SJ, Peterson LM, Wenger N, Reding D, Harrell FE, Kussin P, Dawson NV, Connors AF Jr, Lynn J, Phillips RS (1998) Relationship between cancer patients’ predictions of prognosis and their treatment preferences. JAMA 279:1709–1714
Widger K, Davies D, Drouin DJ, Beaune L, Daoust L, Farran RP, Humbert N, Nalewajek F, Rattray M, Rugg M, Bishop M (2007) Pediatric patients receiving palliative care in Canada: results of a multicenter review. Arch Pediatr Adolesc Med 161:597–602
Wiener L, Zadeh S, Wexler LH, Pao M (2013) When silence is not golden: Engaging adolescents and young adults in discussions around end-of-life care choices. Pediatr Blood Cancer 60:715–718
Wolfe J, Friebert S, Hilden J (2002) Caring for children with advanced cancer integrating palliative care. Pediatr Clin N Am 49:1043–1062
Wolfe J, Grier HE, Klar N, Levin SB, Ellenbogen JM, Salem-Schatz S, Emanuel EJ, Weeks JC (2000a) Symptoms and suffering at the end of life in children with cancer. N Engl J Med 342:326–333
Wolfe J, Hammel JF, Edwards KE, Duncan J, Comeau M, Breyer J, Aldridge SA, Grier HE, Berde C, Dussel V, Weeks JC (2008) Easing of suffering in children with cancer at the end of life: is care changing? J Clin Oncol 26:1717–1723
Wolfe J, Klar N, Grier HE, Duncan J, Salem-Schatz S, Emanuel EJ, Weeks JC (2000b) Understanding of prognosis among parents of children who died of cancer: impact on treatment goals and integration of palliative care. JAMA 284:2469–2475
Wolfe J, Orellana L, Ullrich C, Cook EF, Kang TI, Rosenberg A, Geyer R, Feudtner C, Dussel V (2015) Symptoms and distress in children with advanced cancer: prospective patient-reported outcomes from the PediQUEST study. J Clin Oncol 33:1928–1935
Worden J (1991) Grief counseling and greif therapy. Routledge, London
World Health Organization (2017) WHO definition of palliative care for children. http://www.who.int/cancer/palliative/definition/en/. Accessed 14 Sept 2017
Young B, Ward J, Salmon P, Gravenhorst K, Hill J, Eden T (2011) Parents’ experiences of their children’s presence in discussions with physicians about Leukemia. Pediatrics 127:e1230–e1238
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Vern-Gross, T., Marcus, K. (2018). Palliative Radiotherapy and Management of the Pediatric Oncology Patient. In: Merchant, T., Kortmann, RD. (eds) Pediatric Radiation Oncology. Pediatric Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-43545-9_20
Download citation
DOI: https://doi.org/10.1007/978-3-319-43545-9_20
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-43544-2
Online ISBN: 978-3-319-43545-9
eBook Packages: MedicineMedicine (R0)