Abstract
Since the beginning of radiology, its traditional goal was to provide images of the highest quality to allow the most accurate diagnoses [30]. This goal has changed. Clinical radiologists must now incorporate biological development and preclinical research into a clinical reality. The use of imaging measurements in individual patients improves the main clinical outcomes, such as depicting abnormalities, predicting prognosis, staging diseases, and defining follow-up outcomes. Radiologists may hereby engage patients and physicians into new approaches to facilitate decision-making for personalized care [12].
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References
Abramson RG, Su PF, Shyr Y. Quantitative metrics in clinical radiology reporting: a snapshot perspective from a single mixed academic-community practice. Magn Reson Imaging. 2012;30:1357–66.
Alberich-Bayarri A, Martí-Bonmatí L, Sanz-Requena R, Belloch E, Moratal D. In vivo trabecular bone morphologic and mechanical relationship using high-resolution 3-T MRI. AJR Am J Roentgenol. 2008;191:721–6.
Alberich-Bayarri A, Martí-Bonmatí L, Angeles Pérez M, Sanz-Requena R, Lerma-Garrido JJ, García-Martí G, Moratal D. Assessment of 2D and 3D fractal dimension measurements of trabecular bone from high-spatial resolution magnetic resonance images at 3 T. Med Phys. 2010;37:4930–7.
Ashton E. Quantitative MR, in multi-center clinical trials. J Magn Reson Imaging. 2010;31:279–88.
Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints. Clin Pharmacol Therap. 2001;69:89–95.
Buckler AJ, Bresolin L, Dunnick NR, et al. Quantitative imaging test approval and biomarker qualification: interrelated but distinct activities. Radiology. 2011;259:875–84.
Carlos RC, Buist DSM, Wernli KJ, et al. JACR 2012. Patient-centered outcomes in imaging: quantifying value. J Am Coll Radiol. 2012;9:725–8.
Durá E, Domingo J, Ayala G, Martí-Bonmatí L. Evaluation of the registration of temporal series of contrast-enhanced perfusion magnetic resonance 3D images of the liver. Comput Methods Programs Biomed. 2012;108:932–45.
European Society of Radiology Working Group on Imaging Biomarkers, van Beers B, Cuenod CA, Martí-Bonmatí L, Matos C, Niessen W, Padhani A. White paper on imaging biomarkers. Insights Imaging. 2010;1:42–5.
Gillies RJ, Kinahan PE, Hricak H. Radiomics: images are more than pictures, they are data. Radiology. 2015;18:151169.
Herold CJ, Lewin JS, Wibmer AG, et al. Imaging in the age of precision medicine: summary of the proceedings of the 10th Biannual Symposium of the International Society for Strategic Studies in Radiology. Radiology. 2016;279(1):226–38.
Kang SK, Fagerlin A, Braithwaite RS. A roadmap for personalized care in radiology. Radiology. 2015;277:638–43.
Krishnaraj A, Weinreb JC, Ellenbogen PH, Allen Jr B, Norbash A, Kazerooni EA. The future of imaging biomarkers in radiologic practice: proceedings of the thirteenth annual ACR Forum. J Am Coll Radiol. 2014;11:20–3.
Kurlanda BF, Gerstnerb ER, Mountzc JM. Promise and pitfalls of quantitative imaging in oncology clinical trials. Magn Reson Imaging. 2012;30:1301–12.
Kumar V, Gu Y, Basu S, et al. Radiomics: the process and the challenges. Magn Reson Imaging. 2012;30:1234–48.
Lee CI, Forman HP. What we can and cannot see coming. Radiology. 2010;257:313–4.
Manjón JV, Lull JJ, Carbonell-Caballero J, García-Martí G, Martí-Bonmatí L, Robles M. A nonparametric MRI inhomogeneity correction method. Med Image Anal. 2007;11:336–45.
Manjón JV, Coupé P, Martí-Bonmatí L, Collins DL, Robles M. Adaptive non-local means denoising of MR images with spatially varying noise levels. J Magn Reson Imaging. 2010;31:192–203.
Martí-Bonmatí L, José Lull JJ, García-Martí G, et al. MR analysis of the coincidence between functional and morphological abnormalities in schizophrenic patients with chronic auditory hallucinations. Radiology. 2007;244:549–56.
Martí-Bonmatí L, Sanz-Requena R, Alberich-Bayarri A. Pharmacokinetic MR analysis of the cartilage is influenced by field strength. Eur J Radiol. 2008;67:448–52.
Martí-Bonmatí L, Alberich-Bayarri A, Sánchez-González J. Overload hepatitides: quanti-qualitative analysis. Abdom Imaging. 2012;37:180–7.
Martí-Bonmatí L, Alberich-Bayarri A, García-Martí G, et al. Imaging biomarkers, quantitative imaging, and bioengineering. Radiologia. 2012;54:269–78.
Nilsen LB, Fangberget A, Geier OM, Engebraaten O, Borgen E, Olsen DR, Seierstad T. Associations between tumor vascularization assessed by in vivo DCE-MRI and the presence of disseminated tumor cells in bone marrow in breast cancer patients at the time of diagnosis. J Magn Reson Imaging. 2014;40(6):1382–91.
Pomar-Nadal A, Pérez-Castillo C, Alberich-Bayarri A, García-Martí G, Sanz-Requena R, Martí-Bonmatí L. Integrating information about imaging biomarkers into structured radiology reports. Radiologia. 2013;55:188–94.
Sanz-Requena R, Revert-Ventura A, Martí-Bonmatí L, Alberich-Bayarri A, García-Martí G. Quantitative MR perfusion parameters related to survival time in high-grade gliomas. Eur Radiol. 2013;23:3456–65.
Schuster DP. The opportunities and challenges of developing imaging biomarkers to study lung function and disease. Am J Respir Crit Care Med. 2007;176:224–30.
Smith JJ, Sorensen AG, Thrall JH. Biomarkers in imaging: realizing radiology’s future. Radiology. 2003;227:633–8.
Sullivan DC. Imaging as a quantitative science. Radiology. 2008;248:328–32.
Sullivan DC, Obuchowski NA, Kessler LG, et al. Metrology standards for quantitative imaging biomarkers. Radiology. 2015;277:813–25.
Thornbury JR. Clinical efficacy of diagnostic imaging: love it or leave it. AJR Am J Roentgenol. 1994;162:1–8.
Tofts PS, Collins DJ. Multicentre imaging measurements for oncology and in the brain. Br J Radiol. 2011;84 Spec No 2:S213–26.
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Martí-Bonmatí, L. (2017). Introduction to the Stepwise Development of Imaging Biomarkers. In: Martí-Bonmatí, L., Alberich-Bayarri, A. (eds) Imaging Biomarkers. Springer, Cham. https://doi.org/10.1007/978-3-319-43504-6_2
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