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Sunlight-Induced DNA Damage: Molecular Mechanisms and Photoprotection Strategies

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Skin Stress Response Pathways

Abstract

Epidemiological and biological studies point DNA damage as a major event in the induction of skin cancers. It is thus important to determine the nature of these DNA lesions and their main biological features like repair and mutagenicity. Available data allowed to identify pyrimidine dimers as the main carcinogenic class of DNA damage, with oxidative stress also playing a role to a lesser extent. Such information is important in order to design and evaluate appropriate photoprotective strategies. The present chapter summarizes the main data available on the formation of DNA damage caused by solar UV radiation. The repair and mutagenic properties of the different lesions are then compared in order to determine the most carcinogenic photo-induced mechanisms. Based on these data, a critical review of the main photoprotection approaches is proposed.

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  1. University of Grenoble Alpes, INAC, LCIB, LAN, 38000, Grenoble, France

    Thierry Douki

  2. CEA, INAC, SCIB, LAN, 38000, Grenoble, France

    Thierry Douki

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  1. Department of Pharmacology and Toxicology, College of Pharmacy & The University of Arizona Cancer Center, Department of Pharmacology and Toxicology, TUCSON, Arizona, USA

    Georg T. Wondrak

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Douki, T. (2016). Sunlight-Induced DNA Damage: Molecular Mechanisms and Photoprotection Strategies. In: Wondrak, G. (eds) Skin Stress Response Pathways. Springer, Cham. https://doi.org/10.1007/978-3-319-43157-4_3

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