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Scabies

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Neglected Tropical Diseases - Oceania

Part of the book series: Neglected Tropical Diseases ((NTD))

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Abstract

Challenges for the control of scabies in Oceania include the requirement for combining public health and biomedical strategies. There is a critical need for more baseline epidemiological information, and sustained improvements will not occur without addressing the primordial development issues of housing, sanitation, hygiene, nutrition, education, and maternal health. Recent studies from Fiji provide optimism for the future, including a large mass drug administration program showing oral ivermectin to have superior effectiveness in comparison to topical permethrin. This will help form the basis of a more coordinated approach to scabies as a neglected tropical disease with global visibility. Lessons from development of control programs for other neglected tropical diseases will also help optimize both scabies-specific strategies and their coordination with and integration into existing clinical and public health programs. The importance of scabies as a driver of high rates of bacterial skin infections and their sequelae is well recognized. Ongoing applied biomedical research is directed at better understanding the immunological responses to scabies infection, development of better and more specific diagnostics including direct mite detection and serological assays, vaccine development, and understanding the complex immunopathogenetic interactions between scabies mites and skin bacteria such as streptococci and staphylococci.

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References

  • Adjei O, Brenya RC (1997) Secondary bacterial infection in Ghanaian patients with scabies. East Afr Med J 74:729–731

    CAS  PubMed  Google Scholar 

  • Alasaad S, Walton S, Rossi L, Bornstein S, Abu-Madi M, Soriguer RC, Fitzgerald S, Zhu XQ, Zimmermann W, Ugbomoiko US, Pei KJ, Heukelbach J, Sarcoptes-World Molecular N (2011) Sarcoptes-World Molecular Network (Sarcoptes-WMN): integrating research on scabies. Int J Infect Dis 15:e294–e297

    Article  PubMed  Google Scholar 

  • Alasaad S, Sarasa M, Heukelbach J, Mijele D, Soriguer RC, Zhu XQ, Rossi L (2014) Advances in studies of disease-navigating webs: Sarcoptes scabiei as a case study. Parasit Vectors 7:16

    Article  PubMed  PubMed Central  Google Scholar 

  • Andersen LK, Davis MD (2015) The effects of the El Nino Southern Oscillation on skin and skin-related diseases: a message from the International Society of Dermatology Climate Change Task Force. Int J Dermatol 54:1343–1351

    Article  PubMed  Google Scholar 

  • Andersen LK, Hercogová J, Wollina U, Davis MDP (2012) Climate change and skin disease: a review of the English-language literature. Int J Dermatol 51:656–661

    Article  PubMed  Google Scholar 

  • Andrews JRH, Tonkin SL (1989) Scabies and pediculosis in Tokelau Island children in New Zealand. J R Soc Health 109:199–203

    Article  CAS  PubMed  Google Scholar 

  • Andrews RM, McCarthy J, Carapetis JR, Currie BJ (2009a) Skin disorders, including pyoderma, scabies, and tinea infections. Pediatr Clin North Am 56:1421–1440

    Article  PubMed  Google Scholar 

  • Andrews RM, Kearns T, Connors C, Parker C, Carville K, Currie BJ, Carapetis JR (2009b) A regional initiative to reduce skin infections amongst aboriginal children living in remote communities of the Northern Territory, Australia. PLoS Negl Trop Dis 3:e554

    Article  PubMed  PubMed Central  Google Scholar 

  • Arlian LG, Vyszenski-Moher DL (1988) Life cycle of Sarcoptes scabiei var canis. J Parasitol 74:427–430

    Article  CAS  PubMed  Google Scholar 

  • Arlian LG, Runyan RA, Estes SA (1984a) Cross infectivity of Sarcoptes scabiei. J Am Acad Dermatol 10:979–986

    Article  CAS  PubMed  Google Scholar 

  • Arlian LG, Runyan RA, Sorlie LB, Estes SA (1984b) Host-seeking behaviour of Sarcoptes scabiei. J Am Acad Dermatol 11:594–598

    Article  CAS  PubMed  Google Scholar 

  • Arlian LG, Runyan RA, Achar S, Estes SA (1984c) Survival and infectivity of Sarcoptes scabiei var. canis and var. hominis. J Am Acad Dermatol 11:210–215

    Article  CAS  PubMed  Google Scholar 

  • Arlian LG, Runyan RA, Sorlie LB, Vyszenski-Moher DL, Estes SA (1985) Characterization of Sarcoptes scabiei var. canis (Acari: Sarcoptidae) antigens and induced antibodies in rabbits. J Med Entomol 22:321–323

    Article  CAS  PubMed  Google Scholar 

  • Arlian LG, Vyszenski-Moher DL, Cordova D (1988a) Host specificity of S. scabiei var. canis (Acari: Sarcoptidae) and the role of host odour. J Med Entomol 25:52–56

    Article  CAS  PubMed  Google Scholar 

  • Arlian LG, Estes SA, Vyszenski-Moher DL (1988b) Prevalence of Sarcoptes scabiei in the homes and nursing homes of scabietic patients. J Am Acad Dermatol 19:806–811

    Article  CAS  PubMed  Google Scholar 

  • Arlian LG, Rapp CM, Stemmer BL, Morgan MS, Moore PF (1997) Characterization of lymphocyte subtypes in scabietic skin lesions of naive and sensitized dogs. Vet Parasitol 68:347–358

    Article  CAS  PubMed  Google Scholar 

  • Arlian LG, Morgan MS, Estes SA, Walton SF, Kemp DJ, Currie BJ (2004) Circulating IgE in patients with ordinary and crusted scabies. J Med Entomol 41:74–77

    Article  PubMed  Google Scholar 

  • Arlian LG, Feldmeier H, Morgan MS (2015) The potential for a blood test for scabies. PLoS Negl Trop Dis 9:e0004188

    Article  PubMed  PubMed Central  Google Scholar 

  • Bailie RS, Stevens MR, McDonald E, Halpin S, Brewster D, Robinson G, Guthridge S (2005) Skin infection, housing and social circumstances in children living in remote Indigenous communities: testing conceptual and methodological approaches. BMC Public Health 5:128

    Article  PubMed  PubMed Central  Google Scholar 

  • Barkwell R, Shields S (1997) Deaths associated with ivermectin treatment of scabies. Lancet 349:1144–1145

    Article  CAS  PubMed  Google Scholar 

  • Bates M, Zumla A (2015) Rapid infectious diseases diagnostics using Smartphones. Ann Transl Med 3:215

    PubMed  PubMed Central  Google Scholar 

  • Beckham SA, Boyd SE, Reynolds S, Willis C, Johnstone M, Mika A, Simerska P, Wijeyewickrema LC, Smith AI, Kemp DJ, Pike RN, Fischer K (2009) Characterization of a serine protease homologous to house dust mite group 3 allergens from the scabies mite Sarcoptes scabiei. J Biol Chem 284:34413–34422

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bergstrom FC, Reynolds S, Johnstone M, Pike RN, Buckle AM, Kemp DJ, Fischer K, Blom AM (2009) Scabies mite inactivated serine protease paralogs inhibit the human complement system. J Immunol 182:7809–7817

    Article  PubMed  Google Scholar 

  • Bowen AC, Tong SYC, Chatfield MD, Carapetis JR (2014) The microbiology of impetigo in Indigenous children: associations between, scabies, and nasal carriage. BMC Infect Dis 14:727

    Article  PubMed  PubMed Central  Google Scholar 

  • Bowen AC, Mahe A, Hay RJ, Andrews RM, Steer AC, Tong SY, Carapetis JR (2015) The global epidemiology of impetigo: a systematic review of the population prevalence of impetigo and pyoderma. PLoS One 10:e0136789

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Boyd R, Patel M, Currie BJ, Holt DC, Harris T, Krause V (2016) High burden of invasive group A streptococcal disease in the Northern Territory of Australia. Epidemiol Infect 144:1018–1027

    Article  CAS  PubMed  Google Scholar 

  • Buczek A, Pabis B, Bartosik K, Stanislawek IM, Salata M, Pabis A (2006) Epidemiological study of scabies in different environmental conditions in central poland. Ann Epidemiol 16:423–428

    Article  PubMed  Google Scholar 

  • Cai Y, Shen X, Ding C, Qi C, Li K, Li X, Jala VR, Zhang HG, Wang T, Zheng J, Yan J (2011) Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation. Immunity 35:596–610

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Carapetis JR, Currie BJ (2001) Rheumatic fever in a high incidence population: the importance of monoarthritis and low grade fever. Arch Dis Child 85:223–227

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Carapetis JR, Connors C, Yarmirr D, Krause V, Currie BJ (1997) Success of a scabies control program in an Australian aboriginal community. Pediatr Infect Dis J 16:494–499

    Article  CAS  PubMed  Google Scholar 

  • Carapetis JR, Currie BJ, Kaplan EL (1999) Epidemiology and prevention of group A streptococcal infections: acute respiratory tract infections, skin infections, and their sequelae at the close of the twentieth century. Clin Infect Dis 28:205–210

    Article  CAS  PubMed  Google Scholar 

  • Casais R, Dalton KP, Millan J, Balseiro A, Oleaga A, Solano P, Goyache F, Prieto JM, Parra F (2014) Primary and secondary experimental infestation of rabbits (Oryctolagus cuniculus) with Sarcoptes scabiei from a wild rabbit: factors determining resistance to reinfestation. Vet Parasitol 203:173–183

    Article  PubMed  Google Scholar 

  • Chosidow O (2006) Clinical practices. Scabies. N Engl J Med 354:1718–1727

    Article  CAS  PubMed  Google Scholar 

  • Clucas D (2006) Burden of scabies and skin sores among children in remote East Arnhem Aboriginal communities of the Northern Territory Department of Paediatrics. University of Melbourne, Melbourne

    Google Scholar 

  • Clucas DB, Carville KS, Connors C, Currie BJ, Carapetis JR, Andrews RM (2008) Disease burden and health-care clinic attendances for young children in remote Aboriginal communities of northern Australia. Bull World Health Organ 86:275–281

    Article  PubMed  PubMed Central  Google Scholar 

  • Craven J, Bjorn H, Hennessy DR, Friis C (2002) The effects of body composition on the pharmacokinetics of subcutaneously injected ivermectin and moxidectin in pigs. J Vet Pharmacol Ther 25:227–232

    Article  CAS  PubMed  Google Scholar 

  • Currie BJ (2015) Scabies and global control of neglected tropical diseases. N Engl J Med 373:2371–2372

    Article  CAS  PubMed  Google Scholar 

  • Currie BJ, Carapetis JR (2000) Skin infections and infestations in Aboriginal communities in northern Australia. Aust J Dermatol 41:139–145

    Article  CAS  Google Scholar 

  • Currie BJ, McCarthy JS (2010) Permethrin and ivermectin for scabies. N Engl J Med 362:717–725

    Article  CAS  PubMed  Google Scholar 

  • Currie BJ, Connors CM, Krause VL (1994) Scabies programs in aboriginal communities. Med J Aust 161:636–637

    CAS  PubMed  Google Scholar 

  • Currie BJ, Maguire GP, Wood YK (1995) Ivermectin and crusted (Norwegian) scabies. Med J Aust 163:559–560

    CAS  PubMed  Google Scholar 

  • Currie BJ, Harumal P, McKinnon M, Walton SF (2004) First documentation of in vivo and in vitro ivermectin resistance in Sarcoptes scabiei. Clin Infect Dis 39:e8–e12

    Article  CAS  PubMed  Google Scholar 

  • Davis JS, McGloughlin S, Tong SY, Walton SF, Currie BJ (2013) A novel clinical grading scale to guide the management of crusted scabies. PLoS Negl Trop Dis 7:e2387

    Article  PubMed  PubMed Central  Google Scholar 

  • del Mar Saez-De-Ocariz M, McKinster CD, Orozco-Covarrubias L, Tamayo-Sanchez L, Ruiz-Maldonado R (2002) Treatment of 18 children with scabies or cutaneous larva migrans using ivermectin. Clin Exp Dermatol 27:264–267

    Article  CAS  PubMed  Google Scholar 

  • Dougall A, Holt DC, Fischer K, Currie BJ, Kemp DJ, Walton SF (2005) Identification and characterization of Sarcoptes scabiei and Dermatophagoides pteronyssinus glutathione S-transferases: implication as a potential major allergen in crusted scabies. Am J Trop Med Hyg 73:977–984

    CAS  PubMed  Google Scholar 

  • Dyring-Andersen B, Bonefeld CM, Bzorek M, Lovendorf MB, Lauritsen JP, Skov L, Geisler C, The Vitamin D (2015) Analogue calcipotriol reduces the frequency of CD8+ IL-17+ T cells in psoriasis lesions. Scand J Immunol 82:84–91

    Article  CAS  PubMed  Google Scholar 

  • Edison L, Beaudoin A, Goh L, Introcaso CE, Martin D, Dubray C, Marrone J, Van Beneden C (2015) Scabies and Bacterial Superinfection among American Samoan Children, 2011–2012. PLoS One 10:e0139336

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Engelman D, Kiang K, Chosidow O, McCarthy J, Fuller C, Lammie P, Hay R, Steer A, Members of the International Alliance for the Control of S (2013) Toward the global control of human scabies: introducing the International Alliance for the Control of Scabies. PLoS Negl Trop Dis 7:e2167

    Google Scholar 

  • Feldmeier H, Chhatwal GS, Guerra H (2005) Editorial: Pyoderma, group A streptococci and parasitic skin diseases – a dangerous relationship. Trop Med Int Health 10:713–716

    Article  PubMed  Google Scholar 

  • Feldmeier H, Jackson A, Ariza L, Lins Calheiros CM, de Lima Soares V, Oliveira FA, Hengge UR, Heukelbach J (2009) The epidemiology of scabies in an impoverished community in rural Brazil: presence and severity of disease are associated with poor living conditions and illiteracy. J Am Acad Dermatol 60:436–443

    Article  PubMed  Google Scholar 

  • Fischer K, Walton S (2014) Parasitic mites of medical and veterinary importance – is there a common research agenda? Int J Parasitol 44:955–967

    Article  PubMed  Google Scholar 

  • Fischer K, Holt DC, Harumal P, Currie BJ, Walton SF, Kemp DJ (2003) Generation and characterization of cDNA clones from Sarcoptes scabiei var. hominis for an expressed sequence tag library: identification of homologues of house dust mite allergens. Am J Trop Med Hyg 68:61–64

    CAS  PubMed  Google Scholar 

  • Gray S, Lennon D, Anderson P, Stewart J, Farrell E (2013) Nurse-led school-based clinics for skin infections and rheumatic fever prevention: results from a pilot study in South Auckland. N Z Med J 126:53–61

    PubMed  Google Scholar 

  • Gu X, Xie Y, Wang S, Peng X, Lai S, Yang G (2014) Immune response induced by candidate Sarcoptes scabiei var. cuniculi DNA vaccine encoding paramyosin in mice. Exp Appl Acarol 63:401–412

    Article  CAS  PubMed  Google Scholar 

  • Guzzo CA, Furtek CI, Porras AG, Chen C, Tipping R, Clineschmidt CM, Sciberras DG, Hsieh JY, Lasseter KC (2002) Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects. J Clin Pharmacol 42:1122–1133

    Article  CAS  PubMed  Google Scholar 

  • Gyapong JO, Chinbuah MA, Gyapong M (2003) Inadvertent exposure of pregnant women to ivermectin and albendazole during mass drug administration for lymphatic filariasis. Trop Med Int Health 8:1093–1101

    Article  CAS  PubMed  Google Scholar 

  • Haar K, Romani L, Filimone R, Kishore K, Tuicakau M, Koroivueta J, Kaldor JM, Wand H, Steer A, Whitfeld M (2014) Scabies community prevalence and mass drug administration in two Fijian villages. Int J Dermatol 53:739–745

    Article  PubMed  Google Scholar 

  • Hales BJ, Laing IA, Pearce LJ, Hazell LA, Mills KL, Chua KY, Thornton RB, Richmond P, Musk AW, James AL, Lesouef PN, Thomas WR (2007) Distinctive immunoglobulin E anti-house dust allergen-binding specificities in a tropical Australian Aboriginal community. Clin Exp Allergy 37:1357–1363

    Article  CAS  PubMed  Google Scholar 

  • Harris M, Nako D, Hopkins T, Powell DM, Kenny C, Carroll C, Carroll K (1992) Skin infections in Tanna, Vanuatu in 1989. P N G Med J 35:137–143

    CAS  PubMed  Google Scholar 

  • Hay R, Steer A, Engelman D, Walton S (2012) Scabies in the developing world—its prevalence, complications, and management. Clin Microbiol Infect 18:313–323

    Article  CAS  PubMed  Google Scholar 

  • Hay RJ, Steer AC, Chosidow O, Currie BJ (2013) Scabies: a suitable case for a global control initiative. Curr Opin Infect Dis 26:107–109

    Article  PubMed  Google Scholar 

  • Hay RJ, Johns NE, Williams HC, Bolliger IW, Dellavalle RP, Margolis DJ, Marks R, Naldi L, Weinstock MA, Wulf SK, Michaud C, Murray CJL, Naghavi M (2014) The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions. J Invest Dermatol 134:1527–1534

    Article  CAS  PubMed  Google Scholar 

  • Hengge UR, Currie BJ, Jäger G, Lupi O, Schwartz RA (2006) Scabies: a ubiquitous neglected skin disease. Lancet Infect Dis 6:769–779

    Article  PubMed  Google Scholar 

  • Heukelbach J, Mazigo HD, Ugbomoiko US (2013) Impact of scabies in resource-poor communities. Curr Opin Infect Dis 26:127–132

    Article  PubMed  Google Scholar 

  • Hewitt KA, Nalabanda A, Cassell JA (2015) Scabies outbreaks in residential care homes: factors associated with late recognition, burden and impact. A mixed methods study in England. Epidemiol Infect 143:1542–1551

    Article  CAS  PubMed  Google Scholar 

  • Holt DC, Fischer K, Pizzutto SJ, Currie BJ, Walton SF, Kemp DJ (2004) A multigene family of inactivated cysteine proteases in Sarcoptes scabiei. J Invest Dermatol 123:240–241

    Article  CAS  PubMed  Google Scholar 

  • Holt DC, Burgess ST, Reynolds SL, Mahmood W, Fischer K (2013) Intestinal proteases of free-living and parasitic astigmatid mites. Cell Tissue Res 351:339–352

    Article  CAS  PubMed  Google Scholar 

  • Jayaraj R, Hales B, Viberg L, Pizzuto S, Holt D, Rolland JM, O’Hehir RE, Currie BJ, Walton SF (2011) A diagnostic test for scabies: IgE specificity for a recombinant allergen of Sarcoptes scabiei. Diagn Microbiol Infect Dis 71:403–407

    Article  CAS  PubMed  Google Scholar 

  • Jin-gang A, Sheng-xiang X, Sheng-bin X, Jun-min W, Song-mei G, Ying-ying D, Jung-hong M, Qing-qiang X, Xiao-peng W (2010) Quality of life of patients with scabies. J Eur Acad Dermatol Venereol 24:1187–1191

    Article  CAS  PubMed  Google Scholar 

  • Jungbauer FH, Veenstra-Kyuchukova YK, Koeze J, KruijtSpanjer MR, Kardaun SH (2015) Management of nosocomial scabies, an outbreak of occupational disease. Am J Ind Med 58:577–582

    Article  PubMed  Google Scholar 

  • Kearns T, Clucas D, Connors C, Currie BJ, Carapetis JR, Andrews RM (2013) Clinic attendances during the first 12 months of life for Aboriginal children in five remote communities of northern Australia. PLoS One 8:e58231

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kim R, Costello A, Campbell-Lendrum D (2015) Climate change and health in Pacific island states. Bull World Health Organ 93:819

    Article  PubMed  PubMed Central  Google Scholar 

  • La Vincente S, Kearns T, Connors C, Cameron S, Carapetis J, Andrews R (2009) Community management of endemic scabies in remote aboriginal communities of northern Australia: low treatment uptake and high ongoing acquisition. PLoS Negl Trop Dis 3:e444

    Article  PubMed  PubMed Central  Google Scholar 

  • Landwehr D, Keita SM, Pönnighaus JM, Tounkara C (1998) Epidemiologic aspects of scabies in Mali, Malawi, and Cambodia. Int J Dermatol 37:588–590

    Article  CAS  PubMed  Google Scholar 

  • Lines DR (1977) An Auckland high school health survey. Aust N Z J Med 7:143–147

    Article  CAS  PubMed  Google Scholar 

  • Liu X, Walton SF, Murray HC, King M, Kelly A, Holt DC, Currie BJ, McCarthy JS, Mounsey KE (2014a) Crusted scabies is associated with increased IL-17 secretion by skin T cells. Parasite Immunol 36:594–604

    Article  CAS  PubMed  Google Scholar 

  • Liu X, Walton S, Mounsey K (2014b) Vaccine against scabies: necessity and possibility. Parasitology 141:725–732

    Article  PubMed  Google Scholar 

  • Lokuge B, Kopczynski A, Woltmann A, Alvoen F, Connors C, Guyula T, Mulholland E, Cran S, Foster T, Lokuge K, Burke T, Prince S (2014) Crusted scabies in remote Australia, a new way forward: lessons and outcomes from the East Arnhem Scabies Control Program. Med J Aust 200:644–648

    Article  PubMed  Google Scholar 

  • Ly F, Caumes E, Ndaw CA, Ndiaye B, Mahe A (2009) Ivermectin versus benzyl benzoate applied once or twice to treat human scabies in Dakar, Senegal: a randomized controlled trial. Bull World Health Organ 87:424–430

    Article  PubMed  PubMed Central  Google Scholar 

  • Mahe A, Faye O, N’Diaye HT, Ly F, Konare H, Keita S, Traore AK, Hay R (2005) Definition of an algorithm for the management of common skin diseases at primary health care level in sub-Saharan Africa. Trans R Soc Trop Med Hyg 99:39–47

    Article  CAS  PubMed  Google Scholar 

  • Mahmood W, Viberg LT, Fischer K, Walton SF, Holt DC (2013) An aspartic protease of the scabies mite Sarcoptes scabiei is involved in the digestion of host skin and blood macromolecules. PLoS Negl Trop Dis 7:e2525

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Marquardt T (2014) Managing skin infections in Aboriginal and Torres Strait Islander children. Aust Fam Physician 43:16–19

    PubMed  Google Scholar 

  • Marshall CS, Cheng AC, Markey PG, Towers RJ, Richardson LJ, Fagan PK, Scott L, Krause VL, Currie BJ (2011) Acute post-streptococcal glomerulonephritis in the Northern Territory of Australia: a review of 16 years data and comparison with the literature. Am J Trop Med Hyg 85:703–710

    Article  PubMed  PubMed Central  Google Scholar 

  • McMeniman E, Holden L, Kearns T, Clucas DB, Carapetis JR, Currie BJ, Connors C, Andrews RM (2011) Skin disease in the first two years of life in Aboriginal children in East Arnhem Land. Aust J Dermatol 52:270–273

    Article  Google Scholar 

  • McMichael AJ (2013) Globalization, climate change, and human health. N Engl J Med 368:1335–1343

    Article  CAS  PubMed  Google Scholar 

  • Mellanby K (1944a) The development of symptoms, parasitic infection and immunity in human scabies. Parasitology 35:197–206

    Article  Google Scholar 

  • Mellanby K (1944b) The development of symptoms, parasitic infection and immunity in human scabies. Parasitology 35:197–206

    Article  Google Scholar 

  • Mika A, Goh P, Holt DC, Kemp DJ, Fischer K (2011) Scabies mite peritrophins are potential targets of human host innate immunity. PLoS Negl Trop Dis 5:e1331

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mika A, Reynolds SL, Mohlin FC, Willis C, Swe PM, Pickering DA, Halilovic V, Wijeyewickrema LC, Pike RN, Blom AM, Kemp DJ, Fischer K (2012a) Novel scabies mite serpins inhibit the three pathways of the human complement system. PLoS One 7:e40489

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mika A, Reynolds SL, Pickering D, McMillan D, Sriprakash KS, Kemp DJ, Fischer K (2012b) Complement inhibitors from scabies mites promote streptococcal growth – a novel mechanism in infected epidermis? PLoS Negl Trop Dis 6:e1563

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mounsey KE, Holt DC, McCarthy J, Walton SF (2006) Identification of ABC transporters in Sarcoptes scabiei. Parasitology 132:883–892

    Article  CAS  PubMed  Google Scholar 

  • Mounsey KE, Holt DC, McCarthy J, Currie BJ, Walton SF (2008) Scabies: molecular perspectives and therapeutic implications in the face of emerging drug resistance. Future Microbiol 3:57–66

    Article  CAS  PubMed  Google Scholar 

  • Mounsey KE, Holt DC, McCarthy JS, Currie BJ, Walton SF (2009) Longitudinal evidence of increasing in vitro tolerance of scabies mites to ivermectin in scabies-endemic communities. Arch Dermatol 145:840–841

    Article  PubMed  Google Scholar 

  • Mounsey K, Ho MF, Kelly A, Willis C, Pasay C, Kemp DJ, McCarthy JS, Fischer K (2010) A tractable experimental model for study of human and animal scabies. PLoS Negl Trop Dis 4:e756

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mounsey KE, McCarthy JS, Walton SF (2013) Scratching the itch: new tools to advance understanding of scabies. Trends Parasitol 29:35–42

    Article  PubMed  Google Scholar 

  • Mounsey KE, Murray HC, Bielefeldt-Ohmann H, Pasay C, Holt DC, Currie BJ, Walton SF, McCarthy JS (2015) Prospective study in a porcine model of sarcoptes scabiei indicates the association of Th2 and Th17 pathways with the clinical severity of scabies. PLoS Negl Trop Dis 9:e0003498

    Article  PubMed  PubMed Central  Google Scholar 

  • Naz S, Rizvi DA, Javaid A, Ismail M, Chaudhry FR (2013) Validation of PCR Assay for Identification of Sarcoptes scabiei var. hominis. Iran J Parasitol 8:437–440

    PubMed  PubMed Central  Google Scholar 

  • Nishimoto S, Kotani H, Tsuruta S, Shimizu N, Ito M, Shichita T, Morita R, Takahashi H, Amagai M, Yoshimura A (2013) Th17 cells carrying TCR recognizing epidermal autoantigen induce psoriasis-like skin inflammation. J Immunol 191:3065–3072

    Article  CAS  PubMed  Google Scholar 

  • O’Sullivan C, Baker MG (2012) Skin infections in children in a New Zealand primary care setting: exploring beneath the tip of the iceberg. N Z Med J 125:70–79

    PubMed  Google Scholar 

  • Oleaga A, Alasaad S, Rossi L, Casais R, Vicente J, Maione S, Soriguer RC, Gortazar C (2013) Genetic epidemiology of Sarcoptes scabiei in the Iberian wolf in Asturias, Spain. Vet Parasitol 196:453–459

    Article  PubMed  Google Scholar 

  • World Health Organisation (2005) Epidemiology and management of common skin diseases in children in developing countries. World Health Organisation, Geneva

    Google Scholar 

  • Pasay C, Arlian L, Morgan M, Gunning R, Rossiter L, Holt D, Walton S, Beckham S, McCarthy J (2009) The effect of insecticide synergists on the response of scabies mites to pyrethroid acaricides. PLoS Negl Trop Dis 3:e354

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Prichard RK (2007) Ivermectin resistance and overview of the Consortium for Anthelmintic Resistance SNPs. Expert Opin Drug Discovery 2:S41–S52

    Article  CAS  Google Scholar 

  • Rampton M, Walton SF, Holt DC, Pasay C, Kelly A, Currie BJ, McCarthy JS, Mounsey KE (2013) Antibody responses to Sarcoptes scabiei apolipoprotein in a porcine model: relevance to immunodiagnosis of recent infection. PLoS One 8:e65354

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rapp CM, Morgan MS, Arlian LG (2006) Presence of host immunoglobulin in the gut of Sarcoptes scabiei (Acari: Sarcoptidae). J Med Entomol 43:539–542

    Article  CAS  PubMed  Google Scholar 

  • Roberts LJ, Huffam SE, Walton SF, Currie BJ (2005) Crusted scabies: clinical and immunological findings in seventy-eight patients and a review of the literature. J Infect 50:375–381

    Article  CAS  PubMed  Google Scholar 

  • Romani L, Koroivueta J, Steer AC, Kama M, Kaldor JM, Wand H, Hamid M, Whitfeld MJ (2015a) Scabies and impetigo prevalence and risk factors in Fiji: a national survey. PLoS Negl Trop Dis 9:e0003452

    Article  PubMed  PubMed Central  Google Scholar 

  • Romani L, Steer AC, Whitfeld MJ, Kaldor JM (2015b) Prevalence of scabies and impetigo worldwide: a systematic review. Lancet Infect Dis 15:960–967

    Article  PubMed  Google Scholar 

  • Romani L, Steer AC, Whitfeld MJ, Kaldor JM (2015c) Prevalence of scabies and impetigo worldwide: a systematic review. Lancet Infect Dis 15:960–967

    Article  PubMed  Google Scholar 

  • Romani L, Whitfeld MJ, Koroivueta J, Kama M, Wand HB, Tikoduadua L, Tuicakau M, Koroi A, Andrews R, Kaldor JM, Steer AC (2015d) Mass drug administration for scabies control in a population with endemic disease. N Engl J Med 373:2305–2313

    Article  CAS  PubMed  Google Scholar 

  • Rutitzky LI, Lopes da Rosa JR, Stadecker MJ (2005) Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17. J Immunol 175:3920–3926

    Article  CAS  PubMed  Google Scholar 

  • Schaible UE, Kaufmann SH (2007) Malnutrition and infection: complex mechanisms and global impacts. PLoS Med 4:e115

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sfeir M, Munoz-Price LS (2014) Scabies and bedbugs in hospital outbreaks. Curr Infect Dis Rep 16:412

    Article  PubMed  Google Scholar 

  • Sharma RS, Mishra RS, Pal D, Gupta JP, Dutta M, Datta KK (1984) An epidemiological study of scabies in a rural community in India. Ann Trop Med Parasitol 78:157–164

    Article  CAS  PubMed  Google Scholar 

  • Steer AC, Adams J, Carlin J, Nolan T, Shann F (1999) Rheumatic heart disease in school children in Samoa. Arch Dis Child 81:372

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Steer AC, Jenney AWJ, Kado J, Batzloff MR, La Vincente S, Waqatakirewa L, Mulholland EK, Carapetis JR (2009a) High burden of impetigo and scabies in a tropical country. PLoS Negl Trop Dis 3(6):e467

    Article  PubMed  PubMed Central  Google Scholar 

  • Steer AC, Tikoduadua LV, Manalac EM, Colquhoun S, Carapetis JR, Maclennan C (2009b) Validation of an Integrated management of childhood illness algorithm for managing common skin conditions in Fiji. Bull World Health Organ 87:173–179

    Article  PubMed  PubMed Central  Google Scholar 

  • Strong M, Johnstone P (2007) Interventions for treating scabies. Cochrane Database Syst Rev July 18 Issue 3; CD000320

    Google Scholar 

  • Swe PM, Fischer K (2014) A scabies mite serpin interferes with complement-mediated neutrophil functions and promotes staphylococcal growth. PLoS Negl Trop Dis 8:e2928

    Article  PubMed  PubMed Central  Google Scholar 

  • Swe PM, Reynolds SL, Fischer K (2014) Parasitic scabies mites and associated bacteria joining forces against host complement defence. Parasite Immunol 36:585–593

    Article  CAS  PubMed  Google Scholar 

  • Taplin D, Porcelain SL, Meinking TL, Athey RL, Chen JA, Castillero PM, Sanchez R (1991) Community control of scabies: a model based on use of permethrin cream. Lancet 337:1016–1018

    Article  CAS  PubMed  Google Scholar 

  • Thomas WR (2015) Hierarchy and molecular properties of house dust mite allergens. Allergol Int 64:304–311

    Article  CAS  PubMed  Google Scholar 

  • Thomas M, Woodfield G, Moses C, Amos G (2005) Soil-transmitted helminth infection, skin infection, anaemia, and growth retardation in schoolchildren of Taveuni Island, Fiji. N Z Med J Jun 3; 118(1216):U1492

    Google Scholar 

  • Thomas J, Peterson GM, Walton SF, Carson CF, Naunton M, Baby KE (2015) Scabies: an ancient global disease with a need for new therapies. BMC Infect Dis 15:250

    Article  PubMed  PubMed Central  Google Scholar 

  • Tong SY, Bishop EJ, Lilliebridge RA, Cheng AC, Spasova-Penkova Z, Holt DC, Giffard PM, McDonald MI, Currie BJ, Boutlis CS (2009) Community-associated strains of methicillin-resistant Staphylococcus aureus and methicillin-susceptible S. aureus in indigenous Northern Australia: epidemiology and outcomes. J Infect Dis 199:1461–1470

    Article  PubMed  Google Scholar 

  • Tonkin SL, Wynne-Jones N (1979) Tokelau Islands children’s study: Scabies infestation in children. N Z Med J 90:8–11

    CAS  PubMed  Google Scholar 

  • Usha V, Gopalakrishnan Nair TV (2000) A comparative study of oral ivermectin and topical permethrin cream in the treatment of scabies. J Am Acad Dermatol 42:236–240

    Article  CAS  PubMed  Google Scholar 

  • Valery PC, Wenitong M, Clements V, Sheel M, McMillan D, Stirling J, Sriprakash KS, Batzloff M, Vohra R, McCarthy JS (2008) Skin infections among Indigenous Australians in an urban setting in Far North Queensland. Epidemiol Infect 136:1103–1108

    Article  CAS  PubMed  Google Scholar 

  • van der Aar AM, Sibiryak DS, Bakdash G, van Capel TM, van der Kleij HP, Opstelten DJ, Teunissen MB, Kapsenberg ML, de Jong EC (2011) Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory T cells. J Allergy Clin Immunol 127:1532–1540, e7

    Article  PubMed  CAS  Google Scholar 

  • Vince JD (2015) Millennium Development Goals: progress in Oceania. Arch Dis Child 100(Suppl 1):S63–S65

    Article  PubMed  Google Scholar 

  • Vogel AM, Lennon DR, Gray S, Farrell E, Anderson P (2013) Registered nurse assessment and treatment of skin sepsis in New Zealand schools: The development of protocols. N Z Med J 126:15–26

    Google Scholar 

  • Walton SF (2010) The immunology of susceptibility and resistance to scabies. Parasite Immunol 32:532–540

    CAS  PubMed  Google Scholar 

  • Walton SF, Currie BJ (2007) Problems in diagnosing scabies, a global disease in human and animal populations. Clin Microbiol Rev 20:268–279

    Article  PubMed  PubMed Central  Google Scholar 

  • Walton SF, Oprescu FI (2013) Immunology of scabies and translational outcomes: identifying the missing links. Curr Opin Infect Dis 26:116–122

    Article  CAS  PubMed  Google Scholar 

  • Walton SF, Weir C (2012) The interplay between diet and emerging allergy: what can we learn from Indigenous Australians? Int Rev Immunol 31:184–201

    Article  CAS  PubMed  Google Scholar 

  • Walton SF, McBroom J, Mathews JD, Kemp DJ, Currie BJ (1999) Crusted scabies: a molecular analysis of Sarcoptes scabiei variety hominis populations from patients with repeated infestations. Clin Infect Dis 29:1226–1230

    Article  CAS  PubMed  Google Scholar 

  • Walton SF, Myerscough MR, Currie BJ (2000) Studies in vitro on the relative efficacy of current acaricides for Sarcoptes scabiei var. hominis. Trans R Soc Trop Med Hyg 94:92–96

    Article  CAS  PubMed  Google Scholar 

  • Walton SF, Dougall A, Pizzutto S, Holt DC, Taplin D, Arlian LG, Morgan M, Currie BJ, Kemp DJ (2004) Genetic epidemiology of Sarcoptes scabiei (Acari: Sarcoptidae) in northern Australia. Int J Parasitol 34:839–849

    Article  CAS  PubMed  Google Scholar 

  • Walton SF, Beroukas D, Roberts-Thomson P, Currie BJ (2008) New insights into disease pathogenesis in crusted (Norwegian) scabies: the skin immune response in crusted scabies. Br J Dermatol 158:1247–1255

    Article  CAS  PubMed  Google Scholar 

  • Walton SF, Pizzutto S, Slender A, Viberg L, Holt D, Hales BJ, Kemp DJ, Currie BJ, Rolland JM, O’Hehir R (2010) Increased allergic immune response to Sarcoptes scabiei antigens in crusted versus ordinary scabies. Clin Vaccine Immunol 17:1428–1438

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Walton SF, Slender A, Pizutto S, Mounsey KE, Opresecu F, Thomas WR, Hales BJ, Currie BJ (2015a) Analysis of IgE binding patterns to house dust mite allergens in scabies-endemic communities: insights for both diseases. Clin Exp Allergy 45:1868–1872

    Article  CAS  PubMed  Google Scholar 

  • Walton S, Slender A, Pizutto S, Mounsey K, Opresecu F, Thomas WR, Hales BJ, Currie BJ (2015b) Analysis of IgE binding patterns to house dust mite allergens in scabies endemic communities: insights for both diseases. Clin Exp Allergy 45:1868–1872

    Article  CAS  PubMed  Google Scholar 

  • Wells B, Burgess STG, McNeilly TN, Huntley JF, Nisbet AJ (2012) Recent developments in the diagnosis of ectoparasite infections and disease through a better understanding of parasite biology and host responses. Mol Cell Probes 26:47–53

    Article  CAS  PubMed  Google Scholar 

  • Whitehall J, Kuzulugil D, Sheldrick K, Wood A (2013) Burden of paediatric pyoderma and scabies in North West Queensland. J Paediatr Child Health 49:141–143

    Article  PubMed  Google Scholar 

  • Wong LC, Amega B, Connors C, Barker R, Dulla ME, Ninnal A, Kolumboort L, Cumaiyi MM, Currie BJ (2001) Outcome of an interventional program for scabies in an Indigenous community. Med J Aust 175:367–370

    CAS  PubMed  Google Scholar 

  • Wong LC, Amega B, Barker R, Connors C, Dulla ME, Ninnal A, Cumaiyi MM, Kolumboort L, Currie BJ (2002) Factors supporting sustainability of a community-based scabies control program. Australas J Dermatol 43:274–277

    Article  PubMed  Google Scholar 

  • Wong SS, Poon RW, Chau S, Wong SC, To KK, Cheng VC, Fung KS, Yuen KY (2015) Development of conventional and real-time quantitative PCR assays for diagnosis and monitoring of scabies. J Clin Microbiol 53:2095–2102

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Worth C, Heukelbach J, Fengler G, Walter B, Liesenfeld O, Feldmeier H (2012) Impaired quality of life in adults and children with scabies from an impoverished community in Brazil. Int J Dermatol 51:275–282

    Article  PubMed  Google Scholar 

  • Zhang R, Jise Q, Zheng W, Ren Y, Nong X, Wu X, Gu X, Wang S, Peng X, Lai S, Yang G (2012) Characterization and evaluation of a Sarcoptes scabiei allergen as a candidate vaccine. Parasit Vectors 5:176

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. Inflammation and Healing Research Cluster, Faculty of Science, Health, Education and Engineering, University of Sunshine Coast, Sippy Downs, QLD, Australia

    Shelley F. Walton

  2. Menzies School of Health Research, Charles Darwin University and Royal Darwin Hospital, Darwin, NT, Australia

    Bart J. Currie

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  1. Shelley F. Walton
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Correspondence to Shelley F. Walton .

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  1. Health and Medicine, Australian Institute of Tropical Health and Medicine James Cook University, Cairns, Queensland, Australia

    Alex Loukas

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Walton, S.F., Currie, B.J. (2016). Scabies. In: Loukas, A. (eds) Neglected Tropical Diseases - Oceania. Neglected Tropical Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-43148-2_10

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