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Epidemiology of Cardio-Oncology

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Cardio-Oncology

Abstract

The main purpose of this chapter is to explore the converging epidemiology of cancer and heart disease. Multiple factors appear to be driving the convergence. On the one hand, there are modifiable risk factors, which, along with aging, influence risk of cardiovascular disease (CVD) and specific malignancies. Emerging evidence suggests that inflammation might be one of the common mechanisms linking diet, obesity, tobacco use, and time to these two seemingly disparate diseases. The second, and equally important, drive for the growing clinical interaction between cardiology and oncology is the adverse effect that cancer therapy has on the heart and vasculature. Cardiovascular toxicity is both a short- and long-term complication of chemo-, biologic, and radiation therapies. Less well understood is the potential that cancers and cardiovascular diseases share common genetic susceptibilities. An appreciation of the converging epidemiology for cancer and heart disease will lay the foundation for developing prevention and treatment strategies.

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Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, University of Louisville, Louisville, KY, USA

    Carrie Geisberg Lenneman M.D., MSCI

  2. Department of Medicine, Duke University Medical Center, Durham, NC, USA

    Gretchen G. Kimmick

  3. Maine Medical Center, Cardiovascular Institute, Portland, ME, USA

    Douglas B. Sawyer

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  1. Carrie Geisberg Lenneman M.D., MSCI
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  2. Gretchen G. Kimmick
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  3. Douglas B. Sawyer
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Correspondence to Carrie Geisberg Lenneman M.D., MSCI .

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  1. Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA

    Gretchen G. Kimmick

  2. Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA

    Daniel J. Lenihan

  3. Maine Medical Center, Cardiovascular Institute, Portland, Maine, USA

    Douglas B. Sawyer

  4. Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

    Erica L. Mayer

  5. Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, USA

    Dawn L. Hershman

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© 2017 Springer International Publishing Switzerland

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Lenneman, C.G., Kimmick, G.G., Sawyer, D.B. (2017). Epidemiology of Cardio-Oncology. In: Kimmick, G., Lenihan, D., Sawyer, D., Mayer, E., Hershman, D. (eds) Cardio-Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-43096-6_1

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  • DOI: https://doi.org/10.1007/978-3-319-43096-6_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-43094-2

  • Online ISBN: 978-3-319-43096-6

  • eBook Packages: MedicineMedicine (R0)

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