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The Circuitry Underlying the Reinstatement of Cocaine Seeking: Modulation by Deep Brain Stimulation

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The Basal Ganglia

Part of the book series: Innovations in Cognitive Neuroscience ((Innovations Cogn.Neuroscience))

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Abstract

Cocaine addiction in humans is characterized by persistent relapse vulnerability following detoxification. Relapse to drug taking can be precipitated by several factors: stress, re-exposure to drug-associated environmental cues, and re-exposure to the drug itself. Preclinical studies have focused on cocaine reinstatement, an animal model of relapse, to achieve a greater understanding of the underlying anatomical, neurobiological, and neurochemical bases of cocaine craving and relapse. Here, we review how changes in dopaminergic and glutamatergic transmission in mesocorticolimbic nuclei contribute to the reinstatement of cocaine seeking. This information can be used to elucidate which nuclei may prove effective therapeutic targets for deep brain stimulation (DBS) as a treatment for cocaine craving and relapse.

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Authors and Affiliations

  1. Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Leonardo A. Guercio

  2. Department of Psychiatry, Center for Neurobiology and Behavior, Perelman School of Medicine, University of Pennsylvania, 125 S. 31st Street, Philadelphia, PA, 19104, USA

    Leonardo A. Guercio & R. Christopher Pierce Ph.D.

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  1. Leonardo A. Guercio
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  2. R. Christopher Pierce Ph.D.
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Correspondence to R. Christopher Pierce Ph.D. .

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  1. Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, USA

    Jean-Jacques Soghomonian

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Guercio, L.A., Pierce, R.C. (2016). The Circuitry Underlying the Reinstatement of Cocaine Seeking: Modulation by Deep Brain Stimulation. In: Soghomonian, JJ. (eds) The Basal Ganglia. Innovations in Cognitive Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-42743-0_17

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