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The Intestinal Microbiome, the Immune System and Spondyloarthropathy

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Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The microbial communities that live in and on our bodies play complex roles in maintaining our health and in causing disease. The recent application of high-throughput DNA sequencing to examine these communities, both in terms of species present and in their activities, has proven to be a very powerful tool for examining the influences of microbes on human health. Whilst we are only just beginning to understand the role of our microbial ‘second’ genome, what is clear is that certain shifts and alterations in our microbiome are associated with, and may ultimately cause or cure, disease. The interaction between human host and microbes is multifaceted, however, and such interactions must therefore be examined in overall context of disease, diet, medications as well as underlying host genetics.

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  1. Institute of Health and Biomedical Innovation, Queensland University of Technology, Ipswich Road, Woolloongabba, QLD, 4102, Australia

    Mary-Ellen Costello & Matthew A. Brown

  2. Translational Research Institute, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, QLD, 4102, Australia

    Mary-Ellen Costello & Matthew A. Brown

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  1. US Medical Division, Eli Lilly & Company, New York, New York, USA

    Paola Mina-Osorio

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Costello, ME., Brown, M.A. (2017). The Intestinal Microbiome, the Immune System and Spondyloarthropathy. In: Mina-Osorio, P. (eds) Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases. Progress in Inflammation Research. Springer, Cham. https://doi.org/10.1007/978-3-319-42252-7_8

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