Abstract
Several environmental and endogenous factors create a variety of lesions in the genome of an organism. These lesions could potentially be genotoxic and might lead to mutations, which could be lethal. All organisms exhibit a prompt response against DNA damage, which is referred to as the DNA damage response. The existence of elaborate, evolutionarily conserved systems to repair the damage, mostly at the expense of huge amount of energy, points to the importance of safeguarding the integrity of DNA. Most of the current understanding about DNA damage response and repair pathways has been distilled through decades of research on prokaryotes, yeast, and mammalian systems. The response to genotoxic stresses and the repair mechanisms involved in plants has only recently begun to be investigated. Herein, we present a comprehensive account of the types of DNA damage, the DNA damage response, and the repair pathways with reference to the recent insights gained from the plants. Although, the underlying common theme runs through to the plants, the mechanisms in plants demonstrate some unique features. Also, there are several missing links that need to be unravelled for inferring a complete picture. A thorough understanding of the mechanisms involved would aid in devising strategies to help plants avoid irreparable damages to their genome upon exposure to genotoxic agents.
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Fatima, U., Khan, M.F., e Fatima, J., Shahab, U., Ahmad, S., Yusuf, M.A. (2017). DNA Damage, Response, and Repair in Plants Under Genotoxic Stress. In: Sarwat, M., Ahmad, A., Abdin, M., Ibrahim, M. (eds) Stress Signaling in Plants: Genomics and Proteomics Perspective, Volume 2. Springer, Cham. https://doi.org/10.1007/978-3-319-42183-4_7
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