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Sirtuins as Regulators of Cardiac Hypertrophy and Heart Failure

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Epigenetics in Cardiac Disease

Part of the book series: Cardiac and Vascular Biology ((Abbreviated title: Card. vasc. biol.,volume 1))

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Abstract

Sirtuins are emerging as key regulators of a number of biological functions ranging from cell growth, differentiation to longevity. Mammalian genome encodes seven sirtuins isoform (SIRT1–SIRT7), which are distributed in different compartment of the cells. Sirtuins need NAD+ for their enzymatic reaction. Because of their dependency on NAD, they can respond to energy need of the cells and modulate key enzymatic pathways relevant to the maintenance of cellular health. Throughout the evolution, from prokaryotes to mammals, sirtuins are mainly valued for their ability to bestow cells with efficient adaptation to stress conditions. Sirtuins target histone and nonhistone proteins to ameliorate varied pathophysiologic conditions by controlling gene transcription and fitness of mitochondria. Many sirtuin isoforms have been also studied for their roles in regulating cardiac development and protecting the heart from pathological stress. In this review, we will discuss impact of sirtuins in overall health of the cardiovascular system.

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Acknowledgment

These studies were supported from NIH RO1 grants HL117041 and HL111455 to MPG.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Biological Science Division, University of Chicago Medicine, 5841. South Maryland Avenue, Chicago, IL, 60637, USA

    Sadhana Samant

  2. Department of Surgery, University of Chicago, 5841 South Maryland Avenue, Chicago, IL, 60637, USA

    Mahesh P. Gupta

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  1. Sadhana Samant
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  2. Mahesh P. Gupta
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Correspondence to Mahesh P. Gupta .

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Editors and Affiliations

  1. Department of Molecular, Cardiology and Epigenetics, University of Heidelberg, Heidelberg, Germany

    Johannes Backs

  2. Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, CO, USA

    Timothy A. McKinsey

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Samant, S., Gupta, M.P. (2016). Sirtuins as Regulators of Cardiac Hypertrophy and Heart Failure. In: Backs, J., McKinsey, T.A. (eds) Epigenetics in Cardiac Disease. Cardiac and Vascular Biology, vol 1. Springer, Cham. https://doi.org/10.1007/978-3-319-41457-7_11

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