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Abstract

Spinal cord injury (SCI) is a global health problem that afflicts young adults and the elderly. Motor vehicle accidents and falls remain the leading cause of SCI. It is becoming a significant social burden due to improved survival rate and access to care. In order to understand the effect of SCI, a good understanding of the functional and topographic anatomy of the spinal cord is important. The primary insult of SCI is a direct consequence of the trauma resulting in mechanical damage to the cord. Secondary injury occurs as a result of cord edema and hypoperfusion. The severity of SCI is classified by using the American Spinal Injury Association Impairment Scale. The initial phase of SCI management involves the basic ABCDE, and management of other life-threatening injuries. Once stabilized, expeditious, focused radiographic imaging is important for diagnosis of SCI. Early surgical intervention has been shown to improve clinical outcomes. Patients with high thoracic or cervical SCI may demonstrate hemodynamic instability due to sympathectomy, which requires invasive monitoring in the operating room and intensive care unit. There are significant changes to the cardiovascular, pulmonary, gastrointestinal, and urinary physiology of SCI patients, which require specialized care in a neurocritical care unit followed by intense rehabilitation therapies.

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References

  1. Rubiano AM, Carney N, Chesnut R, Puyana JC. Global neurotrauma research challenges and opportunities. Nature. 2015;527:S193–7.

    Article  CAS  PubMed  Google Scholar 

  2. National Spinal Cord Injury Statistical Center. Spinal cord injury facts and figures at a glance. Birmingham: University of Alabama at Birmingham; 2013. https://www.nscisc.uab.edu/PublicDocuments/fact_figures_docs/Facts%202013.pdf. Accessed 18 Oct 2015.

  3. Lee BB, Cripps RA, Fitzharris M, Wing PC. The global map for traumatic spinal cord injury epidemiology: update 2011, global incidence rate. Spinal Cord. 2014;52:110–6.

    Article  CAS  PubMed  Google Scholar 

  4. Devivo MJ. Epidemiology of traumatic spinal cord injury: trends and future implications. Spinal Cord. 2012;50(5):365–72.

    Article  CAS  PubMed  Google Scholar 

  5. Singh A, Tetreault L, Kalsi-Ryan S, Nouri A, Fehlings MG. Global prevalence and incidence of traumatic spinal cord injury. Clin Epidemiol. 2014;6:309–31.

    PubMed  PubMed Central  Google Scholar 

  6. Rahimi-Movaghar V, Saadat S, Rasouli MR, Ganji S, Ghahramani M, Zarei MR, Vaccaro AR. Prevalence of Spinal Cord Injury in Tehran Iran. J Spinal Cord Med. 2009;32(4):428–31.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Krueger H, Noonan VK, Trenaman LM, Joshi P, Rivers CS. The economic burden of traumatic spinal cord injury in Canada. Chronic Dis Inj Can. 2013;33(3):113–22.

    CAS  PubMed  Google Scholar 

  8. Waxman SG. Chapter 5: The spinal cord. In: Waxman SG, editor. Clinical neuroanatomy. 27th ed. New York: McGraw-Hill; 2013. http://accessmedicine.mhmedical.com/content.aspx?bookid=673&Sectionid=45395963. Accessed 24 Oct 2015.

  9. McCormick PC, Stein BM. Functional anatomy of the spinal cord and related structures. Neurosurg Clin N Am. 1990;1:469–89.

    CAS  PubMed  Google Scholar 

  10. Goulding M, Bourane S, Garcia-Campmany L, Dalet A, Koch S. Inhibition downunder: an update from the spinal cord. Curr Opin Neurobiol. 2014;26:161–6.

    Article  CAS  PubMed  Google Scholar 

  11. Jessell TM, Surmeli G, Kelly JS. Motor neurons and the sense of place. Neuron. 2011;72(3):419–24.

    Article  CAS  PubMed  Google Scholar 

  12. Melissan G, Bertoglio L, Rinaldi E, Leopardi M, Chiesa R. An anatomical review of spinal cord blood supply. J Cardiovasc Surg (Torino). 2015;56(5):699–706.

    Google Scholar 

  13. Norenberg MD, Smith J, Marcillo A. The pathology of human spinal cord injury: defining the problems. J Neurotrauma. 2004;21(4):429–40.

    Article  PubMed  Google Scholar 

  14. Sharma HS. Pathophysiology of blood-spinal cord barrier in traumatic injury and repair. Curr Pharm Des. 2005;11(11):1353–89.

    Article  CAS  PubMed  Google Scholar 

  15. Tator CH, Fehlings MG. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg. 1991;75(1):15–26.

    Article  CAS  PubMed  Google Scholar 

  16. Schwartz G, Fehlings MG. Secondary injury mechanisms of spinal cord trauma: a novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole. Prog Brain Res. 2002;137:177–90.

    Article  CAS  PubMed  Google Scholar 

  17. Allan SM, Rothwell NJ. Cytokines and acute neurodegeneration. Nat Rev Neurosci. 2001;2(10):734–44.

    Article  CAS  PubMed  Google Scholar 

  18. Carlson SL, Parrish ME, Springer JE, Doty K, Dossett L. Acute inflammatory response in spinal cord following impact injury. Exp Neurol. 1998;151(1):77–88.

    Article  CAS  PubMed  Google Scholar 

  19. Park E, Velumian AA, Fehlings MG. The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration. J Neurotrauma. 2004;21(6):754–74.

    Article  PubMed  Google Scholar 

  20. Tzekou A, Fehlings MG. Treatment of spinal cord injury with intravenous immunoglobulin G: preliminary evidence and future perspectives. J Clin Immunol. 2014;34(S1):S132–8.

    Article  PubMed  Google Scholar 

  21. American Spinal Injury Association. International standards for neurological classification of spinal cord injury. American Spinal Injury Association, Chicago; 2002. http://www.asia-spinalinjury.org/elearning/ASIA_ISCOS_high.pdf. Accessed 20 Oct 2015.

  22. Molliqaj G, Payer M, Schaller K, Tessitore E. Acute traumatic central cord syndrome: a comprehensive review. Neurochirurgie. 2014;60(1-2):5–11.

    Article  CAS  PubMed  Google Scholar 

  23. Brown-Séquard C-É. De la transmission croisée des impressions sensitives par la moelle épinière. C R Soc Biol. 1851;2:33–44.

    Google Scholar 

  24. Leven D, Sadr A, Aibinder WR. Brown-Séquard syndrome after a gun shot wound to the cervical spine: a case report. Spine J. 2013;13(12):e1–5.

    Article  PubMed  Google Scholar 

  25. Nacimiento W, Noth J. What, if anything, is spinal shock? Arch Neurol. 1999;56:1033–5.

    Article  CAS  PubMed  Google Scholar 

  26. Atkinson PP, Atkinson JL. Spinal shock. Mayo Clin Proc. 1996;71:384–9.

    Article  CAS  PubMed  Google Scholar 

  27. Ditunno JF, Little JW, Tessler A, Burns AS. Spinal shock revisited: a four-phase model. Spinal Cord. 2004;42(7):383–95.

    Article  CAS  PubMed  Google Scholar 

  28. Sundstrøm T, Asbjørnsen H, Habiba S, Sunde GA, Wester K. Prehospital use of cervical collars in trauma patients: a critical review. J Neurotrauma. 2014;31(6):531–40.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Austin N, Krishnamoorthy V, Dagal A. Airway management in cervical spine injury. Int J Crit Illn Inj Sci. 2014;4(1):50–6.

    Article  PubMed  PubMed Central  Google Scholar 

  30. American College of Surgeons. Advanced trauma life support. https://www.facs.org/quality-programs/trauma/atls. Accessed 1 Nov 2015.

  31. Standard and Practice Parameters Committee. Standard for basic anesthetic monitoring. http://www.asahq.org/~/media/Sites/ASAHQ/Files/Public/Resources/standards-guidelines/standards-for-basic-anesthetic-monitoring.pdf. American Society of Anesthesiologists. Last amended 2010, reaffirmed 2015. Accessed 20 Dec 2015.

  32. El-Orbany M, Connolly LA. Rapid sequence induction and intubation: current controversy. Anesth Analg. 2010;110(5):1318–25.

    Article  PubMed  Google Scholar 

  33. Doyle DJ. 2004 GlideScope-assisted fiberoptic intubation: a new airway teaching method. Anesthesiology. 2004;101(11):1252.

    Article  PubMed  Google Scholar 

  34. Heath KJ. The effect of laryngoscopy of different cervical spine immobilisation techniques. Anaesthesia. 1994;49(10):843–5.

    Article  CAS  PubMed  Google Scholar 

  35. Hoffman JR, Wolfson AB, Todd K, Mower WR. Selective cervical spine radiography in blunt trauma: methodology of the National Emergency X-Radiography Utilization Study (NEXUS). Ann Emerg Med. 1998;32(4):461.

    Article  CAS  PubMed  Google Scholar 

  36. Halpern CH, Milby AH, Guo W, Schuster JM, Gracias VH, Stein SC. Clearance of the cervical spine in clinically unevaluable trauma patients. Spine. 2010;35(18):1721.

    Article  PubMed  Google Scholar 

  37. Schuster R, Waxman K, Sanchez B, Becerra S, Chung R, Conner S, Jones T. Magnetic resonance imaging is not needed to clear cervical spines in blunt trauma patients with normal computed tomographic results and no motor deficits. Arch Surg. 2005;140(8):762.

    Article  PubMed  Google Scholar 

  38. Bracken MB, Shepard MJ, Holford TR, Leo-Summers L, Aldrich EF, Fazl M, et al. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the third national acute spinal cord injury randomized controlled trial. National acute spinal cord injury study. JAMA. 1997;277:1597–604.

    Article  CAS  PubMed  Google Scholar 

  39. Otani K, Abe H, Kadoya S, Nakagawa H, Ikata T, Tominaga S. Beneficial effect of methylprednisolone sodium succinate in the treatment of acute spinal cord injury. Sekitsui Sekizui. 1994;7:633–47.

    Google Scholar 

  40. Bracken MB. Steroids for acute spinal cord injury. Cochrane Database Syst Rev. 2012;(1):CD001046.

    Google Scholar 

  41. Pointillart V, Petitjean ME, Wiart L, Vital JM, Lassié P, Thicoipé M, et al. Pharmacological therapy of spinal cord injury during the acute phase. Spinal Cord. 2000;38:71–6.

    Article  CAS  PubMed  Google Scholar 

  42. Cheung V, Hoshide R, Bansal V, Kasper E, Chen CC. Methylprednisolone in the management of spinal cord injuries: lessons from randomized, controlled trials. Surg Neurol Int. 2015;6:142.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Fehlings MG, Vaccaro A, Wilson JR, Singh AW, Cadotte D, Harrop JS, Aarabi B, Shaffrey C, Dvorak M, Fisher C, Arnold P, Massicotte EM, Lewis S, Rampersaud R. Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS). PLoS One. 2012;7(2):e32037.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Spencer KT, Kimura BJ, Korcarz CE, Pellikka PA, Rahko PS, Siegel RJ. Focused cardiac ultrasound: recommendations from the American Society of Echocardiography. J Am Soc Echocardiogr. 2013;26(6):567–81.

    Article  PubMed  Google Scholar 

  45. Lichtenstein DA, Mezière GA. Relevance of lung ultrasound in the diagnosis of acute respiratory failure: the BLUE protocol. Chest. 2008;134(1):117–25.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Marik PE, Cavallazzi R, Vasu T, Hirani A. Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: a systematic review of the literature. Crit Care Med. 2009;37(9):2642–7.

    Article  PubMed  Google Scholar 

  47. Biais M, Bernard O, Ha JC, Degryse C, Sztark F. Abilities of pulse pressure variations and stroke volume variations to predict fluid responsiveness in prone position during scoliosis surgery. Br J Anaesth. 2010;104(4):407–13.

    Article  CAS  PubMed  Google Scholar 

  48. Michalilidou C, Martson L, Sutherland I. A systematic review of the prevalence of musculoskeletal pain, back and low back pain in people with spinal cord injury. Disabil Rehabil. 2014;36(9):705–15.

    Article  Google Scholar 

  49. Grigorean VT, Sandu AM, Popescu M, Iacobini MA, Stoian R, Neascu C, Strambu V, Popa F. Cardiac dysfunctions following spinal cord injury. J Med Life. 2009;2(2):133–45.

    PubMed  PubMed Central  Google Scholar 

  50. Furlan JC, Verocai F, Palmares X, Fehlings MG. Electrocardiographic abnormalities in the early stage following traumatic spinal cord injury. Spinal Cord. 2016;54(10):852–77. doi:10.1038/sc.2016.11.

    Article  Google Scholar 

  51. Teasell RW, Arnold JM, Krassioukov A, Delaney GA. Cardiovascular consequences of loss of supraspinal control of the sympathetic nervous system after spinal cord injury. Arch Phys Med Rehabil. 2000;81(4):506–16.

    Article  CAS  PubMed  Google Scholar 

  52. Hagen EM, Faerestrand S, Hoff JM, Rekand T, Gronning M. Cardiovascular and urological dysfunction in spinal cord injury. Acta Neurol Scand Suppl. 2011;191:71–8.

    Article  Google Scholar 

  53. Rodrigues D, Tran Y, Guest R, Middleton J, Craig A. Influence of neurological lesion level on heart rate variability and fatigue in adults with spinal cord injury. Spinal Cord. 2016;54(4):292–7.

    Article  CAS  PubMed  Google Scholar 

  54. Ryken TC, Hurlbert RJ, Hadley MN, Aarabi B, Dhall SS, Gelb DE, Rozzelle CJ, Theodore N, Walters BC. The acute cardiopulmonary management of patients with cervical spinal cord injuries. Neurosurgery. 2013;72:84–92.

    Article  PubMed  Google Scholar 

  55. Jackson AB, Groomes TE. Incidence of respiratory complications following spinal cord injury. Arch Phys Med Rehabil. 1994;75(3):270–5.

    Article  CAS  PubMed  Google Scholar 

  56. Lidal IB, Snekkevik H, Aamodt G, Hjeltnes N, Biering-Sørensen F, Stanghelle JK. Mortality after spinal cord injury in Norway. J Rehabil Med. 2007;39(2):145–51.

    Article  PubMed  Google Scholar 

  57. Brown R, DiMarco AF, Hoit JD, Garshick E. Respiratory dysfunction and management in spinal cord injury. Respir Care. 2006;51(8):853–68.

    PubMed  PubMed Central  Google Scholar 

  58. Stepp EL, Brown R, Tun CG, Gagnon DR, Jain NB, Garshick E. Determinants of lung volumes in chronic spinal cord injury. Arch Phys Med Rehabil. 2008;89(8):1499–506.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Fishburn MJ, Marino RJ, Ditunno Jr JF. Atelectasis and pneumonia in acute spinal cord injury. Arch Phys Med Rehabil. 1990;71(3):197–200.

    CAS  PubMed  Google Scholar 

  60. Schileroa GJ, Spungena AM, Baumana WA, Radulovica M, Lessera M. Pulmonary function and spinal cord injury. Respir Physiol Neurobiol. 2009;166(3):129–41.

    Article  Google Scholar 

  61. Claxton AR, Wong DT, Chung F, Fehlings MG. Predictors of hospital mortality and mechanical ventilation in patients with cervical spinal cord injury. Can J Anaesth. 1998;45(2):144–9.

    Article  CAS  PubMed  Google Scholar 

  62. Mueller G, de Groot S, van der Woude L, Hopman MT. Time-courses of lung function and respiratory muscle pressure generating capacity after spinal cord injury: a prospective cohort study. J Rehabil Med. 2008;40(4):269–76.

    Article  PubMed  Google Scholar 

  63. Call MS, Kutcher ME, Izenberg RA, Singh T, Cohen MJ. Spinal Cord Injury: Outcomes of ventilatory weaning and extubation. J Trauma. 2011;71(6):1673–9.

    PubMed  Google Scholar 

  64. Wong SL, Shem K, Crew J. Specialized respiratory management for acute cervical spinal cord injury: a retrospective analysis. Top Spinal Cord Inj Rehabil. 2012;18(4):283–90.

    Article  PubMed  Google Scholar 

  65. Romero J, Vari A, Gambarrutta C, Oliviero A. Tracheostomy timing in traumatic spinal cord injury. Eur Spine J. 2009;18(10):1452–7.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Choi HJ, Paeng SH, Kim ST, Lee KS, Kim MS, Jung YT. The effectiveness of early tracheostomy (within at least 10 Days) in cervical spinal cord injury patients. J Korean Neurosurg Soc. 2013;54(3):220–4.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Gomes Silva BN, Andriolo RB, Saconato H, Atallah AN, Valente O. Early versus late tracheostomy for critically ill patients. Cochrane Database Syst Rev. 2012;(3):CD007271.

    Google Scholar 

  68. Liu CC, Livingstone D, Dixon E, Dort JC. Early versus late tracheostomy: a systematic review and meta-analysis. Otolaryngol Head Neck Surg. 2015;152(2):219–27.

    Article  PubMed  Google Scholar 

  69. Almenoff PL, Alexander LR, Spungen AM, Lesser MD, Bauman WA. Bronchodilatory effects of ipratropium bromide in patients with tetraplegia. Paraplegia. 1995;33(5):274–7.

    Article  CAS  PubMed  Google Scholar 

  70. Wadsworth BM, Haines TP, Cornwell PL, Rodwell LT, Paratz JD. Abdominal binder improves lung volumes and voice in people with tetraplegic spinal cord injury. Arch Phys Med Rehabil. 2012;93(12):2189–97.

    Article  PubMed  Google Scholar 

  71. Roussi J, Bentolila S, Boudaoud L, Casadevall N, Vallée C, Carlier R, Lortat-Jacob S, Dizien O, Bussel B. Contribution of D-Dimer determination in the exclusion of deep venous thrombosis in spinal cord injury patients. Spinal Cord. 1999;37(8):548–52.

    Article  CAS  PubMed  Google Scholar 

  72. Ploumis A, Ponnappan RK, Maltenfort MG, Patel RX, Bessey JT, Albert TJ, Harrop JS, Fisher CG, Bono CM, Vaccaro AR. Thromboprophylaxis in patients with acute spinal injuries: an evidence-based analysis. J Bone Joint Surg Am. 2009;91(11):2568–76.

    Article  CAS  PubMed  Google Scholar 

  73. Gould MK, Garcia DA, Wren SM, Karanicolas PJ, Arcelus JI, Heit JA, Samama CM, American College of Chest Physicians. Prevention of VTE in nonorthopedic surgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e227S–77S.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Spinal Cord Injury Thromboprophylaxis Investigators. Prevention of venous thromboembolism in the acute treatment phase after spinal cord injury: a randomized, multicenter trial comparing low-dose heparin plus intermittent pneumatic compression with enoxaparin. J Trauma. 2003;54(6):1116–24.

    Article  Google Scholar 

  75. Johns JS, Nguyen C, Sing RF. Vena cava filters in spinal cord injuries: evolving technology. J Spinal Cord Med. 2006;29(3):183–90.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Giannoudis PV, Pountos I, Pape HC, Patel JV. Safety and efficacy of vena cava filters in trauma patients. Injury. 2007;38(1):7–18.

    Article  PubMed  Google Scholar 

  77. Patel SH, Patel R. Inferior vena cava filters for recurrent thrombosis: current evidence. Tex Heart Inst J. 2007;34(2):187–94.

    PubMed  PubMed Central  Google Scholar 

  78. Blebea J, Wilson R, Waybill P, Neumyer MM, Blebea JS, Anderson KM, Atnip RG. Deep venous thrombosis after percutaneous insertion of vena caval filters. J Vasc Surg. 1999;30(5):821–8.

    Article  CAS  PubMed  Google Scholar 

  79. van der Wielen H, Post MW, Lay V, Gläsche K, Scheel-Sailer A. Hospital-acquired pressure ulcers in spinal cord injured patients: time to occur, time until closure and risk factors. Spinal Cord. doi:10.1038/sc.2015.239.

  80. Groah SL, Schladen M, Pineda CG, Hsieh CH. Prevention of pressure ulcers among people with spinal cord injury: a systematic review. PM R. 2015;7(6):613–36.

    Article  PubMed  Google Scholar 

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Correspondence to Michael J. Souter MB ChB, FRCA, FNCS .

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Luk, K.H.K., Souter, M.J. (2017). Spinal Cord Injury. In: Khan, Z. (eds) Challenging Topics in Neuroanesthesia and Neurocritical Care. Springer, Cham. https://doi.org/10.1007/978-3-319-41445-4_6

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