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Acute Appendicitis

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Pediatric Digestive Surgery
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Abstract

Acute appendicitis is the most common cause for emergency abdominal surgery in children.

The estimated incidence ranges from 1 to 6/10,000 between birth and 4 years of age and from 19 to 28/10,000 between 5 and 14 years of age. Boys are more frequently affected than girls.

Obstruction of the appendiceal lumen is the first pathogenetic moment. The lack of physiologic washout of the lumen causes distension of the lumen, wall thickness, and bacterial overgrowth. Mucosal barrier is overwhelmed, leading to bacterial invasion of the wall, inflammation, ischemia, gangrene, and eventually perforation. The clinical presentation of acute appendicitis classically includes anorexia, periumbilical pain at the onset, migration of pain in the lower right quadrant, vomiting (after the pain onset), fever, right lower tenderness, and signs of peritoneal irritation. This classical pattern is less common in pediatric age. The risk of acute appendicitis can be estimated using the pediatric appendicitis score (PAS), and in doubtful cases, imaging can help the diagnosis. The treatment consists of appendectomy which should be performed laparoscopically (if available). Prognosis is excellent in most of the cases. Complications include wound infections, intra-abdominal abscesses, peritoneal adhesions, and stump appendicitis.

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References

  1. Scholer SJ, Pituch K, Orr DP, Dittus RS (1996) Clinical outcomes of children with acute abdominal pain. Pediatrics 98:680

    CAS  PubMed  Google Scholar 

  2. Reynolds SL, Jaffe DM (1992) Diagnosing abdominal pain in a pediatric emergency department. Pediatr Emerg Care 8:126

    Article  CAS  PubMed  Google Scholar 

  3. Addiss DG, Shaffer N, Fowler BS, Tauxe RV (1990) The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 132:910

    CAS  PubMed  Google Scholar 

  4. Ohmann C, Franke C, Kraemer M, Yang Q (2002) Status report on epidemiology of acute appendicitis. Chirurg 73:769

    Article  CAS  PubMed  Google Scholar 

  5. Anderson JE, Bickler SW, Chang DC, Talamini MA (2012) Examining a common disease with unknown etiology: trends in epidemiology and surgical management of appendicitis in California, 1995–2009. World J Surg 36:2787

    Article  PubMed  Google Scholar 

  6. Rothrock SG, Pagane J (2000) Acute appendicitis in children: emergency department diagnosis and management. Ann Emerg Med 36:39

    Article  CAS  PubMed  Google Scholar 

  7. Rothrock SG, Skeoch G, Rush JJ, Johnson NE (1991) Clinical features of misdiagnosed appendicitis in children. Ann Emerg Med 20:45

    Article  CAS  PubMed  Google Scholar 

  8. Akbulut S, Ulku A, Senol A et al (2010) Left-sided appendicitis: review of 95 published cases and a case report. World J Gastroenterol 16:5598

    Article  PubMed  PubMed Central  Google Scholar 

  9. Bundy DG, Byerley JS, Liles EA et al (2007) Does this child have appendicitis? JAMA 298:438

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Rabah R (2007) Pathology of the appendix in children: an institutional experience and review of the literature. Pediatr Radiol 37:15

    Article  PubMed  Google Scholar 

  11. Bennion RS, Baron EJ, Thompson JE Jr et al (1990) The bacteriology of gangrenous and perforated appendicitis – revisited. Ann Surg 211:165

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Schwartz KL, Gilad E, Sigalet D et al (2011) Neonatal acute appendicitis: a proposed algorithm for timely diagnosis. J Pediatr Surg 46:2060

    Article  PubMed  Google Scholar 

  13. Karaman A, CavuÅŸoÄŸlu YH, Karaman I, Cakmak O (2003) Seven cases of neonatal appendicitis with a review of the English language literature of the last century. Pediatr Surg Int 19:707

    Article  PubMed  Google Scholar 

  14. Sakellaris G, Tilemis S, Charissis G (2005) Acute appendicitis in preschool-age children. Eur J Pediatr 164:80

    Article  PubMed  Google Scholar 

  15. Colvin JM, Bachur R, Kharbanda A (2007) The presentation of appendicitis in preadolescent children. Pediatr Emerg Care 23:849

    Article  PubMed  Google Scholar 

  16. Bates MF, Khander A, Steigman SA et al (2014) Use of white blood cell count and negative appendectomy rate. Pediatrics 133:e39

    Article  PubMed  Google Scholar 

  17. Kharbanda AB, Cosme Y, Liu K et al (2011) Discriminative accuracy of novel and traditional biomarkers in children with suspected appendicitis adjusted for duration of abdominal pain. Acad Emerg Med 18:567

    Article  PubMed  PubMed Central  Google Scholar 

  18. Gavela T, Cabeza B, Serrano A, Casado-Flores J (2012) C-reactive protein and procalcitonin are predictors of the severity of acute appendicitis in children. Pediatr Emerg Care 28:416

    Article  PubMed  Google Scholar 

  19. Samuel M (2002) Pediatric appendicitis score. J Pediatr Surg 37:877

    Article  PubMed  Google Scholar 

  20. Goldman RD, Carter S, Stephens D et al (2008) Prospective validation of the pediatric appendicitis score. J Pediatr 153:278

    Article  PubMed  Google Scholar 

  21. Hatcher-Ross K (2009) Sensitivity and specificity of the Pediatric Appendicitis Score. J Pediatr 154:308

    Article  PubMed  Google Scholar 

  22. Bhatt M, Joseph L, Ducharme FM et al (2009) Prospective validation of the pediatric appendicitis score in a Canadian pediatric emergency department. Acad Emerg Med 16:591

    Article  PubMed  Google Scholar 

  23. Ebell MH, Shinholser J (2014) What are the most clinically useful cutoffs for the Alvarado and Pediatric Appendicitis Scores? A systematic review. Ann Emerg Med 64:365

    Article  PubMed  Google Scholar 

  24. Zúñiga RV, Arribas JL, Montes SP et al (2012) Application of Pediatric Appendicitis Score on the emergency department of a secondary level hospital. Pediatr Emerg Care 28:489

    Article  PubMed  Google Scholar 

  25. Mittal MK, Dayan PS, Macias CG et al (2013) Performance of ultrasound in the diagnosis of appendicitis in children in a multicenter cohort. Acad Emerg Med 20:697

    Article  PubMed  Google Scholar 

  26. Doria AS, Moineddin R, Kellenberger CJ et al (2006) US or CT for diagnosis of appendicitis in children and adults? A meta-analysis. Radiology 241:83

    Article  PubMed  Google Scholar 

  27. Lowe LH, Penney MW, Stein SM et al (2001) Unenhanced limited CT of the abdomen in the diagnosis of appendicitis in children: comparison with sonography. AJR Am J Roentgenol 176:31

    Article  CAS  PubMed  Google Scholar 

  28. Bachur RG, Hennelly K, Callahan MJ et al (2012) Diagnostic imaging and negative appendectomy rates in children: effects of age and gender. Pediatrics 129:877

    Article  PubMed  Google Scholar 

  29. Aziz O, Athanasiou T, Tekkis PP et al (2006) Laparoscopic versus open appendectomy in children: a meta-analysis. Ann Surg 243:17

    Article  PubMed  PubMed Central  Google Scholar 

  30. Sauerland S, Jaschinski T, Neugebauer EA (2010) Laparoscopic versus open surgery for suspected appendicitis. Cochrane Database Syst Rev. (1):CD001546.

    Google Scholar 

  31. St Peter SD, Adibe OO, Juang D et al (2011) Single incision versus standard 3-port laparoscopic appendectomy: a prospective randomized trial. Ann Surg 254:586

    Article  PubMed  Google Scholar 

  32. Bhangu A, United Kingdom National Surgical Research Collaborative (2014) Safety of short, in-hospital delays before surgery for acute appendicitis: multicentre cohort study, systematic review, and meta-analysis. Ann Surg 259:894

    Article  PubMed  Google Scholar 

  33. St Peter SD, Aguayo P, Fraser JD et al (2010) Initial laparoscopic appendectomy versus initial nonoperative management and interval appendectomy for perforated appendicitis with abscess: a prospective, randomized trial. J Pediatr Surg 45:236

    Article  PubMed  Google Scholar 

  34. Allemann P, Probst H, Demartines N et al (2011) Prevention of infectious complications after laparoscopic appendectomy for complicated acute appendicitis – the role of routine abdominal drainage. Langenbecks Arch Surg 396(1):63–68. doi:10.1007/s00423-010-0709-z. Epub 2010 Sep 10

    Article  PubMed  Google Scholar 

  35. Lee SL, Islam S, Cassidy LD, et al (2010) Antibiotics and appendicitis in the pediatric population: an American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review. J Pediatr Surg 45:2181

    Google Scholar 

  36. Hamill JK, Liley A, Hill AG (2015) Rectus sheath block for laparoscopic appendicectomy: a randomized clinical trial. ANZ J Surg 85(12):951–956. doi:10.1111/ans.12950

    Article  PubMed  Google Scholar 

  37. Lee SL, Yaghoubian A, Kaji A (2011) Laparoscopic vs open appendectomy in children: outcomes comparison based on age, sex, and perforation status. Arch Surg 146:1118

    Article  PubMed  Google Scholar 

  38. Lee SL, Yaghoubian A, de Virgilio C (2011) A multi-institutional comparison of pediatric appendicitis outcomes between teaching and nonteaching hospitals. J Surg Educ 68:6

    Article  PubMed  Google Scholar 

  39. Tsao KJ, St Peter SD, Valusek PA et al (2007) Adhesive small bowel obstruction after appendectomy in children: comparison between the laparoscopic and open approach. J Pediatr Surg 42:939

    Article  PubMed  Google Scholar 

  40. Liang MK, Lo HG, Marks JL (2006) Stump appendicitis: a comprehensive review of literature. Am Surg 72:162

    PubMed  Google Scholar 

  41. Mangi AA, Berger DL (2000) Stump appendicitis. Am Surg 66:739

    CAS  PubMed  Google Scholar 

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Correspondence to Michela Maffi .

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Maffi, M., Lima, M. (2017). Acute Appendicitis. In: Lima, M. (eds) Pediatric Digestive Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-40525-4_20

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  • DOI: https://doi.org/10.1007/978-3-319-40525-4_20

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-319-40525-4

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