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Modulation of Memory Consolidation, Retrieval and Extinction by Brain Histamine

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Histamine Receptors

Part of the book series: The Receptors ((REC,volume 28))

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Abstract

The brain histaminergic system, whose cell bodies are in the tuberomammilary nucleus, regulates various memory types. The best studied is inhibitory avoidance, which depends on histamine H2 receptors in hippocampus and basolateral amygdala, contextual fear conditioning, which depends on histamine H3 receptors in hippocampus, and the extinction of these two tasks which relies on histamine H2 receptors in ventromedial prefrontal cortex, hippocampus and the basolateral amygdala. In addition, histamine can promote fear extinction through H1 receptors and inhibit it through H2 receptors, both in hippocampus.

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Acknowledgments

Work supported by the National Research council of Brazil (CNPq) and the Rio Grande do Sul State Agency for the Support of Research (FAPERGS).

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Authors and Affiliations

  1. Memory Center, Brain Institute of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul, Av. Ipiranga 6690, 90610-000, Porto Alegre, RS, Brazil

    Jociane de Carvalho Myskiw Ph.D., Cristiane R. G. Furini Ph.D. & Ivan Izquierdo M.D., Ph.D.

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  1. Jociane de Carvalho Myskiw Ph.D.
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  2. Cristiane R. G. Furini Ph.D.
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  3. Ivan Izquierdo M.D., Ph.D.
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Correspondence to Ivan Izquierdo M.D., Ph.D. .

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Editors and Affiliations

  1. Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA) – Sezione di Farmacologia e Tossicologia, Università degli Studi di Firenze, Florence, Italy

    Patrizio Blandina

  2. Dipartimento di Scienze della Salute – Sezione di Farmacologia Clinica e Oncologia, Università degli Studi di Firenze, Florence, Italy

    Maria Beatrice Passani

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de Carvalho Myskiw, J., Furini, C.R.G., Izquierdo, I. (2016). Modulation of Memory Consolidation, Retrieval and Extinction by Brain Histamine. In: Blandina, P., Passani, M. (eds) Histamine Receptors. The Receptors, vol 28. Humana, Cham. https://doi.org/10.1007/978-3-319-40308-3_14

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