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Megakaryocytic Transcription Factors in Disease and Leukemia

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Molecular and Cellular Biology of Platelet Formation

Abstract

An understanding of the transcriptional regulation of megakaryopoiesis has lagged behind that of other hematopoietic lineages due to the rarity of these cells and the relatively recent development of systems to culture large numbers of megakaryocytes. However, significant progress has been made over the past few decades resulting in the identification of many key transcription factors involved in megakaryocyte specification and maturation. A number of important principles have emerged including physical and functional interactions among a core set of transcription factors including GATA, ETS, and RUNX family members, cross antagonistic network interactions with key erythroid-specific factors in cell fate determination of bipotential erythroid-megakaryocytic progenitor cells, and a surprising overlap with hematopoietic stem cell transcriptional regulators. A high proportion of genes encoding megakaryocytic transcription factors are mutated in human thrombopoiesis disorders, and a number of these are associated with leukemia predisposition. This chapter reviews the current knowledge about transcription factors involved in megakaryopoiesis, how they interact, and how their activities are influenced by cell signaling events. It also highlights the important role that dysregulation of these factors play in certain human platelet biogenesis disorders and leukemogenesis.

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Acknowledgments

The author would like to thank the many colleagues in the field and members of the laboratory who have contributed ideas and insights to the material discussed in this chapter. I apologize for any work from others that was omitted due to space limitations. A.B.C. is supported by grants from the NIH (R01 DK098448 and R01 HL130793).

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  1. Division of Pediatric Hematology-Oncology, Boston Children’s Hospital/Dana-Farber Cancer Institute, Harvard Medical School, 300 Longwood Ave. Karp 7, Boston, MA, 02115, USA

    Alan B. Cantor

  2. Harvard Stem Cell Institute, Cambridge, MA, 02138, USA

    Alan B. Cantor

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Correspondence to Alan B. Cantor .

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  1. Institute of Experimental Biomedicine I, University Hospital Würzburg, Würzburg, Germany

    Harald Schulze

  2. Vascular Biology Programm, Harvard Medical School, Boston, Massachusetts, USA

    Joseph Italiano

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Cantor, A.B. (2016). Megakaryocytic Transcription Factors in Disease and Leukemia. In: Schulze, H., Italiano, J. (eds) Molecular and Cellular Biology of Platelet Formation. Springer, Cham. https://doi.org/10.1007/978-3-319-39562-3_3

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