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Thrombophilia and Thrombocytopenia in the Pregnant Woman

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Medical Problems During Pregnancy

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Abstract

Pregnant women face hemostatic challenges during labor and delivery. However, a subset of this population will additionally face an increased risk of thromboembolic events secondary to inherited or acquired risk factors during the prepartum or postpartum period. Pregnancy itself, because of changes in the coagulation cascade and anatomic factors, represents a state of heighted risk for clotting events. Who should receive anticoagulants, at what dose, and for how long are frequent issues that arise when dealing with a patient at increased risk for thromboembolism during pregnancy. Another common hematologic condition during pregnancy is thrombocytopenia which frequently can be categorized as a benign, gestational thrombocytopenia, but other more serious conditions such as idiopathic thrombocytopenia purpura or thrombotic thrombocytopenic purpura should be considered. Here we discuss the risk of vascular thromboembolism in various inherited and acquired thrombophilias and their management during pregnancy as well as the differential diagnosis of thrombocytopenia in the pregnant woman with discussion on the management.

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  1. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Lourdes M. Mendez, Anish V. Sharda & Jeffrey I. Zwicker

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  1. Lourdes M. Mendez
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  2. Anish V. Sharda
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  1. Department of Neurology, Brigham and Womens Hospital, Boston, Massachusetts, USA

    Carolyn Bernstein

  2. Boston Maternal Fetal Medicine, Brookline, Massachusetts, USA

    Tamara C. Takoudes

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Mendez, L.M., Sharda, A.V., Zwicker, J.I. (2017). Thrombophilia and Thrombocytopenia in the Pregnant Woman. In: Bernstein, C., Takoudes, T. (eds) Medical Problems During Pregnancy. Springer, Cham. https://doi.org/10.1007/978-3-319-39328-5_4

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