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Acute Promyelocytic Leukaemia: Epigenetic Function of the PML-RARα Oncogene

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Abstract

Acute promyelocytic leukaemia is a myeloid neoplasm characterized by expansion of promyelocytic progenitors. Its main driver is the oncogenic fusion protein generated by the (t15;17) chromosomal translocation between the promyelocytic leukaemia (PML) and retinoic acid receptor α (RARα) genes. Being PML-RARα the primary trigger of APL, it represents an excellent model to study neoplastic transformation in the haematopoietic system. Importantly, epigenetic changes imposed by and/or associated with PML-RARα have been implicated not only in promoting/sustaining the tumour phenotype, but also in influencing therapy response. In this chapter we will discuss the existing literature on chromatin remodelling driven by PML-RARα and its impact on APL pathogenesis and therapy.

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Acknowledgements

We thank our collaborator Hugues de The for support and critical discussion. PS lab is supported by the Worldwide Cancer Research, the European Research Council, Medical Research Council, The Brain Tumour Charity. JPH is recipient of a Research Fellowship from the Deutsche Forschungsgemeinschaft (German Research Foundation).

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  1. Samantha Dickson Brain Cancer Unit, University College London Cancer Institute, London, UK

    Julia P. Hofmann & Paolo Salomoni

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  1. Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

    David P. Bazett-Jones

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Hofmann, J.P., Salomoni, P. (2016). Acute Promyelocytic Leukaemia: Epigenetic Function of the PML-RARα Oncogene. In: Bazett-Jones, D., Dellaire, G. (eds) The Functional Nucleus. Springer, Cham. https://doi.org/10.1007/978-3-319-38882-3_4

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