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Manipulation of PML Nuclear Bodies and DNA Damage Responses by DNA Viruses

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The Functional Nucleus

Abstract

To undergo a successful infection, viruses must overcome intrinsic host responses that would otherwise suppress their gene expression or replication. For nuclear viruses, these host responses include promyelocytic leukemia (PML) nuclear bodies (NBs) and DNA damage responses (DDR). DNA viruses have been found to be particularly adept at disabling PML NBs and DDRs in order to overcome their inhibitory effects on viral infection. In addition, DNA viruses often induce and use components of the DDR to augment their own replication. Studying the interplay between viruses and PML NBs and DDRs has been hugely informative in understanding the regulation of these cellular structures and responses and their associated functions. Here we discuss the multiple mechanisms by which DNA viruses manipulate PML NBs and DDRs.

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Acknowledgements

Work in the Frappier laboratory is supported by grants from the Canadian Institutes of Health Research (CIHR) and the Canadian Cancer Society. L.F. is a tier 1 Canada Research Chair in Molecular Virology.

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  1. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

    Lori Frappier

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  1. Lori Frappier
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Correspondence to Lori Frappier .

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  1. Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

    David P. Bazett-Jones

  2. Dalhousie University, Halifax, Nova Scotia, Canada

    Graham Dellaire

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Frappier, L. (2016). Manipulation of PML Nuclear Bodies and DNA Damage Responses by DNA Viruses. In: Bazett-Jones, D., Dellaire, G. (eds) The Functional Nucleus. Springer, Cham. https://doi.org/10.1007/978-3-319-38882-3_13

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