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Hyperhidrosis

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Dermatology in Public Health Environments

Abstract

Hyperhidrosis is defined as sweating amounts larger than necessary to maintain normal body thermoregulation. This condition can affect the patient’s quality of life by way of its psychological and social impact. The central nervous system (cortex, hypothalamus, medulla) and sweat glands, including the eccrine, apocrine, and apoeccrine, are involved in the physiopathology of this condition. Hyperhidrosis can be divided into primary and secondary, and is also associated with a wide variety of conditions. Treatments to alleviate this disorder include topical products (aluminum compounds), iontophoresis, oral treatment with anticholinergic agents (glycopyrrolate, clonidine, oxybutynin), and interventional procedures such as botulinum toxin A, sweat gland removal (suction or curettage), microfocused ultrasound, and sympathectomy. Understanding the clinical features of this disorder and treatment modalities is vital to the optimization of treatment for affected patients.

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Authors and Affiliations

  1. Brazilian Center for Studies in Dermatology, Porto Alegre, Brazil

    Doris Hexsel & Fernanda Oliveira Camozzato

  2. Hexsel Dermatology Clinic, Porto Alegre, Rio de Janeiro, Brazil

    Doris Hexsel

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  1. Doris Hexsel
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  2. Fernanda Oliveira Camozzato
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Correspondence to Doris Hexsel .

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Editors and Affiliations

  1. Dermatology Service of Clinical, Hospital of Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil

    Renan Rangel Bonamigo

  2. Health Secretary of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Sergio Ivan Torres Dornelles

Glossary

Apocrine sweat glands 

Larger sweat glands that occur in hair follicles. They appear after puberty.

Apoeccrine sweat glands 

Contain morphological features common to the eccrine and apocrine sweat glands.

Eccrine sweat glands 

Small sweat glands that produce a fluid secretion without removing cytoplasm from the secreting cells and that are restricted to the human skin.

Hyperhidrosis 

Sweating greater than necessary for the maintenance of normal body thermoregulation.

Primary hyperhidrosis 

Excessive sweating in specific regions of the body and not caused by other medical conditions or by medications.

Secondary hyperhidrosis 

Excessive sweating caused by medications or medical conditions.

Sympathectomy 

Procedures that break the sympathetic innervation, thereby blocking stimulation of eccrine glands.

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Hexsel, D., Camozzato, F.O. (2018). Hyperhidrosis. In: Bonamigo, R., Dornelles, S. (eds) Dermatology in Public Health Environments. Springer, Cham. https://doi.org/10.1007/978-3-319-33919-1_67

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