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Adverse Effects of NSAIDs in the Gastrointestinal Tract: Risk Factors of Gastrointestinal Toxicity with NSAIDs

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NSAIDs and Aspirin

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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) belong to a class of drugs that has potent analgesic and anti-inflammatory effects. They act mainly by inhibiting cyclooxygenase (COX) enzymes including COX-1 and COX-2, which are involved in prostaglandin synthesis. This class of medications includes the traditional, non-selective NSAIDs that inhibit both COX-1 and COX-2, and the newer selective COX-2 inhibitors. They are highly effective in treating various painful conditions such as osteoarthritis and dysmenorrhoea. Unlike other NSAIDs, aspirin is used primarily for its anti-platelet effect to reduce cardiothrombotic risks.

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  1. Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Science, and Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, Hong Kong, China

    Sunny H. Wong M.B.Ch.B. (Hons.), D.Phil. & Francis K. L. Chan M.D., D.Sc.

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  1. Sunny H. Wong M.B.Ch.B. (Hons.), D.Phil.
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  2. Francis K. L. Chan M.D., D.Sc.
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Correspondence to Francis K. L. Chan M.D., D.Sc. .

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  1. IIS Aragón, CIBER Enfermedades Hepáicas y Digestivas (CIBERehd), Universidad de Zaragoza, Zaragoza, Spain

    Angel Lanas

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Wong, S.H., Chan, F.K.L. (2016). Adverse Effects of NSAIDs in the Gastrointestinal Tract: Risk Factors of Gastrointestinal Toxicity with NSAIDs. In: Lanas, A. (eds) NSAIDs and Aspirin. Springer, Cham. https://doi.org/10.1007/978-3-319-33889-7_4

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