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Infective Endocarditis

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Geriatric Diseases

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Abstract

The epidemiology of infective endocarditis (IE) is changing for several reasons. The older patients are at a high risk of contracting IE due greatly to increased prevalence in patients with inbody cardiac devices. The microbiology of the disease has also changed from streptococcus to healthcare-associated staphylococcus. Recently, many studies have shown a trend towards increasing incidence of Staphylococcus aureus IE. IE in the elderly caused less severe symptoms than in the young. Non-specific generalized symptoms, myalgias, arthralgias, malaise, fatigue, loss of weight and sweats, are also common though rigours are much more common in acute IE. Embolism and immune-mediated phenomena are common in the elderly. The protean nature of IE requires a diagnostic strategy that will be sensitive for disease detection and specific for its exclusion across all forms of the disease. Successful outcome will depend on early diagnosis, effective treatment and timely recognition of complications. The mortality of prosthetic IE caused by Staphylococcus aureus treated medically is 75%, and in the case of medical plus surgical treatment, it is 25%.

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References

  1. Durante-Mangoni E, Bradley S, Selton-Suty C, Tripodi MF, Basic B, Bouza E, et al. Current features of infective endocarditis in elderly patients: results of the International Collaboration on Endocarditis Prospective Cohort Study. Arch Intern Med. 2008;168:2095–103.

    Article  PubMed  Google Scholar 

  2. Slipczuk L, Codoloa JN,Davik CD, Romero-Corra A, Yun J, Gregg S, et al. Infective endocarditis: Epidemiology over 5 decades. A Systematic review. PLOS/one. https://doi.org/10.1371/journal.pone.0082665

  3. Cahill TJ, Prendergast BD. Infective endocarditis. The Lancet. 2016;387(10021):882–893.

    Article  Google Scholar 

  4. Werdani K, Dietz S, Loffler B, Niemann S, Bushnaq H, Silber R-E, et al. Mechanisms of infective endocarditis: pathogen-host interaction and risk states. Nature Rev Cardiol. 2014;11:35–50.

    Article  Google Scholar 

  5. Gergoratos G. Infective endocarditis in the elderly: diagnosis and management. Am J Geriat Cardiol. 2003;12:183–89.

    Article  Google Scholar 

  6. Hill EE, Herijgers P, Herregods MC, Peetermans WE. Evolving trends in infective endocarditis. Clin Microbiol Infect. 2006;12:5–12.

    Article  CAS  PubMed  Google Scholar 

  7. Fernandez-Hidalgo N, Almirante B, Tomos P, Pigrau C, Sambola A, et al. Contemporary epidemiology and prognosis of health care-associated infective endocarditis. Clin Infect Dis. 2008;47:1287–1297.

    Article  PubMed  Google Scholar 

  8. Benito N, Miro JM, de Lazzari E, Cabell CH, Del Rio A, Altolas J, et al. Health care-associated native valve endocarditis: importance of non-nosocomial acquisition. Ann Int Med 2009;150:586–594.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Vahanian A. The growing burden of infective endocarditis in the elderly. Eur Heart J.2003;24:1539–1590

    Article  CAS  PubMed  Google Scholar 

  10. Hoen B, Alla F, Selton-Suty CH, Beguinot I, Bouvet A, Briangon S, et al. Changing profile of infective endocarditis. Results of a 1 year survey in France. JAMA. 2002;228:75–81.

    Article  Google Scholar 

  11. Dhawan VK, Infective endocarditis in elderly patients. Clin Infect Dis. 2002;34(6):806–812.

    Article  PubMed  Google Scholar 

  12. Brusch J. Infective endocarditis: Management in the case of intravascular devices. New York. NY. Informa Health Care. 2007.

    Book  Google Scholar 

  13. Cunha RA, Gill MV, Lazar IM Acute infective endocarditis. Diagnostic and therapeutic approach. Infect Dis Clin North Am 1996;10:811–34.

    Article  CAS  PubMed  Google Scholar 

  14. Murdoch DR, Corey GR, Hoen B, Miro JM, Fowler VG Jr,Bayer AS et al. Clinical presentation and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study. Arch Intern Med. 2009;169:463–473.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Fowler VG Jr, Miro JM, Hoen B, Cabell CH, Abruytn E, Rubenstein E, et al. Staphylococcus aureus endocarditis: a consequence of medical progress. JAMA. 2005;293:3012–3021.

    Article  CAS  PubMed  Google Scholar 

  16. Werner GS, Schulz R, Fuchs JB, Andrenas S, Prange H, Ruschewski W, et al. Infective endocarditis in the elderly in the era of transesophageal echocardiography: clinical features and prognosis compared with younger patients. Am J Med. 1996;100:90–97.

    Article  CAS  PubMed  Google Scholar 

  17. Bayer A Bolger AF, Taubert KA, Wilson W, Steckelberg J, Karchmer AW, et al. Diagnosis and management of infective endocarditis and its complications. Circulation. 1998;98:2936–2948.

    Article  CAS  PubMed  Google Scholar 

  18. Di Salvo G, Rosenberg V, Pergola V, Belliard O, Derumeaux G, Cohen A, et al. Endocarditis in the elderly: clinical, echocardiographic, and prognostic features. Eur Heart J. 2003;24:1575–1582.

    Article  Google Scholar 

  19. Selton-Suty C, Hoen B, Grentzinger A, Houplon P, Maignan M Juilliere Y, et al. Clinical and bacterial characteristics of infective endocarditis in the elderly. Heart 1997;77:260–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Piper C, Korfer R, Horstkotte D. Prosthetic valve endocarditis. Heart. 2002 8590–593.593.

    Google Scholar 

  21. Durack DT, Karchmer AW. Infective endocarditis: clinical presentation. APC Medicine Online 2006. www.medscape.com/viewarticle/534843

  22. Terpenning MS, Buggy BP, Kaufman CA. Infective endocarditis: clinical features in young and elderly patients. Am J Med. 1987;83:626–634.

    Article  CAS  PubMed  Google Scholar 

  23. Kaye D. Infective endocarditis. 2 New York:Raven,1992.

    Google Scholar 

  24. Health Article: Infective endocarditis. website www.new-health-articles.com/category/infective-endocarditis

  25. Lopez-Wolf D, Vilacosta I, San Roman JA, Fernandez C, Sarna C, Lopez J, et al. Infective endocarditis in octogenarian patients Rev Esp Cardiol. 2011;64:329–33.

    Article  PubMed  Google Scholar 

  26. Cunha BA, Johnson DH, Klein NC. Infective endocarditis. http://wiserwiki.com/Infective_Endocardits retrieved on 17 December 2007.

  27. Bush LM, Johnson CC. Clinical syndrome and diagnosis. D Kaye Infective endocarditis 2. New York:Raven;1992:99–113.

    Google Scholar 

  28. Bayer AS. Infective endocarditis. Clin Infect Dis. 1993;17:313–320.

    Article  CAS  PubMed  Google Scholar 

  29. Miro JM, del Rio, Mestres CA. Infective endocarditis in intravenous drug abusers and HIV-1 infected patients. Infect Dis Clin North Am. 2002;16:273–295.295.

    Article  PubMed  Google Scholar 

  30. Prendergast BD.The changing face of infective endocarditis. Heart. 2006;92(7):879–885.

    Article  CAS  PubMed  Google Scholar 

  31. Huang T-Y, Tseng H-K, Liu C-P, Lee C-M. Comparison of the clinical manifestations of infective endocarditis between elderly and young patients- q3-year study. J Microbiol Immunol Infect. 209;42:154–159.

    Google Scholar 

  32. Van Reyn CF, Arbitt RY. Cause definitions for infective endocarditis. Am J Med 1994;96:220–282.

    Article  Google Scholar 

  33. Washingtoon JH. The microbiologic diagnosis of infective endocarditis. J Antimicrob Chemothera. 1987;20 (suppl A):29–36.

    Article  Google Scholar 

  34. Tunkel AR, Kaye D. Endocarditis with negative blood culture. NEJM. 1992;326:1215–1217.

    Article  CAS  PubMed  Google Scholar 

  35. Durack DT, Lukes AS, Bright DK. New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service. Am J Med. 1994;96(3):200–9.

    Article  CAS  PubMed  Google Scholar 

  36. Li JS, Sexton DI, Mick N, Nettles R, Fowler VG Jr, Ryan T, et al. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis. 2000;30:633–8.

    Article  CAS  PubMed  Google Scholar 

  37. Shivly BK,Gurule FT, Roldan CA, Legett JH, Schiller NB. Diagnostic value of transoesophageal compared with trans thoracic echocardiography in infective endocarditis. J Am Coll Cardiol. 1991;18:391–397.

    Article  Google Scholar 

  38. Muggee A, Daniel WG, Frank G, Lichtlen PR. Echocardiography in infective endocarditis: reassessment of prognostic implications of vegetation size determined by transthoracic and the transoesophageal approach. J Am Coll Cardiol. 1989:14:631–638.

    Article  Google Scholar 

  39. Shapiro SM,Young E, De Guzman S, Ward J, Chiu CY, Ginzion LE, et al. Transoesophageal echocardiography in diagnosis of infective endocarditis. Chest. 1994;105:377–382.

    Article  CAS  PubMed  Google Scholar 

  40. Daniel WG, Mugge A, Grote J, Hausmann D, Nikutta P, Laas J, et al. Comparison of transthoracic and transoesophageal echocardiography for detection of abnormalities of prosthetic and bioprosthetic valves in the mitral and aortic positions. Am J Cardiol. 1993;71:210–215.

    Article  CAS  PubMed  Google Scholar 

  41. Rohmann S ,Seifer T, Erbel R,Jakob H, Mohr-Kahely S, Makowski T, et al. Identification of abscess formation in native-valve infective endocarditis using transoesophageal echocardiography: implications for surgical treatment. Thorac Cardiovasc Surg. 1991;39:273–280.

    Article  CAS  PubMed  Google Scholar 

  42. Karalis DG, Bansal RC, Hauck AJ, Ross JJ Jr, Applegate PM, Jutzy KR, et al. Transoesophageal echocardiograpic recognition of subaortic complications in aortic valve endocarditis: clinical and surgical implications. Circulation. 1992;86:353–362.

    Article  CAS  PubMed  Google Scholar 

  43. Ali AS, Trivedi V, Lesch M. Culture negative endocarditis: a historical review and 1990s update. Prog Cardiovasc Dis. 1994;37:149–160.

    Article  CAS  PubMed  Google Scholar 

  44. Wilson WR, Karchmer AW, Dajani AS, Taubert KA, Bayer A, Kaye D, et al. Antibiotic treatment of adults with infective endocarditis due to streptococci, enterococci, staphylococci and HACEK microorganisms. JAMA. 1995;274:1706–1713.

    Article  CAS  PubMed  Google Scholar 

  45. Pettersson C. surgery for Infective endocarditis. Cleveland Clinic. http://my.clevelandclinic.org/heart/disorders/valve/sbesurgery/aspx.

  46. Delahaye F, Cetard M, Roth O, de Gevigney G. Indications and optimal timing for surgery in infective endocarditis. Heart. 2004;90:618–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Di Salva G, Habib G,Pergola V, Avierinos JF, Phillip E, Casalta JP, et al. Echocardiography predicts embolic events in infective endocarditis. J Am Coll Cardiol. 2001;37:7069–76.

    Google Scholar 

  48. Heiro M, Nikokelainen J, Engblom E, Kotilanien E, Martila R, Kotilanien P, et al. Neurological manifestations of infective endocarditis: a 17-year experience in a teaching hospital in Finland. Arch Intern Med. 2000;160:2781–7.

    Article  CAS  PubMed  Google Scholar 

  49. John MD, Hibberd P, Karchmer AW, Sleeper LA, Calderwood SB. Staphylococcus aureus prosthetic valve endocarditis: optimal management and risk factors for death. Clin Infect Dis. 1996;26:1302–9.

    Article  Google Scholar 

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Authors and Affiliations

  1. The University of Sydney, Westmead Clinical School, Westmead, NSW, Australia

    Nages Nagaratnam & Kujan Nagaratnam

  2. Rehabilitation and Aged Care Service, Blacktown-Mt Druitt Hospital, Mount Druitt, NSW, Australia

    Gary Cheuk

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  1. Nages Nagaratnam
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  2. Kujan Nagaratnam
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  3. Gary Cheuk
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Nagaratnam, N., Nagaratnam, K., Cheuk, G. (2018). Infective Endocarditis. In: Geriatric Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-33434-9_7

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  • DOI: https://doi.org/10.1007/978-3-319-33434-9_7

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  • Print ISBN: 978-3-319-33433-2

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