Abstract
The incidence of gout seems to be rising in the elderly, both in men and women in countries where the life expectancy is lengthening and the frequency of overuse of diuretics. Gout predominantly affects the middle ages and elderly people and rarely occurs in young adult or children. CPPD crystal deposition disease is the second most common form of crystal-induced arthritis and is common in the elderly. The chapter discusses the pathogenesis of gout and clinical management.
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References
Eggebeen AT. Gout: an update. Am Fam Physician. 2007;76:801–8.
De Leonardis F, Govoni M, Colina M, Bruschi M, Trotta F, Elderly-onset gout: a review. Rheumat Int. 2007;28:1–6.
Fam AG. Gout in the elderly: Clinical presentation and treatment. Drugs Aging. 1998;13:229–243.
Staessen J. The determination and prognostic significance of serum uric acid in elderly patients of the European Working Party high blood pressure on the Elderly trial. Am J Med. 1999;90(3A):50S–54S.
Choi HK, Atkinson K, Karlson EW, Curhan G. Obesity, weight changes, hypertension, diuretic use and risk of gout in men: the health professional follow-up study. Arch Intern Med. 2005;165:742–8.
Arromdee E, Michet CJ, Growson CS, Fallon S, Gabriel SE. Epidemiology of gout: Is the incidence rising? J Reumatol. 2002;29:2403–6.
Mikuls TR, Farrar JT, Bilker WNB, Fernsndes S, Schumacher HR Jr, Saag KG. Gout epidemiology: Results from the United Kingdom general practice research data base. 1990–1999. Ann Rheum Dis. 2005;64:267–272.
Matsuo H, Ichida K, Takada T, Nakayama A, Nakashima H, Nakamura T, et al. Common dysfunctional variants in ABCG2 are a major cause of early-onset gout. Sci Rep. 2013;3:2014. https://doi.org/10.1038/srep02114.
Schlesinger N, Thiele RG. The pathogenesis of bone erosions in gouty arthritis. Ann Rheum Dis. 2010; 69:1907–1912.
Ea HK. Mechanisms of gout inflammation. PreseMed. 2011;40(9Pt1):836–43.
Rider TG, Jordan KM. The modern management of gout. Rheumatology (Oxford). 2010;49(1):5–14.
Cronstein BN, Terkaltaub R. The inflammatory process of gout and its treatment. Arthritis Res. Ther. 2006;8:S1.
Petrillie V, Martinn P. The inflammasome acute inflammatory diseases and gout. Joint Bone Spine. 2007;74:571–6.
Martinon V, Petrilli A, Mayor A, Tardivel A, Tschopp J. Gout associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;44092081):237–241.
Choi HK, Mpunt DB, Reginato AM. Pathogenesis of gout. Ann Intern Med. 2005;143:499–51616.
Graessler J, Graessle A., Unger S, Kopprsch S, Tausche AK, Kuhlisch E, et al. Association of human urate transporter-1 with reduced renal uric acid excretion and hyperuraecaemia in a German Caucasian population. Arthritis Rheum. 2006;54:292–300.
Dalbeth N, Merriman T. Crystal ball gazing: new therapeutic targets for hyperuraecaemia and got. Rheumatology. 2009;48:222–6.
Julkunen H, Konttinen YT. The clinical picture of gout is changing. Duodecim. 2010;126(12):1477–85.
Ter Borg EJ, Rasker JJ. Gout in the elderly: a separate entity? Ann Rheum Dis. 1987;46:72–76.
Doherty M, Dieppe P. Crystal deposition in the elderly. Clin Rheum Dis. 1986;12:97–116.
Centers for Disease Control and Prevention. Gout. http://www.cdc.gov/arthritis/basics/gout.htm retrieved 6 March 2015.
Rott KJ, Agudedo CA. Gout. JAMA. 2003;289:2857–2860.
Yu T. Gout. In Katz WA ed. Diseases and Management of Rheumatic Diseases, ed. 2. Philadelphia. Lippincott Comp. 1988, pp 544–561.
Pittman JR, Bross MH. Diagnosis and management of gout. Am Fam Physician. 1999;59(7):1799–1806.
McQueen FM, Reeves Q, Dalbeth N. New insights in an old disease: advanced imaging in the diagnosis and management of gout. Postgrad Med J. 2013;89;87–93.
Chowalloor PV, Siew TK, Keen HI. Imaging in gout. A review of recent developments. Ther Adv Musculoskelet Dis. 2014;8(4):136–143.
Thiele RG, Schlesinger N. Diagnosis of gout by ultrasound. Rheumatology. 2007;46:1116–21.
Lai K, Chiu Y. Role of ultrasonography in diagnosing gouty arthritis. J Med Ultrasound. 2011;19:7–13.
McQueen FM, Doyle A, Dalbeth N. Imaging in gout-what can we learn from MRI, CT, DECT and US? Arthritis Res Ther. 2011;13:246.
Schlesinger N. Management of acute and chronic gouty arthritis: present state of the art. Drugs. 2004;64(21):2399–416.
Cavagna L, Taylor WJ. The emerging role of biotechnological drugs in the treatment of gout. Biomed Res Int. 2014;2014:264859. https://doi.org/10.1155/2014/264859.
Wechalekar MD, Vinil O, Schlesnger N, Buchbinder R. Intra-articular of glucocorticoids for acute gout. Cochrane Database System, Rev 2011, https://doi.org/10.10002/1415185.cD009920.part2.
McGill N. Management of acute gout. Aust Prescr. 2004;27:10–3.
Khanna D, Khanna PB, Fitzgerald JD, Singh MK, Sangmee BAE, Neogi T et al. American College of Rheumatology. Guidelines and management of gout. Part 2 Therapy antiinflammatory prophylaxis of acute gouty arthritis. Arthritis Care Res. 2012;64(10): 1447–1461.
Daoussis D, Antonopoulos I, Yiannopoulos G, Andonopoulos AP. ACTH as first line treatment for acute gout in 181 hospitalized patients. Joint Bone Spine. 2013;80(3):291–4.
Morris I, Varughese G, Mattingly P. Lesson of the week-Colchicine in acute gout. BMJ. 2001;13:240–244.
Richette P. Gout: an overview of available urate lowering therapies. Ann Pharm Fr. 2012;70(3):33–8.
George L, Sudy JS. Pegloticase for treating refractory chronic gout. Drugs Today (Brc). 2012;48(7):441–9.
Suresh E, Das P. Recent advances in management of gout. QJM. 2012;105(5):407–17.
Globalrph Gout treatment/Elevated uric acid levels. http://www.globalrph.com/gout.htm. accessed 7 March 2015.
Avena-Woods C, Hilas O. Febuxostat (Uloric). A new treatment option for gout. Journal List. PT.v35(2);2010. PMC 2827920.
Steika BS, May J. New gout managing guidelines: A quick and easy guide. Medscape. http://www.medscape.com/features/slideshow/gout#4 accessed 4 March 2015.
Lindsay K, Gow P, Vanderpyl J, Logo P, Dalbeth N. The experience and impact of living with gout: a study of men with chronic gout using a qualitative grounded theory approach. J Clin Rheumatol. 2011;17(1):1–6.
Singh JA. The impact of gout on patient’s lives: a study of African-American and Caucasian men and women with gout. Arthritis Res Ther. 2014;16:R132.
Khanna PP, Nuli G, Bardon T, Tauschi AK, Forsyth A, Goven A, et al. Tophi and frequent gout flares are associated: quality of life, productivity sand increased health care costs resource use: Results from a cross sectional survey. Health Quality Outcomes. 2012;10:117.
Roddy Z, Zhang W, Doherty M. Is gout associated with reduced quality of life? A case – control study. Rheumatology (Oxford). 2007;46:1441–1444.
Shields E, Besrd SM. A systematic review of the economic and humanistic burden of gout. Pharmacoeconomics. 2015. https://doi.org/10.1007/s40273-015-0288-5.
Smith E, Hoy D, Crooss M, Merriman TR, Vos T, Buchbinder R, Woolf A, et al. The global burden of gout: estimates from the Global Burden of Disease. 2010 study. Ann Rheum Dis. 2014;73(8):1470–6.
McCarty DJ. Crystal induced arthritis. Dis Mon 1994;40(6):255–59.
George RL Jr, Sundy JS. Pegloticase for treating refractory gout. Drugs Today (Barc). 2012;48(7):441–9.
Winzer M, Grassler J, Aringer M. Crystal-induced arthritis-old but important. Z Rheumatol. 2007;66:317–74.
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Nagaratnam, N., Nagaratnam, K., Cheuk, G. (2018). Crystal-Induced Arthritis. In: Geriatric Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-33434-9_57
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DOI: https://doi.org/10.1007/978-3-319-33434-9_57
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