Skip to main content
SpringerLink
Log in

Pleomorphic Xanthoastrocytoma

  • Chapter
  • First Online:
Atlas of Pediatric Brain Tumors

Abstract

Pleomorphic xanthoastrocytoma (PXA) is an uncommon astrocytic lesion that—despite its significant histologic pleomorphism—generally behaves in a less aggressive fashion than similarly pleomorphic infiltrative gliomas; its behavior affords it a World Health Organization (WHO) grade II designation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Suggested Reading

  • Chamberlain MC. Salvage therapy with BRAF inhibitors for recurrent pleomorphic xanthoastrocytoma: a retrospective case series. J Neurooncol. 2013;114:237–40.

    Article  CAS  PubMed  Google Scholar 

  • Crespo-Rodriguez AM, Smirniotopoulos JG, Rushing EJ. MR and CT imaging of 24 pleomorphic xanthoastrocytomas (PXA) and a review of the literature. Neuroradiology. 2007;49:307–15.

    Article  PubMed  Google Scholar 

  • Dias-Santagata D, Lam Q, Vernovsky K, Vena N, Lennerz JK, Borger DR, et al. BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications. PLoS One. 2011;6:e17948.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fouladi M, Jenkins JJ, Burger PC, Langston J, Merchant T, Heideman R, et al. Pleomorphic xanthoastrocytoma: favorable outcome after complete surgical resection. Neuro Oncol. 2001;3:184–92.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Giannini C, Hebrink D, Scheithauer BW, Dei Tos AP, James CD. Analysis of p53 mutation and expression in pleomorphic xanthoastrocytoma. Neurogenetics. 2001;3:159–62.

    Article  CAS  PubMed  Google Scholar 

  • Giannini C, Scheithauer BW, Lopes MB, Hirose T, Kros JM, VandenBerg SR. Immunophenotype of pleomorphic xanthoastrocytoma. Am J Surg Pathol. 2002;26:479–85.

    Article  PubMed  Google Scholar 

  • Goncalves VT, Reis F, Queiroz LS, Franca Jr M. Pleomorphic xanthoastrocytoma: magnetic resonance imaging findings in a series of cases with histopathological confirmation. Arq Neuropsiquiatr. 2013;71:35–9.

    Article  PubMed  Google Scholar 

  • Hirose T, Giannini C, Scheithauer BW. Ultrastructural features of pleomorphic xanthoastrocytoma: a comparative study with glioblastoma multiforme. Ultrastruct Pathol. 2001;25:469–78.

    Article  CAS  PubMed  Google Scholar 

  • Hirose T, Ishizawa K, Sugiyama K, Kageji T, Ueki K, Kannuki S. Pleomorphic xanthoastrocytoma: a comparative pathological study between conventional and anaplastic types. Histopathology. 2008;52:183–93.

    Article  CAS  PubMed  Google Scholar 

  • Ida CM, Vrana JA, Rodriguez FJ, Jentoft ME, Caron AA, Jenkins SM, et al. Immunohistochemistry is highly sensitive and specific for detection of BRAF V600E mutation in pleomorphic xanthoastrocytoma. Acta Neuropathol Commun. 2013;1:20.

    Article  PubMed  PubMed Central  Google Scholar 

  • Koelsche C, Sahm F, Wohrer A, Jeibmann A, Schittenhelm J, Kohlhof P, et al. BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression. Brain Pathol. 2014;24:221–9.

    Article  CAS  PubMed  Google Scholar 

  • Lacoste-Collin L, d'Aure D, Aziza J, Quintyn ML, Uro-Coste E, Courtade-Saidi M. Cerebrospinal fluid cytologic findings of a pleomorphic xanthoastrocytoma: a case report. Acta Cytol. 2010;54:871–4.

    PubMed  Google Scholar 

  • Perkins SM, Mitra N, Fei W, Shinohara ET. Patterns of care and outcomes of patients with pleomorphic xanthoastrocytoma: a SEER analysis. J Neurooncol. 2012;110:99–104.

    Article  PubMed  Google Scholar 

  • Rao AA, Laack NN, Giannini C, Wetmore C. Pleomorphic xanthoastrocytoma in children and adolescents. Pediatr Blood Cancer. 2010;55:290–4.

    Article  PubMed  Google Scholar 

  • Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold-Mende C, et al. Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol. 2011;121:397–405.

    Article  CAS  PubMed  Google Scholar 

  • Weber RG, Hoischen A, Ehrler M, Zipper P, Kaulich K, Blaschke B, et al. Frequent loss of chromosome 9, homozygous CDKN2A/p14(ARF)/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytoma. Oncogene. 2007;26:1088–97.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave., MLC 1035, Cincinnati, OH, 45229-3026, USA

    Christine E. Fuller M.D.

Authors
  1. Christine E. Fuller M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Christine E. Fuller M.D. .

Editor information

Editors and Affiliations

  1. Department of Pathology, Texas Children’s Hospital Baylor College of Medicine, Houston, Texas, USA

    Adekunle M. Adesina

  2. Department of Pathology, Neuropathology Division, San Francisco, California, USA

    Tarik Tihan

  3. Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, Virgin Islands, USA

    Christine E. Fuller

  4. PBTC Neuroimaging Center, Harvard Medical School, Boston, Massachusetts, USA

    Tina Young Poussaint

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing AG

About this chapter

Cite this chapter

Fuller, C.E. (2016). Pleomorphic Xanthoastrocytoma. In: Adesina, A., Tihan, T., Fuller, C., Poussaint, T. (eds) Atlas of Pediatric Brain Tumors. Springer, Cham. https://doi.org/10.1007/978-3-319-33432-5_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-33432-5_3

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-33430-1

  • Online ISBN: 978-3-319-33432-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation