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Selection and Application of Aptamers and Intramers

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Protein Targeting Compounds

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 917))

Abstract

Aptamers are auspicious nucleic acid ligands for targeting different molecules, such as small molecules, peptides, proteins, or even whole living cells. They are short single-stranded DNA or RNA oligonucleotides, which can fold into complex three-dimensional structures and bind selectively their targets. Using the combinatorial chemistry process SELEX (Systematic Evolution of Ligands by EXponential Enrichment), target specific aptamers can be selected. These aptamers have a variety of application possibilities and can be used as sensors, diagnostic, imaging or therapeutic agents, and in the field of regenerative medicine for tissue engineering.

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Authors and Affiliations

  1. Department of Thoracic and Cardiovascular Surgery, University Hospital Tuebingen, Calwerstr. 7/1, 72076, Tuebingen, Germany

    Meltem Avci-Adali

  2. RiNA GmbH, Berlin, Germany

    Meltem Avci-Adali

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  1. Meltem Avci-Adali
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Correspondence to Meltem Avci-Adali .

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  1. Recombinant protein exprsn/Intrabdy unit, Helmholtz-Centre for Infection Rese, Braunschweig, Germany

    Thomas Böldicke

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Avci-Adali, M. (2016). Selection and Application of Aptamers and Intramers. In: Böldicke, T. (eds) Protein Targeting Compounds. Advances in Experimental Medicine and Biology, vol 917. Springer, Cham. https://doi.org/10.1007/978-3-319-32805-8_11

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