Abstract
The paper aims at presenting and discussing some key points about the analysis of fetal heart rate (FHR) recorded by means of CardioTocography (CTG). Starting from a brief history of CTG computerized analysis, the paper describes how the integration of various computational methods for extracting reliable parameters from FHR variability can help the pre natal diagnosis.
The approaches adopted for the analysis are briefly illustrated, considering both traditional time domain parameters as well as new indices in the nonlinear field such as entropy measures, complexity parameters and indices derived from phase rectified signal averaging method. IUGR fetuses can be separated from Normal ones by parameters with high levels of significance. Moreover, collecting few of them allow obtaining classification models able to provide correct classification for more than 90% fetuses. Results obtained from Normal and IUGR populations of fetuses show that i) the integration of linear and nonlinear parameters provide reliable indications about pathophysiologic fetal states; ii) could support early clinical diagnosis of fetal pathologies; iii) should be considered to design novel fetal monitoring systems.
The original version of this chapter was inadvertently published with an incorrect chapter pagination 1199–1204 and DOI 10.1007/978-3-319-32703-7_232. The page range and the DOI has been re-assigned. The correct page range is 1205–1210 and the DOI is 10.1007/978-3-319-32703-7_233. The erratum to this chapter is available at DOI: 10.1007/978-3-319-32703-7_260
An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-32703-7_260
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References
J. De Haan, J. H. Vam Bemmel, B. Versteeg, A. F. L. Veth, L. A. M. Stolte, J. Janssens, and T. K. A. B.Eskes, “Quantitative evaluation of fetal heart rate. i. processing methods” Eur. J. Obstet. Gynaecol. 3, 95, 1971.
G.S. Dawes, M. Moulden, C.W.G. Redman, “System 8000: Computerized antenatal FHR analysis”, Journal of Perinatal Medicine, vol. 19 (1-2), pp. 47-51, 1991.
D. Arduini, G. Rizzo, G. Piana, A. Bonalumi, P. Brambilla, and C. Romanini, “Computerized analysis of fetal heart rate: I. description of the system (2CTG),” Matern. Fetal. Invest. 3, 159, 1993.
H. P. van Geijn, “Developments in CTG analysis,” Baillieres Clin. Obstet. Gynaecol., vol. 10, no. 2, pp. 185–209, 1996.
Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology, “Heart Rate Variability, Standards of Measurement, Physiological Interpretation and Clinical Use”, Circulation, 93, 1043–1065, 1996.
Goldberger AL1, Rigney DR, West BJ., Chaos and fractals in human physiology. Sci Am. 1990 Feb;262(2):42-9.
Mäkikallio TH, Seppänen T, Niemelä M, Airaksinen KE, Tulppo M, Huikuri HV.Abnormalities in beat to beat complexity of heart rate dynamics in patients with a previous myocardial infarction. J Am Coll Cardiol. 1996 Oct;28(4):1005-11
M.G. Signorini, G. Magenes, S. Cerutti, D. Arduini, “Linear and Nonlinear Parameters for the Analysis of Fetal Heart Rate Signal from Cardiotocographic Recordings”, IEEE Trans Biom Eng, 50(3), 365-375, 2003..
Nonlinear Analysis of Physiological Data edited by Holger Kantz, J. Kurths, Gottfried Mayer-Kress, Springer Verlag, Berlin Heidelberg, 1988.
S. M. Pincus, “Approximate entropy (ApEn) as complexity measure”, Chaos, 5(1), 110-117, 1995.
J. S. Richman and J. R. Moorman, “Physiological time-series analysis using approximate entropy and sample entropy”, Am J Physiol Heart Circ Physiol, 278, 2039-2049, 2000.
M. Costa, A. L. Goldberger, C-K Peng, “Multiscale entropy analysis of complex physiologic time series”, Phys Rev Lett, 89(6), 068102, 2002.
A. Lempel and J. Ziv, “On the complexity of finite sequences”, IEEE Transactions on Information Theory, 22, 75-81, 1976.
A. Bauer, A. Bunde, P. Barthel, R. Schneider, M. Malik, G. Schmidt, “Phase rectified signal averaging detects quasi-periodicities in non-stationary data”, J Phys A, vol. 364, pp. 423–434, 2006.
E. A. Huhn, S. Lobmaier, T. Fischer, R. Schneider, A. Bauer, K. T. Schneider and G. Schmidt, “New computerized fetal heart rate analysis for surveillance of intrauterine growth restriction”, Prenat Diagn, nn. 31, vol. 5, pp. 509-514, 2011.
A. Fanelli, G. Magenes, M. Campanile, M.G. Signorini, “Quantitative assessment of fetal well-being through CTG recordings: a new parameter based on Phase Rectified Signal Average”, IEEE Journal of Biomedical and Health Informatics, Sept 2013, Vol 17 (5), 959–966, 2013.
M. Ferrario, M. G. Signorini, G. Magenes, S. Cerutti, “Comparison of regularity estimators based on entropy measures: application to the Fetal Heart Rate signal for the identification of fetal distress” IEEE Trans Biomed Eng. 53(1), 119-125, 2006.
Magenes G, Signorini MG, Arduini D, Cerutti S. Fetal heart rate variability due to vibroacoustic stimulation: linear and nonlinear contribution. Methods Inf Med. 2004;43(1):47-51.
M. Ferrario, M.G. Signorini, G. Magenes, “Comparison between fetal heart rate standard parameters and complexity indexes for the identification of severe intrauterine growth restriction.”, Methods of Information in Medicine, 46 (2), 186-190, 2007.
M. Ferrario, M.G. Signorini, G. Magenes. “Complexity analysis of the fetal heart rate variability: early identification of severe intrauterine growth-restricted fetuses”. Med Biol Eng Comput. 47(9), 911-919, 2009
L. Demšar, T. Curk, A. Erjavec. Orange: Data Mining Toolbox in Python; Journal of Machine Learning Research 14(Aug):2349−2353, 2013.
Magenes G, Bellazzi R, Fanelli A, Signorini MG,.Multivariate analysis based on linear and non-linear FHR parameters for the identification of IUGR fetuses. Conf Proc IEEE Eng Med Biol Soc. 2014 Aug;2014:1868-71. doi: 10.1109/EMBC.2014.6943974. PMID: 25570342
G. Magenes, M.G. Signorini, M. Ferrario, F. Lunghi, “2CTG2: A new system for the antepartum analysis of fetal heart rate”, Chapter, 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007, Volume 16 of the series IFMBE Proceedings pp 781-784 (2007)
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Signorini, M.G., Magenes, G. (2016). Advanced Signal Processing Techniques for CTG Analysis. In: Kyriacou, E., Christofides, S., Pattichis, C. (eds) XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016. IFMBE Proceedings, vol 57. Springer, Cham. https://doi.org/10.1007/978-3-319-32703-7_233
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