Abstract
The measurement of glucose levels in patients under life-saving treatments, such as hemodialysis, is clinically important. In fact, during hemodialysis patients with type 2 diabetes may be at risk for hypoglycemic episodes. Even in non-diabetic patients, glycemia monitoring during hemodialysis is relevant, due for instance to its relationships with sodium (whose appropriate balance is crucial in hemodialysis). The measurement of glucose during hemodialysis can be performed with traditional methods, but this requires consumables, and operator intervention. Possible glucose measurement in the extracorporeal hemodialysis circuit (in plasma and/or dialysate) through optical methods may allow continuous and operator-free measurement. We aimed exploring the Near-Infrared approach, through a portable spectrometer. We analyzed deionized water samples at increasing glucose concentrations: 50, 100, 150, 200, 300, 500 mg/dl. For increased accuracy, we assessed separately the difference in transmittance between each pair of concentration values, with the lower value taken as reference. For each comparison, every experimental step was repeated twice and eventually average value taken. We used the DWARF-Star Miniature NIR Spectrometer by StellarNet, with detector for the 1000-1700 nm range. We found that the spectral range with more marked differences between the tested glucose concentrations was similar in each pair of concentration values: around 1300-1450 nm. The highest percentage transmittance difference was 3.44% in 50-100 mg/dl pair of values, 2.09% in 100-150, 1.80% in 150-200, 2.40% in 200-300, 3.44% in 300-500. Notably, these difference values were higher than the variability observed between the repeated measures performed for each glucose concentration. In conclusion, we showed that, with a portable, relatively inexpensive spectrometer, glucose concentration may be detected through variations in specific portions of the Near-Infrared band.
The original version of this chapter was inadvertently published with an incorrect chapter pagination 747–751 and DOI 10.1007/978-3-319-32703-7_145. The page range and the DOI has been re-assigned. The correct page range is 753–757 and the DOI is 10.1007/978-3-319-32703-7_146. The erratum to this chapter is available at DOI: 10.1007/978-3-319-32703-7_260
An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-32703-7_260
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References
Oh G, Anderson S, Tancredi D, Kuppermann N, Glaser N (2009) Hyponatremia in pediatric diabetic ketoacidosis: reevaluating the correction factor for hyperglycemia. Arch Pediatr Adolesc Med 163:771–772 DOI 10.1001/archpediatrics.2009.106
Hillier TA, Abbott RD, Barrett EJ (1999) Hyponatremia: evaluating the correction factor for hyperglycemia. Am J Med 106:399–403
Kashyap AS (1999) Hyperglycemia-induced hyponatremia: is it time to correct the correction factor? Arch Intern Med 159:2745–2746
Charra B (2007) Fluid balance, dry weight, and blood pressure in dialysis. Hemodial Int 11:21–31
Hecking M, Kainz A, Hörl WH, Herkner H, Sunder-Plassmann G (2011) Sodium setpoint and sodium gradient: influence on plasma sodium change and weight gain. Am J Nephrol 33:39–48 DOI 10.1159/000322572
Tura A, Sbrignadello S, Mambelli E, Ravazzani P, Santoro A, Pacini G (2013) Sodium concentration measurement during hemodialysis through ion-exchange resin and conductivity measure approach: in vitro experiments. PLoS One 8:e69227 DOI 10.1371/journal.pone.0069227
Yano T, Matsushige H, Suehara K, Nakano Y (2000) Measurement of the concentrations of glucose and lactic acid in peritoneal dialysis solutions using near-infrared spectroscopy. J Biosci Bioeng 90:540–544
Eddy CV, Arnold MA (2001) Near-infrared spectroscopy for measuring urea in hemodialysis fluids. Clin Chem 47:1279–1286
Maruo K, Yamada Y (2015) Near-infrared noninvasive blood glucose prediction without using multivariate analyses: introduction of imaginary spectra due to scattering change in the skin. J Biomed Opt 20:047003 DOI 10.1117/1.JBO.20.4.047003
Alexeeva NV, Arnold MA (2009) Near-infrared microspectroscopic analysis of rat skin tissue heterogeneity in relation to noninvasive glucose sensing. J Diabetes Sci Technol 3:219–232
Yamakoshi Y, Ogawa M, Yamakoshi T, Satoh M, Nogawa M, Tanaka S, Tamura T, Rolfe P, Yamakoshi K (2007) A new non-invasive method for measuring blood glucose using instantaneous differential near infrared spectrophotometry. Conf Proc IEEE Eng Med Biol Soc 2007:2964–2967
Tura A, Maran A, Pacini G (2007) Non-invasive glucose monitoring: assessment of technologies and devices according to quantitative criteria. Diabetes Res Clin Pract 77:16–40
Khalil OS (2004) Non-invasive glucose measurement technologies: an update from 1999 to the dawn of the new millennium. Diabetes Technol Ther 6:660–697
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Sbrignadello, S., Pacini, G., Tura, A. (2016). Near-Infrared Spectroscopy Based on Portable Instrument for the Assessment of Glucose Concentration: In Vitro Experiments. In: Kyriacou, E., Christofides, S., Pattichis, C. (eds) XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016. IFMBE Proceedings, vol 57. Springer, Cham. https://doi.org/10.1007/978-3-319-32703-7_146
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DOI: https://doi.org/10.1007/978-3-319-32703-7_146
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