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Barrier Mechanisms in Neonatal Stroke

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Non-Neuronal Mechanisms of Brain Damage and Repair After Stroke

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

Both clinical and experimental data indicate that the pathophysiology of perinatal brain damage is multifactorial and is in many ways distinct from that of adult stroke. Development of the blood–brain barrier (BBB) begins mid-gestation in rodents and continues during the postnatal period. Therefore, the stage of maturation of individual components of the BBB and other brain barriers may play a central role in age-specific responses of an immature brain to cerebral ischemia and hypoxia, affecting injury subtypes, severity, and evolution. We discuss some of the most recent findings regarding the neurovascular responses of the immature brain to focal arterial stroke and modulation of these processes by inflammatory signaling.

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Sources of Funding

NINDS_NS80015, NINDS_NS44025, NINDS_NS76726, The Leducq Foundation DSRR_P34404.

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Authors and Affiliations

  1. Department of Neurology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA, 94158-0663, USA

    Zinaida S. Vexler Ph.D.

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  1. Zinaida S. Vexler Ph.D.
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Correspondence to Zinaida S. Vexler Ph.D. .

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Editors and Affiliations

  1. Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Jun Chen

  2. Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    John H. Zhang

  3. Department of Anesthesiology, Loma Linda University School of Medicine, Loma Linda, California, USA

    Xiaoming Hu

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Vexler, Z.S. (2016). Barrier Mechanisms in Neonatal Stroke. In: Chen, J., Zhang, J., Hu, X. (eds) Non-Neuronal Mechanisms of Brain Damage and Repair After Stroke. Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-319-32337-4_4

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  • DOI: https://doi.org/10.1007/978-3-319-32337-4_4

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