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Ovarian Sex Cord Tumors

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Ovarian Cancers

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Abstract

Sex cord–stromal tumors (SCSTs) account for approximately 10% of all malignant ovarian neoplasms. The low incidence, the histological heterogeneity, and the variable biologic behavior, makes their optimal management difficult. SCSTs constitute a heterogeneous group of tumors and according to the World Health Organization, they are classified into these categories: pure stromal tumors, pure sex cord tumors (i.e. granulosa cell tumor) and mixed sex cordstromal tumors (Sertoli-Leydig cell tumors).

Histologically, these tumors are considered malignant neoplasms; their natural history, however, is indolent with a very favorable long-term prognosis. Treatment principles have generally based on small series and borrowed from clinical management of epithelial tumors. Adequate knowledge of these neoplasms is imperative to the appropriate diagnosis, choice of surgical treatment and adjuvant therapy.

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  1. Division of Gynecologic Oncology, European Institute of Oncology, Milan, Italy

    Annalisa Garbi, Maria Teresa Achilarre & Nicoletta Colombo

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  1. Annalisa Garbi
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  2. Maria Teresa Achilarre
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  3. Nicoletta Colombo
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Correspondence to Nicoletta Colombo .

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  1. AP-HP, Hôtel-Dieu, Paris, France

    Eric Pujade-Lauraine

  2. Centre Léon Bérard, Université Claude Bernard, Lyon, France

    Isabelle Ray-Coquard

  3. Chirurgie cancérologique, HEGP, Paris, France

    Fabrice Lécuru

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Garbi, A., Achilarre, M.T., Colombo, N. (2017). Ovarian Sex Cord Tumors. In: Pujade-Lauraine, E., Ray-Coquard, I., Lécuru, F. (eds) Ovarian Cancers. Springer, Cham. https://doi.org/10.1007/978-3-319-32110-3_19

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