Abstract
Radiation treatment for skin cancers differs from other types of radiation treatment, because in the case of skin cancers, the skin itself is part of the target and a skin reaction is anticipated and desired. The level of expected reaction can be reasonably estimated in advance by an experienced clinician depending on the technique, dose, and location of treatment.
In general, reactions due to skin cancer irradiation tend to be moderate, because the actual area of targeted skin in the vast majority of cases is usually not large. Long-term complications identified in the literature include alopecia, pigmentation change, telangiectasia, fibrosis/scar, atrophy/contraction, epiphora, and, rarely, soft tissue or cartilage necrosis, bone necrosis, cataracts, dry eye, conjunctival scarring, and eyelid deformity. Rates of severe late complications are generally very low but may be highest for skin cancer treatments on the pinna.
Extent of skin reactions is largely determined by the total dose and fractionation scheme that are chosen, as well as whether dosimetric or physical shielding is used to protect adjacent nontargeted skin. Other factors affecting acute skin toxicity are prior UV damage, prior surgery and/or reconstruction, and the use of systemic agents.
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Yom, S.S., Arron, S. (2016). Skin Cancer. In: Fowble, B., Yom, S., Yuen, F., Arron, S. (eds) Skin Care in Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-31460-0_14
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DOI: https://doi.org/10.1007/978-3-319-31460-0_14
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